Platelet glycoprotein VI

NamePlatelet glycoprotein VI
Synonyms
  • Glycoprotein 6
  • GPVI
Gene NameGP6
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009059|Platelet glycoprotein VI
MSPSPTALFCLGLCLGRVPAQSGPLPKPSLQALPSSLVPLEKPVTLRCQGPPGVDLYRLE
KLSSSRYQDQAVLFIPAMKRSLAGRYRCSYQNGSLWSLPSDQLELVATGVFAKPSLSAQP
GPAVSSGGDVTLQCQTRYGFDQFALYKEGDPAPYKNPERWYRASFPIITVTAAHSGTYRC
YSFSSRDPYLWSAPSDPLELVVTGTSVTPSRLPTEPPSPVAEFSEATAELTVSFTNEVFT
TETSRSITASPKESDSPAGPARQYYTKGNLVRICLGAVILIILAGFLAEDWHSRRKRLRH
RGRAVQRPLPPLPPLPLTRKSNGGQDGGRQDVHSRGLCS
Number of residues339
Molecular Weight36865.58
Theoretical pINot Available
GO Classification
Functions
  • transmembrane signaling receptor activity
  • collagen binding
  • receptor activity
Processes
  • platelet activation
  • leukocyte migration
  • enzyme linked receptor protein signaling pathway
  • blood coagulation
Components
  • extracellular exosome
  • integral component of plasma membrane
  • tetraspanin-enriched microdomain
  • plasma membrane
  • cell surface
General FunctionTransmembrane signaling receptor activity
Specific FunctionCollagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.
Pfam Domain Function
Transmembrane Regions268-288
GenBank Protein IDNot Available
UniProtKB IDQ9HCN6
UniProtKB Entry NameGPVI_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0013590|Platelet glycoprotein VI (GP6)
ATGTCTCCATCCCCGACCGCCCTCTTCTGTCTTGGGCTGTGTCTGGGGCGTGTGCCAGCG
CAGAGTGGACCGCTCCCCAAGCCCTCCCTCCAGGCTCTGCCCAGCTCCCTGGTGCCCCTG
GAGAAGCCAGTGACCCTCCGGTGCCAGGGACCTCCGGGCGTGGACCTGTACCGCCTGGAG
AAGCTGAGTTCCAGCAGGTACCAGGATCAGGCAGTCCTCTTCATCCCGGCCATGAAGAGA
AGTCTGGCTGGACGCTACCGCTGCTCCTACCAGAACGGAAGCCTCTGGTCCCTGCCCAGC
GACCAGCTGGAGCTCGTTGCCACGGGAGTTTTTGCCAAACCCTCGCTCTCAGCCCAGCCC
GGCCCGGCGGTGTCGTCAGGAGGGGACGTAACCCTACAGTGTCAGACTCGGTATGGCTTT
GACCAATTTGCTCTGTACAAGGAAGGGGACCCTGCGCCCTACAAGAATCCCGAGAGATGG
TACAGGGCTAGTTTTCCCATCATCACGGTGACCGCCGCCCACAGCGGAACCTACCGATGC
TACAGCTTCTCCAGCAGGGACCCATACCTGTGGTCAGCCCCCAGCGACCCCCTGGAGCTT
GTGGTCACAGGAACCTCTGTGACCCCCAGCCGGTTACCAACAGAACCACCTTCCCCGGTA
GCAGAATTCTCAGAAGCCACCGCTGAACTGACCGTCTCATTCACAAACGAAGTCTTCACA
ACTGAGACTTCTAGGAGTATCACCGCCAGTCCAAAGGAGTCAGACTCTCCAGCTGGTGAG
TCCTGCCCGCCAGTACTACACCAAGGGCAACCTGGTCCGGATATGCCTCGGGGCTGTGAT
CCTAATAATCCTGGCGGGGTTTCTGGCAGAGGACTGGCACAGCCGGAGGAAGCGCCTGCG
GCACAGGGGCAGGGCTGTGCAGAGGCCGCTTCCGCCCCTCCCGCCCCTCCCGCTGACCCG
GAAATCAAACGGGGGTCAGGATGGAGGCCGACAGGATGTTCACAGCCGCGGGTTATGTTC
ATGACCGCTGAACCCCAGGCACGGTCGTATCCAAGGGAGGGATCATGGCATGGGAGGCGA
CTCAAAGACTGGCGTGTGTGGAGCGTGGAAGCAGGAGGGCAGAGGCTACAGCTGTGGAAA
CGAGGCCATGCTGCCTCCTCCTGGTGTTCCATCAGGGAGCCGTTCGGCCAGTGTCTGTCT
GTCTGTCTGCCTCTCTGTCTGAGGGCACCCTCCATTTGGGATGGAAGGAATCTGTGGAGA
CCCCATCCTCCTCCCTGCACACTGTGGATGACATGGTACCCTGGCTGGACCACATACTGG
CCTCTTTCTTCAACCTCTCTAATATGGGCTCCAGACGGATCTCTAAGGTTCCCAGCTCTC
AGGGTTGACTCTGTTCCATCCTCTGTGCAAAATCCTCCCGTGCTTCCCTTTGGCCCTCTG
TGCTCTTGTCTGGTTTTCCCCAGAAACTCTCACCCTCACTCCATCTCCCACTGCGGTCTA
ACAAATCTCCTTTCGTCTCTCAGAACGGGTCTTGCAGGCAGTTTGGGTATGTCATTCATT
TTCCTTAGTGTAAAACTAGCACGTTGCCCGCTTCCCTTCACATTAGAAAACAAGATCAGC
CTGTGCAACATGGTGAAACCTCATCTCTACCAACAAAACAAAAAAACACAAAAATTAGCC
AGGTGTGGTGGTGCATCCCTATACTCCCAGCAACTCAGGGGGCTGAGGTGGGAGAATGGC
TTGAGCCTGGGAGGCAGAGGTTGCAGTGAGCTGAGATCACACCACTGCACTCTAGCTCGG
GTGACGAAGCCTGACTTTGTCTCAAAAAATACAGGGATGAATATGTCAATTACCCTGATT
TGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:14388
Chromosome Location19
LocusNot Available
References
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  2. Jandrot-Perrus M, Busfield S, Lagrue AH, Xiong X, Debili N, Chickering T, Le Couedic JP, Goodearl A, Dussault B, Fraser C, Vainchenker W, Villeval JL: Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily. Blood. 2000 Sep 1;96(5):1798-807. 10961879
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  5. Tsuji M, Ezumi Y, Arai M, Takayama H: A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets. J Biol Chem. 1997 Sep 19;272(38):23528-31. 9295288
  6. Kunicki TJ, Cheli Y, Moroi M, Furihata K: The influence of N-linked glycosylation on the function of platelet glycoprotein VI. Blood. 2005 Oct 15;106(8):2744-9. Epub 2005 Jul 12. 16014566
  7. O'Connor MN, Smethurst PA, Farndale RW, Ouwehand WH: Gain- and loss-of-function mutants confirm the importance of apical residues to the primary interaction of human glycoprotein VI with collagen. J Thromb Haemost. 2006 Apr;4(4):869-73. Epub 2005 Dec 23. 16405521
  8. Horii K, Kahn ML, Herr AB: Structural basis for platelet collagen responses by the immune-type receptor glycoprotein VI. Blood. 2006 Aug 1;108(3):936-42. 16861347
  9. Dumont B, Lasne D, Rothschild C, Bouabdelli M, Ollivier V, Oudin C, Ajzenberg N, Grandchamp B, Jandrot-Perrus M: Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations. Blood. 2009 Aug 27;114(9):1900-3. doi: 10.1182/blood-2009-03-213504. Epub 2009 Jun 23. 19549989
  10. Hermans C, Wittevrongel C, Thys C, Smethurst PA, Van Geet C, Freson K: A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorder. J Thromb Haemost. 2009 Aug;7(8):1356-63. doi: 10.1111/j.1538-7836.2009.03520.x. Epub 2009 Jun 22. 19552682