NameSolute carrier family 2, facilitated glucose transporter member 8
Synonyms
  • Glucose transporter type 8
  • Glucose transporter type X1
  • GLUT-8
  • GLUT8
  • GLUTX1
Gene NameSLC2A8
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013546|Solute carrier family 2, facilitated glucose transporter member 8
MTPEDPEETQPLLGPPGGSAPRGRRVFLAAFAAALGPLSFGFALGYSSPAIPSLQRAAPP
APRLDDAAASWFGAVVTLGAAAGGVLGGWLVDRAGRKLSLLLCSVPFVAGFAVITAAQDV
WMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVVGILLAYLAGWVLE
WRWLAVLGCVPPSLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLWGSEQGWEDPPIGAE
QSFHLALLRQPGIYKPFIIGVSLMAFQQLSGVNAVMFYAETIFEEAKFKDSSLASVVVGV
IQVLFTAVAALIMDRAGRRLLLVLSGVVMVFSTSAFGAYFKLTQGGPGNSSHVAISAPVS
AQPVDASVGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWLM
AFLVTKEFSSLMEVLRPYGAFWLASAFCIFSVLFTLFCVPETKGKTLEQITAHFEGR
Number of residues477
Molecular Weight50818.54
Theoretical pINot Available
GO Classification
Functions
  • glucose binding
  • glucose transmembrane transporter activity
Processes
  • carbohydrate metabolic process
  • transmembrane transport
  • insulin receptor signaling pathway
  • response to hypoxia
  • glucose transport
  • male meiosis I
  • glucose transmembrane transport
Components
  • integral component of plasma membrane
  • lysosomal membrane
  • cytoplasmic vesicle membrane
  • plasma membrane
  • synaptic vesicle
General FunctionGlucose transmembrane transporter activity
Specific FunctionInsulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose (By similarity).
Pfam Domain Function
Transmembrane Regions26-46 71-91 97-117 128-148 157-177 183-203 257-277 293-313 320-340 368-388 405-425 439-459
GenBank Protein IDNot Available
UniProtKB IDQ9NY64
UniProtKB Entry NameGTR8_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0013547|Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8)
ATGACGCCCGAGGACCCAGAGGAAACCCAGCCGCTTCTGGGGCCTCCTGGCGGCAGCGCG
CCCCGCGGCCGCCGCGTCTTCCTCGCCGCCTTCGCCGCTGCCCTGGGCCCACTCAGCTTC
GGCTTCGCGCTCGGCTACAGCTCCCCGGCCATCCCTAGCCTGCAGCGCGCCGCGCCCCCG
GCCCCGCGCCTGGACGACGCCGCCGCCTCCTGGTTCGGGGCTGTCGTGACCCTGGGTGCC
GCGGCGGGGGGAGTGCTGGGCGGCTGGCTGGTGGACCGCGCCGGGCGCAAGCTGAGCCTC
TTGCTGTGCTCCGTGCCCTTCGTGGCCGGCTTTGCCGTCATCACCGCGGCCCAGGACGTG
TGGATGCTGCTGGGGGGCCGCCTCCTCACCGGCCTGGCCTGCGGTGTTGCCTCCCTAGTG
GCCCCGGTCTACATCTCCGAAATCGCCTACCCAGCAGTCCGGGGGTTGCTCGGCTCCTGT
GTGCAGCTAATGGTCGTCGTCGGCATCCTCCTGGCCTACCTGGCAGGCTGGGTGCTGGAG
TGGCGCTGGCTGGCTGTGCTGGGCTGCGTGCCCCCCTCCCTCATGCTGCTTCTCATGTGC
TTCATGCCCGAGACCCCGCGCTTCCTGCTGACTCAGCACAGGCGCCAGGAGGCCATGGCC
GCCCTGCGGTTCCTGTGGGGCTCCGAGCAGGGCTGGGAAGACCCCCCCATCGGGGCTGAG
CAGAGCTTTCACCTGGCCCTGCTGCGGCAGCCCGGCATCTACAAGCCCTTCATCATCGGC
GTCTCCCTGATGGCCTTCCAGCAGCTGTCGGGGGTCAACGCCGTCATGTTCTATGCAGAG
ACCATCTTTGAAGAGGCCAAGTTCAAGGACAGCAGCCTGGCCTCGGTCGTCGTGGGTGTC
ATCCAGGTGCTGTTCACAGCTGTGGCGGCTCTCATCATGGACAGAGCAGGGCGGAGGCTG
CTCCTGGTCTTGTCAGGTGTGGTCATGGTGTTCAGCACGAGTGCCTTCGGCGCCTACTTC
AAGCTGACCCAGGGTGGCCCTGGCAACTCCTCGCACGTGGCCATCTCGGCGCCTGTCTCT
GCACAGCCTGTTGATGCCAGCGTGGGGCTGGCCTGGCTGGCCGTGGGCAGCATGTGCCTC
TTCATCGCCGGAGGTCCTCAGGCCCTATGGAGCCTTCTGGCTTGCCTCCGCTTTCTGCAT
CTTCAGTGTCCTTTTCACTTTGTTCTGTGTCCCTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:13812
Chromosome Location9
LocusNot Available
References
  1. Doege H, Schurmann A, Bahrenberg G, Brauers A, Joost HG: GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity. J Biol Chem. 2000 May 26;275(21):16275-80. 10821868
  2. Ibberson M, Uldry M, Thorens B: GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues. J Biol Chem. 2000 Feb 18;275(7):4607-12. 10671487
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