NameSmall conductance calcium-activated potassium channel protein 2
Synonyms
  • KCa2.2
  • SK2
Gene NameKCNN2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008406|Small conductance calcium-activated potassium channel protein 2
MSSCRYNGGVMRPLSNLSASRRNLHEMDSEAQPLQPPASVGGGGGASSPSAAAAAAAAVS
SSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGSGHGSSSGTKSSKKKNQNIGYK
LGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTII
LLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTAR
LAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRF
VMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIG
YGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVK
NAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLV
DLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFI
EAQMESYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
Number of residues579
Molecular Weight63759.03
Theoretical pI9.99
GO Classification
Functions
  • calmodulin binding
  • alpha-actinin binding
  • calcium-activated potassium channel activity
  • protein domain specific binding
  • small conductance calcium-activated potassium channel activity
  • protein homodimerization activity
Processes
  • regulation of potassium ion transmembrane transport
  • potassium ion transport
  • synaptic transmission
  • potassium ion transmembrane transport
Components
  • T-tubule
  • Z disc
  • neuronal cell body
  • dendritic spine
  • smooth endoplasmic reticulum
  • plasma membrane
  • cell surface
  • integral component of membrane
General FunctionSmall conductance calcium-activated potassium channel activity
Specific FunctionForms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
Pfam Domain Function
Transmembrane Regions138-158 168-188 214-234 256-276 305-325 374-394
GenBank Protein ID10334701
UniProtKB IDQ9H2S1
UniProtKB Entry NameKCNN2_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0019569|Small conductance calcium-activated potassium channel protein 2 (KCNN2)
ATGTGGTTGATATCAATAACTTTTCTCTCCATTGGTTATGGTGACATGGTACCTAACACA
TACTGTGGAAAAGGAGTCTGCTTACTTACTGGAATTATGGGTGCTGGTTGCACAGCCCTG
GTGGTAGCTGTAGTGGCAAGGAAGCTAGAACTTACCAAAGCAGAAAAACACGTGCACAAT
TTCATGATGGATACTCAGCTGACTAAAAGAGTAAAAAATGCAGCTGCCAATGTACTCAGG
GAAACATGGCTAATTTACAAAAATACAAAGCTAGTGAAAAAGATAGATCATGCAAAAGTA
AGAAAACATCAACGAAAATTCCTGCAAGCTATTCATCAATTAAGAAGTGTAAAAATGGAG
CAGAGGAAACTGAATGACCAAGCAAACACTTTGGTGGACTTGGCAAAGACCCAGAACATC
ATGTATGATATGATTTCTGACTTAAACGAAAGGAGTGAAGACTTCGAGAAGAGGATTGTT
ACCCTGGAAACAAAACTAGAGACTTTGATTGGTAGCATCCACGCCCTCCCTGGGCTCATA
AGCCAGACCATCAGGCAGCAGCAGAGAGATTTCATTGAGGCTCAGATGGAGAGCTACGAC
AAGCACGTCACTTACAATGCTGAGCGGTCCCGGTCCTCGTCCAGGAGGCGGCGGTCCTCT
TCCACAGCACCACCAACTTCATCAGAGAGTAGCTAG
GenBank Gene IDAF239613
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:6291
Chromosome Location5
Locus5q22.3
References
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