Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC

NameMannosyl-oligosaccharide 1,2-alpha-mannosidase IC
Synonyms
  • 3.2.1.113
  • Alpha-1,2-mannosidase IC
  • HMIC
  • MAN1A3
  • MAN1C
  • Mannosidase alpha class 1C member 1
  • Processing alpha-1,2-mannosidase IC
Gene NameMAN1C1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0020871|Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC
MLMRKVPGFVPASPWGLRLPQKFLFLLFLSGLVTLCFGALFLLPHSSRLKRLFLAPRTQQ
PGLEVVAEIAGHAPAREQEPPPNPAPAAPAPGEDDPSSWASPRRRKGGLRRTRPTGPREE
ATAARGNSIPASRPGDEGVPFRFDFNAFRSRLRHPVLGTRADESQEPQSQVRAQREKIKE
MMQFAWQSYKRYAMGKNELRPLTKDGYEGNMFGGLSGATVIDSLDTLYLMELKEEFQEAK
AWVGESFHLNVSGEASLFEVNIRYIGGLLSAFYLTGEEVFRIKAIRLGEKLLPAFNTPTG
IPKGVVSFKSGNWGWATAGSSSILAEFGSLHLEFLHLTELSGNQVFAEKVRNIRKVLRKI
EKPFGLYPNFLSPVSGNWVQHHVSVGGLGDSFYEYLIKSWLMSGKTDMEAKNMYYEALEA
IETYLLNVSPGGLTYIAEWRGGILDHKMGHLACFSGGMIALGAEDAKEEKRAHYRELAAQ
ITKTCHESYARSDTKLGPEAFWFNSGREAVATQLSESYYILRPEVVESYMYLWRQTHNPI
YREWGWEVVLALEKYCRTEAGFSGIQDVYSSTPNHDNKQQSFFLAETLKYLYLLFSEDDL
LSLEDWVFNTEAHPLPVNHSDSSGRAWGRH
Number of residues630
Molecular Weight70910.025
Theoretical pINot Available
GO Classification
Functions
  • calcium ion binding
  • mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
Processes
  • protein N-linked glycosylation
  • N-glycan processing
  • cellular protein metabolic process
  • post-translational protein modification
  • protein N-linked glycosylation via asparagine
Components
  • integral component of Golgi membrane
  • endoplasmic reticulum
  • extracellular exosome
  • Golgi membrane
General FunctionMannosyl-oligosaccharide 1,2-alpha-mannosidase activity
Specific FunctionInvolved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc.
Pfam Domain Function
Transmembrane Regions23-43
GenBank Protein IDNot Available
UniProtKB IDQ9NR34
UniProtKB Entry NameMA1C1_HUMAN
Cellular LocationGolgi apparatus membrane
Gene sequence
>lcl|BSEQ0020872|Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (MAN1C1)
ATGCTCATGAGGAAAGTGCCCGGCTTCGTCCCGGCCTCCCCGTGGGGGCTGCGGCTGCCG
CAGAAGTTCCTCTTCCTCCTCTTCCTCTCGGGCCTGGTCACCCTGTGCTTCGGGGCCCTC
TTCCTGCTGCCCCACTCCTCTCGCCTCAAGCGCCTCTTCCTGGCCCCCCGGACCCAGCAG
CCTGGTCTGGAAGTGGTGGCTGAAATCGCCGGCCATGCCCCGGCCCGCGAGCAGGAGCCG
CCTCCCAACCCGGCCCCCGCCGCGCCGGCCCCGGGCGAGGATGACCCCAGCAGCTGGGCC
AGTCCCCGCCGCAGGAAAGGGGGGCTGCGGCGCACCCGCCCCACTGGACCCCGCGAGGAG
GCCACGGCGGCCCGGGGCAATAGCATCCCGGCCTCCAGGCCCGGGGACGAGGGCGTCCCT
TTCCGCTTTGACTTCAACGCATTCCGGAGCCGTCTCCGCCACCCGGTCCTGGGAACGAGG
GCCGATGAGAGTCAGGAGCCCCAGAGCCAAGTGCGAGCCCAGCGGGAGAAAATCAAGGAG
ATGATGCAGTTTGCTTGGCAGAGCTATAAGCGTTATGCAATGGGGAAAAACGAACTCCGT
CCACTAACAAAAGATGGCTACGAGGGTAACATGTTCGGAGGCCTCAGCGGGGCAACAGTC
ATTGACTCCCTCGATACCCTCTACCTCATGGAGCTGAAGGAGGAGTTCCAGGAGGCCAAG
GCCTGGGTGGGAGAGAGCTTCCACCTGAACGTGAGCGGAGAAGCATCCTTGTTTGAGGTG
AACATCCGCTACATCGGGGGACTCCTCTCAGCCTTCTACCTGACAGGAGAAGAGGTGTTC
CGAATAAAGGCCATCAGGCTGGGAGAGAAGCTCCTGCCGGCGTTCAACACCCCCACGGGA
ATCCCAAAGGGCGTGGTGAGCTTCAAAAGTGGGAACTGGGGCTGGGCCACAGCCGGCAGC
AGCAGCATCTTGGCGGAGTTTGGATCCCTGCACTTGGAATTCTTACACCTCACTGAACTC
TCTGGCAACCAGGTCTTCGCTGAAAAGGTCAGGAACATCCGCAAGGTCCTCAGGAAGATC
GAAAAGCCCTTTGGCCTCTACCCCAACTTCCTCAGCCCAGTGAGTGGGAACTGGGTGCAA
CACCATGTCTCAGTTGGAGGACTCGGGGACAGTTTTTATGAATATTTGATCAAATCCTGG
TTGATGTCGGGCAAGACAGATATGGAGGCTAAAAATATGTACTACGAAGCCTTGGAGGCG
ATAGAGACCTACTTGCTGAATGTCTCTCCCGGGGGGCTGACCTACATTGCCGAGTGGCGA
GGGGGGATTCTGGACCACAAGATGGGGCACCTGGCCTGTTTCTCCGGGGGCATGATCGCC
CTTGGCGCCGAGGATGCCAAGGAAGAAAAGAGGGCCCACTACCGAGAGCTCGCAGCCCAG
ATCACCAAGACGTGTCACGAGTCATACGCCCGCTCAGACACCAAACTTGGGCCTGAGGCC
TTCTGGTTTAACTCCGGCAGAGAGGCCGTGGCCACCCAGCTGAGCGAGAGCTACTACATC
CTCCGGCCAGAGGTGGTGGAGAGCTACATGTACCTGTGGCGACAGACCCACAACCCCATC
TACAGGGAGTGGGGCTGGGAGGTGGTGCTGGCCTTGGAGAAATACTGTCGGACAGAAGCC
GGTTTCTCTGGGATCCAAGACGTGTACAGTAGCACCCCCAACCACGACAACAAGCAGCAG
AGCTTCTTTCTAGCGGAGACACTAAAGATTTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:19080
Chromosome Location1
LocusNot Available
References
  1. Tremblay LO, Herscovics A: Characterization of a cDNA encoding a novel human Golgi alpha 1, 2-mannosidase (IC) involved in N-glycan biosynthesis. J Biol Chem. 2000 Oct 13;275(41):31655-60. 10915796
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