NameRetinol dehydrogenase 8
Synonyms
  • 1.1.1.300
  • Photoreceptor outer segment all-trans retinol dehydrogenase
  • PRRDH
  • SDR28C2
  • Short chain dehydrogenase/reductase family 28C member 2
Gene NameRDH8
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004562|Retinol dehydrogenase 8
MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTL
TVAQLDVCSDESVAQCLSCIQGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVR
LVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFI
SLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRDLYLPASRKLFCSVGQNPQDVVQ
AIVNVISSTRPPLRRQTNIRYSPLTTLKTVDSSGSLYVRTTHRLLFRCPRLLNLGLQCLS
CGCLPTRVRPR
Number of residues311
Molecular Weight33755.02
Theoretical pI8.48
GO Classification
Functions
  • retinol dehydrogenase activity
  • NADP-retinol dehydrogenase activity
  • estradiol 17-beta-dehydrogenase activity
Processes
  • phototransduction, visible light
  • estrogen biosynthetic process
  • retinoid metabolic process
  • visual perception
  • steroid biosynthetic process
Components
  • integral component of plasma membrane
  • cytoplasm
General FunctionRetinol dehydrogenase activity
Specific FunctionRetinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity (By similarity).
Pfam Domain Function
Transmembrane Regions86-106 137-157 169-189
GenBank Protein ID7527474
UniProtKB IDQ9NYR8
UniProtKB Entry NameRDH8_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0019270|Retinol dehydrogenase 8 (RDH8)
ATGAATGGTCAGAGTCAGGTGCTGCCCGGCGGAGGTCACGAGTCCAGGGAGGGGATCAAC
ATGGCCGCTGCACCCCGGACTGTGTTGATCTCCGGCTGCTCATCAGGAATTGGTCTGGAA
CTTGCAGTGCAACTGGCCCATGACCCCAAGAAGCGCTACCAGGTCGTGGCCACCATGAGG
GACCTGGGGAAGAAGGAGACACTGGAGGCAGCTGCTGGGGAGGCTCTGGGGCAGACCCTC
ACCGTGGCCCAGCTGGACGTGTGCAGTGATGAGTCGGTGGCCCAGTGTCTCAGCTGTATC
CAGGGAGAAGTGGACGTGCTGGTGAATAATGCTGGAATGGGCCTGGTGGGGCCCCTGGAG
GGGCTCAGCCTTGCTGCCATGCAGAATGTCTTTGACACCAACTTTTTCGGAGCTGTCCGT
CTCGTCAAAGCTGTGCTTCCAGGCATGAAGAGGAGGCGGCAGGGCCACATCGTGGTGATC
AGCAGTGTCATGGGCCTGCAGGGTGTCATCTTCAACGATGTCTATGCAGCTTCCAAGTTC
GCCCTGGAGGGATTCTTCGAAAGCCTCGCTATCCAGCTGCTGCAGTTCAACATCTTCATC
TCCCTGGTGGAGCCAGGCCCCGTGGTCACCGAGTTTGAGGGGAAGCTTCTGGCGCAGGTT
TCTATGGCTGAGTTCCCAGGCACTGACCCTGAGACCCTGCACTACTTCCGGGACCTCTAT
CTCCCAGCCTCCAGGAAGCTGTTTTGCTCCGTGGGACAGAACCCACAGGACGTGGTTCAG
GCCATTGTCAACGTCATCAGCTCGACTCGACCACCCCTGCGCCGACAGACCAACATCCGC
TACTCGCCGCTGACCACGCTCAAAACCGTGGATTCCTCTGGCAGCCTGTATGTGCGAACG
ACCCACCGCCTCCTCTTCCGCTGTCCACGCCTCCTCAACCTTGGCCTTCAATGTCTGTCC
TGCGGCTGCCTCCCAACGCGGGTGCGGCCAAGATGA
GenBank Gene IDAF229845
GeneCard IDNot Available
GenAtlas IDRDH8
HGNC IDHGNC:14423
Chromosome Location19
Locus19p13.2-p13.3
References
  1. Rattner A, Smallwood PM, Nathans J: Identification and characterization of all-trans-retinol dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol. J Biol Chem. 2000 Apr 14;275(15):11034-43. 10753906
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