NameAdhesion G protein-coupled receptor L3
Synonyms
  • Calcium-independent alpha-latrotoxin receptor 3
  • CIRL-3
  • KIAA0768
  • Latrophilin-3
  • LEC3
  • Lectomedin-3
  • LPHN3
Gene NameADGRL3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009044|Adhesion G protein-coupled receptor L3
MWPSQLLIFMMLLAPIIHAFSRAPIPMAVVRRELSCESYPIELRCPGTDVIMIESANYGR
TDDKICDSDPAQMENIRCYLPDAYKIMSQRCNNRTQCAVVAGPDVFPDPCPGTYKYLEVQ
YECVPYKVEQKVFLCPGLLKGVYQSEHLFESDHQSGAWCKDPLQASDKIYYMPWTPYRTD
TLTEYSSKDDFIAGRPTTTYKLPHRVDGTGFVVYDGALFFNKERTRNIVKFDLRTRIKSG
EAIIANANYHDTSPYRWGGKSDIDLAVDENGLWVIYATEQNNGKIVISQLNPYTLRIEGT
WDTAYDKRSASNAFMICGILYVVKSVYEDDDNEATGNKIDYIYNTDQSKDSLVDVPFPNS
YQYIAAVDYNPRDNLLYVWNNYHVVKYSLDFGPLDSRSGQAHHGQVSYISPPIHLDSELE
RPSVKDISTTGPLGMGSTTTSTTLRTTTLSPGRSTTPSVSGRRNRSTSTPSPAVEVLDDM
TTHLPSASSQIPALEESCEAVEAREIMWFKTRQGQIAKQPCPAGTIGVSTYLCLAPDGIW
DPQGPDLSNCSSPWVNHITQKLKSGETAANIARELAEQTRNHLNAGDITYSVRAMDQLVG
LLDVQLRNLTPGGKDSAARSLNKAMVETVNNLLQPQALNAWRDLTTSDQLRAATMLLHTV
EESAFVLADNLLKTDIVRENTDNIKLEVARLSTEGNLEDLKFPENMGHGSTIQLSANTLK
QNGRNGEIRVAFVLYNNLGPYLSTENASMKLGTEALSTNHSVIVNSPVITAAINKEFSNK
VYLADPVVFTVKHIKQSEENFNPNCSFWSYSKRTMTGYWSTQGCRLLTTNKTHTTCSCNH
LTNFAVLMAHVEVKHSDAVHDLLLDVITWVGILLSLVCLLICIFTFCFFRGLQSDRNTIH
KNLCISLFVAELLFLIGINRTDQPIACAVFAALLHFFFLAAFTWMFLEGVQLYIMLVEVF
ESEHSRRKYFYLVGYGMPALIVAVSAAVDYRSYGTDKVCWLRLDTYFIWSFIGPATLIIM
LNVIFLGIALYKMFHHTAILKPESGCLDNIKSWVIGAIALLCLLGLTWAFGLMYINESTV
IMAYLFTIFNSLQGMFIFIFHCVLQKKVRKEYGKCLRTHCCSGKSTESSIGSGKTSGSRT
PGRYSTGSQSRIRRMWNDTVRKQSESSFITGDINSSASLNREGLLNNARDTSVMDTLPLN
GNHGNSYSIASGEYLSNCVQIIDRGYNHNETALEKKILKELTSNYIPSYLNNHERSSEQN
RNLMNKLVNNLGSGREDDAIVLDDATSFNHEESLGLELIHEESDAPLLPPRVYSTENHQP
HHYTRRRIPQDHSESFFPLLTNEHTEDLQSPHRDSLYTSMPTLAGVAATESVTTSTQTEP
PPAKCGDAEDVYYKSMPNLGSRNHVHQLHTYYQLGRGSSDGFIVPPNKDGTPPEGSSKGP
AHLVTSL
Number of residues1447
Molecular Weight161810.84
Theoretical pINot Available
GO Classification
Functions
  • G-protein coupled receptor activity
  • calcium ion binding
  • carbohydrate binding
Processes
  • G-protein coupled receptor signaling pathway
  • cell surface receptor signaling pathway
  • synapse assembly
  • neuron migration
  • positive regulation of synapse assembly
  • cell-cell adhesion
Components
  • cell-cell junction
  • axon
  • integral component of membrane
  • integral component of plasma membrane
General FunctionG-protein coupled receptor activity
Specific FunctionPlays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells (PubMed:26235030). Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex.
Pfam Domain Function
Transmembrane Regions867-889 902-919 934-956 969-988 1008-1030 1050-1072 1082-1104
GenBank Protein IDNot Available
UniProtKB IDQ9HAR2
UniProtKB Entry NameAGRL3_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0017674|Adhesion G protein-coupled receptor L3 (ADGRL3)
ATGTGGCCATCGCAGCTACTAATTTTCATGATGCTCTTAGCTCCAATAATTCATGCTTTC
AGCCGTGCCCCAATTCCAATGGCTGTGGTCCGCAGAGAGCTATCCTGTGAGAGCTATCCT
ATAGAGCTTCGCTGTCCAGGAACAGACGTCATCATGATAGAAAGTGCCAACTATGGCAGG
ACTGATGACAAAATTTGTGACTCTGACCCTGCTCAGATGGAGAATATCCGATGTTATCTG
CCAGATGCCTATAAGATTATGTCTCAAAGATGCAATAACAGAACCCAGTGTGCAGTGGTG
GCAGGTCCTGATGTTTTTCCAGACCCGTGTCCAGGAACCTATAAATACCTTGAAGTGCAG
TATGAATGTGTCCCTTACAAAGTGGAACAAAAAGTTTTTCTTTGTCCTGGACTACTAAAA
GGAGTATACCAGAGTGAACATTTGTTTGAGTCCGACCACCAATCTGGGGCGTGGTGCAAA
GACCCTCTGCAGGCATCTGACAAGATTTATTATATGCCCTGGACTCCCTACAGAACTGAT
ACCCTGACTGAGTATTCATCCAAGGATGACTTCATTGCTGGAAGACCAACTACAACCTAC
AAGCTCCCTCACAGGGTGGATGGCACAGGATTTGTAGTGTATGATGGAGCTTTGTTCTTC
AACAAAGAGCGCACCAGGAACATAGTAAAGTTTGATTTGCGGACTAGGATAAAGAGTGGA
GAGGCTATCATAGCAAATGCCAATTACCATGATACCTCCCCTTACCGATGGGGAGGCAAA
TCTGACATAGACCTGGCAGTAGATGAGAATGGGCTATGGGTAATCTATGCAACAGAACAA
AACAATGGTAAAATTGTCATTAGTCAATTGAACCCTTACACCCTACGGATCGAAGGAACA
TGGGATACTGCATATGATAAAAGGTCAGCTTCCAATGCCTTTATGATTTGTGGAATTCTG
TATGTGGTCAAATCTGTATATGAGGATGATGACAATGAGGCTACTGGAAATAAGATTGAC
TACATTTACAACACTGACCAAAGCAAGGATAGTTTGGTGGATGTACCCTTTCCTAATTCA
TACCAGTACATTGCAGCTGTGGATTACAACCCCAGGGACAACCTACTTTATGTATGGAAT
AACTATCACGTCGTGAAATATTCTTTGGATTTTGGACCTCTGGATAGTAGATCAGGGCAG
GCACATCATGGACAAGTTTCATACATTTCTCCGCCAATTCACCTTGACTCTGAGCTAGAA
AGACCCTCTGTTAAAGATATCTCTACCACAGGACCTCTTGGCATGGGAAGCACTACCACC
AGTACCACCCTTCGGACCACAACTTTGAGCCCAGGAAGGAGTACCACCCCGTCAGTGTCA
GGAAGAAGAAACCGGAGTACTAGTACCCCATCTCCAGCTGTCGAGGTACTTGATGACATG
ACCACACACCTTCCATCAGCATCGTCCCAAATCCCAGCTCTCGAAGAGAGCTGTGAGGCT
GTGGAAGCCCGAGAAATCATGTGGTTTAAGACTCGTCAAGGACAGATAGCAAAGCAGCCA
TGCCCTGCAGGAACTATAGGTGTATCAACTTATCTATGCCTTGCTCCTGATGGAATTTGG
GATCCCCAAGGTCCAGATCTCAGCAACTGTTCTTCTCCTTGGGTCAATCATATAACACAG
AAGTTGAAATCTGGTGAAACAGCTGCCAACATTGCTAGAGAGCTGGCTGAACAGACAAGA
AATCACTTGAATGCTGGGGACATCACCTACTCTGTCCGGGCCATGGACCAGCTGGTAGGC
CTCCTAGATGTACAGCTTCGGAACTTGACCCCAGGTGGAAAAGATAGTGCTGCCCGGAGT
TTGAACAAGCTTCAGAAAAGAGAGCGCTCTTGCAGAGCCTATGTCCAGGCAATGGTCGAG
ACAGTTAACAACCTCCTTCAGCCACAAGCTTTGAATGCATGGAGAGACCTGACTACGAGT
GATCAGCTGCGTGCGGCCACCATGTTGCTTCATACTGTGGAGGAAAGTGCTTTTGTGCTG
GCTGATAACCTTTTGAAGACTGACATTGTCAGGGAGAATACAGACAATATTAAATTGGAA
GTTGCAAGACTGAGCACAGAAGGAAACTTAGAAGACCTAAAATTTCCAGAAAACATGGGC
CATGGAAGCACTATCCAGCTGTCTGCAAATACCTTAAAGCAAAATGGCCGAAATGGAGAG
ATCAGAGTGGCCTTTGTCCTGTATAACAACTTGGGTCCTTATTTATCCACGGAGAATGCC
AGTATGAAGTTGGGAACGGAAGCTTTGTCCACAAATCATTCTGTTATTGTCAATTCCCCT
GTTATTACGGCAGCAATAAACAAAGAGTTCAGTAACAAGGTTTATTTGGCTGATCCTGTG
GTATTTACTGTTAAACATATCAAGCAGTCAGAGGAAAATTTCAACCCTAACTGTTCATTT
TGGAGCTACTCCAAGCGTACAATGACAGGTTATTGGTCAACACAAGGCTGTCGGCTCCTG
ACAACAAATAAGACACATACTACATGCTCTTGTAACCACCTAACAAATTTTGCAGTACTG
ATGGCACATGTGGAAGTTAAGCACAGTGATGCGGTCCATGACCTCCTTCTGGATGTGATC
ACGTGGGTTGGAATTTTGCTGTCCCTTGTTTGTCTCCTGATTTGCATCTTCACATTTTGC
TTTTTCCGGGGGCTCCAGAGTGACCGTAACACCATCCACAAGAACCTCTGCATCAGTCTC
TTTGTAGCAGAGCTGCTCTTCCTGATTGGGATCAACCGAACTGACCAACCAATTGCCTGT
GCTGTTTTCGCTGCCCTGTTACATTTCTTCTTCTTGGCTGCCTTCACCTGGATGTTCCTG
GAGGGGGTGCAGCTTTATATCATGCTGGTGGAGGTTTTTGAGAGTGAACATTCACGTAGG
AAATACTTTTATCTGGTCGGCTATGGGATGCCTGCACTCATTGTGGCTGTGTCAGCTGCA
GTAGACTACAGGAGTTATGGAACAGATAAAGTATGTTGGCTCCGACTTGACACCTACTTC
ATTTGGAGTTTTATAGGACCAGCAACTTTGATAATTATGCTTAATGTAATCTTCCTTGGG
ATTGCTTTATATAAAATGTTTCATCATACTGCTATACTGAAACCTGAATCAGGCTGTCTT
GATAACATCAACTATGAGGATAACAGACCCTTCATCAAGTCATGGGTTATAGGTGCAATA
GCTCTTCTCTGCCTATTAGGATTGACCTGGGCCTTTGGACTCATGTATATTAATGAAAGC
ACAGTCATCATGGCCTATCTCTTCACCATTTTCAATTCTCTACAGGGAATGTTTATATTT
ATTTTCCATTGTGTCCTACAGAAGAAGGTACGAAAAGAGTATGGGAAATGCCTGCGAACA
CATTGCTGTAGTGGCAAAAGTACAGAGAGTTCCATTGGTTCAGGGAAAACATCTGGTTCT
CGAACTCCTGGACGCTACTCCACAGGCTCACAGAGCCGAATCCGTAGAATGTGGAATGAC
ACGGTTCGAAAGCAGTCAGAGTCTTCCTTTATTACTGGAGACATAAACAGTTCAGCGTCA
CTCAACAGAGAGGGGCTTCTGAACAATGCCAGGGATACAAGTGTCATGGATACTCTACCA
CTGAATGGTAACCATGGCAATAGTTACAGCATTGCCAGCGGCGAATACCTGAGCAACTGT
GTGCAAATCATAGACCGTGGCTATAACCATAACGAGACCGCCCTAGAGAAAAAGATTCTG
AAGGAACTCACTTCCAACTATATCCCTTCTTACCTGAACAACCATGAGCGCTCCAGTGAA
CAGAACAGGAATCTGATGAACAAGCTGGTGAATAACCTTGGCAGTGGAAGGGAAGATGAT
GCCATTGTCCTGGATGATGCCACCTCGTTTAACCACGAGGAGAGTTTGGGCCTGGAACTC
ATTCATGAGGAATCTGATGCTCCTTTGCTGCCCCCAAGAGTATACTCCACCGAGAACCAC
CAGCCACACCATTATACCAGAAGGCGGATCCCCCAAGACCACAGTGAGAGCTTTTTCCCT
TTGCTAACCAACGAGCACACAGAAGATCTCCAGTCACCCCATAGAGACTCTCTCTATACC
AGCATGCCGACACTGGCTGGTGTGGCCGCCACAGAGAGTGTTACCACCAGCACCCAGACC
GAACCCCCACCGGCCAAATGTGGTGATGCCGAAGATGTTTACTACAAAAGCATGCCAAAC
CTAGGCTCCAGAAACCACGTCCATCAGCTGCATACTTACTACCAGCTAGGTCGCGGCAGC
AGTGATGGATTTATAGTTCCTCCAAACAAAGATGGGACCCCTCCCGAGGGAAGTTCAAAA
GGACCGGCTCATTTGGTCACTAGTCTATAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:20974
Chromosome Location4
LocusNot Available
References
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