NameLysine-specific demethylase 4C
Synonyms
  • 1.14.11.-
  • GASC-1 protein
  • GASC1
  • Gene amplified in squamous cell carcinoma 1 protein
  • JHDM3C
  • JmjC domain-containing histone demethylation protein 3C
  • JMJD2C
  • Jumonji domain-containing protein 2C
  • KIAA0780
Gene NameKDM4C
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009324|Lysine-specific demethylase 4C
MEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQC
YDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSGKYCTPRYLDYEDLE
RKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYF
GMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFL
RHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWID
YGKVAKLCTCRKDMVKISMDIFVRKFQPDRYQLWKQGKDIYTIDHTKPTPASTPEVKAWL
QRRRKVRKASRSFQCARSTSKRPKADEEEEVSDEVDGAEVPNPDSVTDDLKVSEKSEAAV
KLRNTEASSEEESSASRMQVEQNLSDHIKLSGNSCLSTSVTEDIKTEDDKAYAYRSVPSI
SSEADDSIPLSSGYEKPEKSDPSELSWPKSPESCSSVAESNGVLTEGEESDVESHGNGLE
PGEIPAVPSGERNSFKVPSIAEGENKTSKSWRHPLSRPPARSPMTLVKQQAPSDEELPEV
LSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSS
NEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAK
CCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNKWAHVMCAV
AVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTC
AHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVM
AVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGS
NIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADIIQGER
KRQRVLSSRFKNEYVADPVYRTFLKSSFQKKCQKRQ
Number of residues1056
Molecular Weight119980.795
Theoretical pINot Available
GO Classification
Functions
  • enzyme binding
  • androgen receptor binding
  • dioxygenase activity
  • histone demethylase activity (H3-K9 specific)
  • histone demethylase activity
  • zinc ion binding
Processes
  • positive regulation of cell proliferation
  • transcription, DNA-templated
  • regulation of transcription from RNA polymerase II promoter
  • chromatin organization
  • histone H3-K9 demethylation
  • small GTPase mediated signal transduction
Components
  • nucleoplasm
  • nuclear chromatin
General FunctionZinc ion binding
Specific FunctionHistone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ9H3R0
UniProtKB Entry NameKDM4C_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0020886|Lysine-specific demethylase 4C (KDM4C)
ATGGAGGTGGCCGAGGTGGAAAGTCCTCTGAACCCCAGCTGTAAGATAATGACCTTCAGA
CCCTCCATGGAGGAGTTCCGGGAGTTCAACAAATACCTTGCATACATGGAGTCTAAAGGA
GCCCATCGTGCGGGTCTTGCAAAGGTGATTCCTCCTAAGGAGTGGAAGCCAAGACAGTGC
TATGATGACATTGATAATTTGCTCATTCCAGCACCAATTCAGCAGATGGTCACAGGGCAG
TCAGGACTGTTCACTCAGTACAACATCCAGAAAAAAGCGATGACTGTGAAGGAGTTCAGG
CAGCTGGCCAACAGTGGCAAATATTGTACTCCAAGATACTTGGATTACGAAGATTTGGAG
CGCAAGTACTGGAAGAACTTAACTTTTGTGGCACCTATCTATGGTGCAGATATTAATGGG
AGCATATATGATGAGGGTGTGGATGAATGGAACATAGCTCGCCTCAATACAGTCTTGGAT
GTGGTTGAAGAAGAGTGTGGCATTTCTATTGAGGGTGTAAATACCCCATATCTCTATTTT
GGCATGTGGAAGACCACGTTTGCATGGCACACCGAAGACATGGACCTCTATAGCATTAAT
TATCTCCACTTTGGAGAGCCCAAGTCTTGGTATGCTATACCTCCGGAGCATGGAAAACGA
CTTGAAAGACTAGCTCAAGGTTTTTTCCCAAGCAGCTCCCAAGGGTGTGATGCATTTCTT
CGCCACAAGATGACATTGATTTCTCCATCAGTATTGAAGAAATATGGTATTCCCTTTGAC
AAGATAACCCAGGAGGCTGGAGAATTCATGATCACTTTCCCATATGGCTACCATGCTGGT
TTTAATCATGGTTTCAACTGTGCAGAATCTACAAATTTTGCTACTGTCAGATGGATTGAC
TATGGAAAAGTTGCCAAATTGTGCACTTGCAGGAAAGACATGGTGAAGATTTCAATGGAT
ATCTTTGTGAGGAAATTTCAGCCAGACAGATATCAGCTTTGGAAACAAGGAAAGGATATA
TACACCATTGATCACACGAAGCCTACTCCAGCATCCACCCCTGAAGTAAAAGCATGGCTG
CAGAGGAGGAGGAAAGTAAGAAAAGCATCCCGAAGCTTCCAGTGTGCTAGGTCTACCTCT
AAAAGGCCTAAGGCTGATGAGGAAGAGGAAGTGTCAGATGAAGTCGATGGGGCAGAGGTC
CCTAACCCCGACTCAGTCACAGATGACCTCAAGGTCAGTGAAAAGTCAGAAGCAGCAGTG
AAGCTGAGGAACACAGAAGCATCTTCAGAAGAAGAGTCATCTGCTAGCAGGATGCAGGTG
GAGCAGAATTTATCAGATCATATCAAACTCTCAGGAAACAGCTGCTTAAGTACATCTGTA
ACAGAAGACATAAAAACTGAGGATGACAAAGCTTATGCATATAGAAGTGTACCTTCTATA
TCCAGTGAGGCTGATGATTCCATTCCATTGTCTAGTGGCTATGAGAAGCCCGAGAAATCA
GACCCATCCGAGCTTTCATGGCCAAAGTCACCTGAGTCATGCTCATCAGTGGCAGAGAGT
AATGGTGTGTTAACAGAGGGAGAAGAGAGTGATGTGGAGAGCCATGGGAATGGCCTTGAA
CCTGGGGAAATCCCAGCGGTCCCCAGTGGAGAGAGAAATAGCTTCAAAGTCCCCAGTATA
GCAGAGGGAGAGAACAAAACCTCTAAGAGTTGGCGCCATCCACTTAGCAGGCCTCCAGCA
AGATCTCCGATGACTCTTGTGAAGCAGCAGGCGCCAAGTGATGAAGAATTGCCTGAGGTT
CTGTCCATTGAGGAGGAAGTGGAAGAAACAGAGTCTTGGGCGAAACCTCTCATCCACCTT
TGGCAGACGAAGTCCCCTAACTTCGCAGCTGAGCAAGAGTATAATGCAACAGTGGCCAGG
ATGAAGCCACACTGTGCCATCTGCACTCTGCTCATGCCGTACCACAAGCCAGATAGCAGC
AATGAAGAAAATGATGCTAGATGGGAGACAAAATTAGATGAAGTCGTTACATCGGAGGGA
AAGACTAAGCCCCTCATACCAGAGATGTGTTTTATTTATAGTGAAGAAAATATAGAATAT
TCTCCACCCAATGCCTTCCTTGAAGAGGATGGAACAAGTCTCCTTATTTCCTGTGCAAAG
TGCTGCGTACGGGTTCATGCAAGTTGTTATGGTATTCCTTCTCATGAGATCTGTGATGGA
TGGCTGTGTGCCCGGTGCAAAAGAAATGCGTGGACAGCAGAATGCTGTCTCTGCAATTTG
AGAGGAGGTGCTCTTAAGCAAACGAAGAACAATAAGTGGGCCCATGTCATGTGCGCCGTT
GCGGTCCCAGAAGTTCGATTCACTAATGTCCCAGAAAGGACACAAATAGATGTAGGCAGA
ATACCTTTACAGAGGTTAAAATTGGGAAGGCTGGGAATCTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:17071
Chromosome Location9
LocusNot Available
References
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