T3DB: Adhesion G protein-coupled receptor L3

Name	Adhesion G protein-coupled receptor L3
Synonyms	Calcium-independent alpha-latrotoxin receptor 3 CIRL-3 KIAA0768 Latrophilin-3 LEC3 Lectomedin-3 LPHN3
Gene Name	ADGRL3
Organism	Human
Amino acid sequence	>lcl\|BSEQ0009044\|Adhesion G protein-coupled receptor L3 MWPSQLLIFMMLLAPIIHAFSRAPIPMAVVRRELSCESYPIELRCPGTDVIMIESANYGR TDDKICDSDPAQMENIRCYLPDAYKIMSQRCNNRTQCAVVAGPDVFPDPCPGTYKYLEVQ YECVPYKVEQKVFLCPGLLKGVYQSEHLFESDHQSGAWCKDPLQASDKIYYMPWTPYRTD TLTEYSSKDDFIAGRPTTTYKLPHRVDGTGFVVYDGALFFNKERTRNIVKFDLRTRIKSG EAIIANANYHDTSPYRWGGKSDIDLAVDENGLWVIYATEQNNGKIVISQLNPYTLRIEGT WDTAYDKRSASNAFMICGILYVVKSVYEDDDNEATGNKIDYIYNTDQSKDSLVDVPFPNS YQYIAAVDYNPRDNLLYVWNNYHVVKYSLDFGPLDSRSGQAHHGQVSYISPPIHLDSELE RPSVKDISTTGPLGMGSTTTSTTLRTTTLSPGRSTTPSVSGRRNRSTSTPSPAVEVLDDM TTHLPSASSQIPALEESCEAVEAREIMWFKTRQGQIAKQPCPAGTIGVSTYLCLAPDGIW DPQGPDLSNCSSPWVNHITQKLKSGETAANIARELAEQTRNHLNAGDITYSVRAMDQLVG LLDVQLRNLTPGGKDSAARSLNKAMVETVNNLLQPQALNAWRDLTTSDQLRAATMLLHTV EESAFVLADNLLKTDIVRENTDNIKLEVARLSTEGNLEDLKFPENMGHGSTIQLSANTLK QNGRNGEIRVAFVLYNNLGPYLSTENASMKLGTEALSTNHSVIVNSPVITAAINKEFSNK VYLADPVVFTVKHIKQSEENFNPNCSFWSYSKRTMTGYWSTQGCRLLTTNKTHTTCSCNH LTNFAVLMAHVEVKHSDAVHDLLLDVITWVGILLSLVCLLICIFTFCFFRGLQSDRNTIH KNLCISLFVAELLFLIGINRTDQPIACAVFAALLHFFFLAAFTWMFLEGVQLYIMLVEVF ESEHSRRKYFYLVGYGMPALIVAVSAAVDYRSYGTDKVCWLRLDTYFIWSFIGPATLIIM LNVIFLGIALYKMFHHTAILKPESGCLDNIKSWVIGAIALLCLLGLTWAFGLMYINESTV IMAYLFTIFNSLQGMFIFIFHCVLQKKVRKEYGKCLRTHCCSGKSTESSIGSGKTSGSRT PGRYSTGSQSRIRRMWNDTVRKQSESSFITGDINSSASLNREGLLNNARDTSVMDTLPLN GNHGNSYSIASGEYLSNCVQIIDRGYNHNETALEKKILKELTSNYIPSYLNNHERSSEQN RNLMNKLVNNLGSGREDDAIVLDDATSFNHEESLGLELIHEESDAPLLPPRVYSTENHQP HHYTRRRIPQDHSESFFPLLTNEHTEDLQSPHRDSLYTSMPTLAGVAATESVTTSTQTEP PPAKCGDAEDVYYKSMPNLGSRNHVHQLHTYYQLGRGSSDGFIVPPNKDGTPPEGSSKGP AHLVTSL
Number of residues	1447
Molecular Weight	161810.84
Theoretical pI	Not Available
GO Classification	Functions G-protein coupled receptor activity calcium ion binding carbohydrate binding Processes G-protein coupled receptor signaling pathway cell surface receptor signaling pathway synapse assembly neuron migration positive regulation of synapse assembly cell-cell adhesion Components cell-cell junction axon integral component of membrane integral component of plasma membrane
General Function	G-protein coupled receptor activity
Specific Function	Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells (PubMed:26235030). Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex.
Pfam Domain Function	7tm_2 (PF00002 ) HRM (PF02793 ) GPS (PF01825 ) GAIN (PF16489 ) Gal_Lectin (PF02140 ) Latrophilin (PF02354 ) OLF (PF02191 )
Transmembrane Regions	867-889 902-919 934-956 969-988 1008-1030 1050-1072 1082-1104
GenBank Protein ID	Not Available
UniProtKB ID	Q9HAR2
UniProtKB Entry Name	AGRL3_HUMAN
Cellular Location	Cell membrane
Gene sequence	>lcl\|BSEQ0017674\|Adhesion G protein-coupled receptor L3 (ADGRL3) ATGTGGCCATCGCAGCTACTAATTTTCATGATGCTCTTAGCTCCAATAATTCATGCTTTC AGCCGTGCCCCAATTCCAATGGCTGTGGTCCGCAGAGAGCTATCCTGTGAGAGCTATCCT ATAGAGCTTCGCTGTCCAGGAACAGACGTCATCATGATAGAAAGTGCCAACTATGGCAGG ACTGATGACAAAATTTGTGACTCTGACCCTGCTCAGATGGAGAATATCCGATGTTATCTG CCAGATGCCTATAAGATTATGTCTCAAAGATGCAATAACAGAACCCAGTGTGCAGTGGTG GCAGGTCCTGATGTTTTTCCAGACCCGTGTCCAGGAACCTATAAATACCTTGAAGTGCAG TATGAATGTGTCCCTTACAAAGTGGAACAAAAAGTTTTTCTTTGTCCTGGACTACTAAAA GGAGTATACCAGAGTGAACATTTGTTTGAGTCCGACCACCAATCTGGGGCGTGGTGCAAA GACCCTCTGCAGGCATCTGACAAGATTTATTATATGCCCTGGACTCCCTACAGAACTGAT ACCCTGACTGAGTATTCATCCAAGGATGACTTCATTGCTGGAAGACCAACTACAACCTAC AAGCTCCCTCACAGGGTGGATGGCACAGGATTTGTAGTGTATGATGGAGCTTTGTTCTTC AACAAAGAGCGCACCAGGAACATAGTAAAGTTTGATTTGCGGACTAGGATAAAGAGTGGA GAGGCTATCATAGCAAATGCCAATTACCATGATACCTCCCCTTACCGATGGGGAGGCAAA TCTGACATAGACCTGGCAGTAGATGAGAATGGGCTATGGGTAATCTATGCAACAGAACAA AACAATGGTAAAATTGTCATTAGTCAATTGAACCCTTACACCCTACGGATCGAAGGAACA TGGGATACTGCATATGATAAAAGGTCAGCTTCCAATGCCTTTATGATTTGTGGAATTCTG TATGTGGTCAAATCTGTATATGAGGATGATGACAATGAGGCTACTGGAAATAAGATTGAC TACATTTACAACACTGACCAAAGCAAGGATAGTTTGGTGGATGTACCCTTTCCTAATTCA TACCAGTACATTGCAGCTGTGGATTACAACCCCAGGGACAACCTACTTTATGTATGGAAT AACTATCACGTCGTGAAATATTCTTTGGATTTTGGACCTCTGGATAGTAGATCAGGGCAG GCACATCATGGACAAGTTTCATACATTTCTCCGCCAATTCACCTTGACTCTGAGCTAGAA AGACCCTCTGTTAAAGATATCTCTACCACAGGACCTCTTGGCATGGGAAGCACTACCACC AGTACCACCCTTCGGACCACAACTTTGAGCCCAGGAAGGAGTACCACCCCGTCAGTGTCA GGAAGAAGAAACCGGAGTACTAGTACCCCATCTCCAGCTGTCGAGGTACTTGATGACATG ACCACACACCTTCCATCAGCATCGTCCCAAATCCCAGCTCTCGAAGAGAGCTGTGAGGCT GTGGAAGCCCGAGAAATCATGTGGTTTAAGACTCGTCAAGGACAGATAGCAAAGCAGCCA TGCCCTGCAGGAACTATAGGTGTATCAACTTATCTATGCCTTGCTCCTGATGGAATTTGG GATCCCCAAGGTCCAGATCTCAGCAACTGTTCTTCTCCTTGGGTCAATCATATAACACAG AAGTTGAAATCTGGTGAAACAGCTGCCAACATTGCTAGAGAGCTGGCTGAACAGACAAGA AATCACTTGAATGCTGGGGACATCACCTACTCTGTCCGGGCCATGGACCAGCTGGTAGGC CTCCTAGATGTACAGCTTCGGAACTTGACCCCAGGTGGAAAAGATAGTGCTGCCCGGAGT TTGAACAAGCTTCAGAAAAGAGAGCGCTCTTGCAGAGCCTATGTCCAGGCAATGGTCGAG ACAGTTAACAACCTCCTTCAGCCACAAGCTTTGAATGCATGGAGAGACCTGACTACGAGT GATCAGCTGCGTGCGGCCACCATGTTGCTTCATACTGTGGAGGAAAGTGCTTTTGTGCTG GCTGATAACCTTTTGAAGACTGACATTGTCAGGGAGAATACAGACAATATTAAATTGGAA GTTGCAAGACTGAGCACAGAAGGAAACTTAGAAGACCTAAAATTTCCAGAAAACATGGGC CATGGAAGCACTATCCAGCTGTCTGCAAATACCTTAAAGCAAAATGGCCGAAATGGAGAG ATCAGAGTGGCCTTTGTCCTGTATAACAACTTGGGTCCTTATTTATCCACGGAGAATGCC AGTATGAAGTTGGGAACGGAAGCTTTGTCCACAAATCATTCTGTTATTGTCAATTCCCCT GTTATTACGGCAGCAATAAACAAAGAGTTCAGTAACAAGGTTTATTTGGCTGATCCTGTG GTATTTACTGTTAAACATATCAAGCAGTCAGAGGAAAATTTCAACCCTAACTGTTCATTT TGGAGCTACTCCAAGCGTACAATGACAGGTTATTGGTCAACACAAGGCTGTCGGCTCCTG ACAACAAATAAGACACATACTACATGCTCTTGTAACCACCTAACAAATTTTGCAGTACTG ATGGCACATGTGGAAGTTAAGCACAGTGATGCGGTCCATGACCTCCTTCTGGATGTGATC ACGTGGGTTGGAATTTTGCTGTCCCTTGTTTGTCTCCTGATTTGCATCTTCACATTTTGC TTTTTCCGGGGGCTCCAGAGTGACCGTAACACCATCCACAAGAACCTCTGCATCAGTCTC TTTGTAGCAGAGCTGCTCTTCCTGATTGGGATCAACCGAACTGACCAACCAATTGCCTGT GCTGTTTTCGCTGCCCTGTTACATTTCTTCTTCTTGGCTGCCTTCACCTGGATGTTCCTG GAGGGGGTGCAGCTTTATATCATGCTGGTGGAGGTTTTTGAGAGTGAACATTCACGTAGG AAATACTTTTATCTGGTCGGCTATGGGATGCCTGCACTCATTGTGGCTGTGTCAGCTGCA GTAGACTACAGGAGTTATGGAACAGATAAAGTATGTTGGCTCCGACTTGACACCTACTTC ATTTGGAGTTTTATAGGACCAGCAACTTTGATAATTATGCTTAATGTAATCTTCCTTGGG ATTGCTTTATATAAAATGTTTCATCATACTGCTATACTGAAACCTGAATCAGGCTGTCTT GATAACATCAACTATGAGGATAACAGACCCTTCATCAAGTCATGGGTTATAGGTGCAATA GCTCTTCTCTGCCTATTAGGATTGACCTGGGCCTTTGGACTCATGTATATTAATGAAAGC ACAGTCATCATGGCCTATCTCTTCACCATTTTCAATTCTCTACAGGGAATGTTTATATTT ATTTTCCATTGTGTCCTACAGAAGAAGGTACGAAAAGAGTATGGGAAATGCCTGCGAACA CATTGCTGTAGTGGCAAAAGTACAGAGAGTTCCATTGGTTCAGGGAAAACATCTGGTTCT CGAACTCCTGGACGCTACTCCACAGGCTCACAGAGCCGAATCCGTAGAATGTGGAATGAC ACGGTTCGAAAGCAGTCAGAGTCTTCCTTTATTACTGGAGACATAAACAGTTCAGCGTCA CTCAACAGAGAGGGGCTTCTGAACAATGCCAGGGATACAAGTGTCATGGATACTCTACCA CTGAATGGTAACCATGGCAATAGTTACAGCATTGCCAGCGGCGAATACCTGAGCAACTGT GTGCAAATCATAGACCGTGGCTATAACCATAACGAGACCGCCCTAGAGAAAAAGATTCTG AAGGAACTCACTTCCAACTATATCCCTTCTTACCTGAACAACCATGAGCGCTCCAGTGAA CAGAACAGGAATCTGATGAACAAGCTGGTGAATAACCTTGGCAGTGGAAGGGAAGATGAT GCCATTGTCCTGGATGATGCCACCTCGTTTAACCACGAGGAGAGTTTGGGCCTGGAACTC ATTCATGAGGAATCTGATGCTCCTTTGCTGCCCCCAAGAGTATACTCCACCGAGAACCAC CAGCCACACCATTATACCAGAAGGCGGATCCCCCAAGACCACAGTGAGAGCTTTTTCCCT TTGCTAACCAACGAGCACACAGAAGATCTCCAGTCACCCCATAGAGACTCTCTCTATACC AGCATGCCGACACTGGCTGGTGTGGCCGCCACAGAGAGTGTTACCACCAGCACCCAGACC GAACCCCCACCGGCCAAATGTGGTGATGCCGAAGATGTTTACTACAAAAGCATGCCAAAC CTAGGCTCCAGAAACCACGTCCATCAGCTGCATACTTACTACCAGCTAGGTCGCGGCAGC AGTGATGGATTTATAGTTCCTCCAAACAAAGATGGGACCCCTCCCGAGGGAAGTTCAAAA GGACCGGCTCATTTGGTCACTAGTCTATAG
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:20974
Chromosome Location	4
Locus	Not Available
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