NameOdorant-binding protein 2a
Synonyms
  • OBPIIa
  • Odorant-binding protein IIa
Gene NameOBP2A
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009858|Odorant-binding protein 2a
MKTLFLGVTLGLAAALSFTLEEEDITGTWYVKAMVVDKDFPEDRRPRKVSPVKVTALGGG
NLEATFTFMREDRCIQKKILMRKTEEPGKFSAYGGRKLIYLQELPGTDDYVFYCKDQRRG
GLRYMGKLVGRNPNTNLEALEEFKKLVQHKGLSEEDIFMPLQTGSCVLEH
Number of residues170
Molecular Weight19318.245
Theoretical pINot Available
GO Classification
Functions
  • odorant binding
Processes
  • transport
  • response to stimulus
  • sensory perception of chemical stimulus
  • sensory perception of smell
Components
  • extracellular region
General FunctionOdorant binding
Specific FunctionProbably binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes and large fatty acids.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ9NY56
UniProtKB Entry NameOBP2A_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0017851|Odorant-binding protein 2a (OBP2A)
ATGAAGACCCTGTTCCTGGGTGTCACGCTCGGCCTGGCCGCTGCCCTGTCCTTCACCCTG
GAGGAGGAGGATATCACAGGGACCTGGTACGTGAAGGCCATGGTGGTCGATAAGGACTTT
CCGGAGGACAGGAGGCCCAGGAAGGTGTCCCCAGTGAAGGTGACAGCCCTGGGCGGTGGG
AACTTGGAAGCCACGTTCACCTTCATGAGGGAGGATCGGTGCATCCAGAAGAAAATCCTG
ATGCGGAAGACGGAGGAGCCTGGCAAATTCAGCGCCTATGGGGGCAGGAAGCTCATATAC
CTGCAGGAGCTGCCCGGGACGGACGACTACGTCTTTTACTGCAAAGACCAGCGCCGTGGG
GGCCTGCGCTACATGGGAAAGCTTGTGGGTAGGAATCCTAATACCAACCTGGAGGCCCTG
GAAGAATTTAAGAAATTGGTGCAGCACAAGGGACTCTCGGAGGAGGACATTTTCATGCCC
CTGCAGACGGGAAGCTGCGTTCTCGAACACTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:23380
Chromosome Location9
LocusNot Available
References
  1. Lacazette E, Gachon AM, Pitiot G: A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: differential expression in the oral and genital spheres. Hum Mol Genet. 2000 Jan 22;9(2):289-301. 10607840
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  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334
  4. Briand L, Eloit C, Nespoulous C, Bezirard V, Huet JC, Henry C, Blon F, Trotier D, Pernollet JC: Evidence of an odorant-binding protein in the human olfactory mucus: location, structural characterization, and odorant-binding properties. Biochemistry. 2002 Jun 11;41(23):7241-52. 12044155