Small conductance calcium-activated potassium channel protein 2
Name | Small conductance calcium-activated potassium channel protein 2 |
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Synonyms |
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Gene Name | KCNN2 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0008406|Small conductance calcium-activated potassium channel protein 2 MSSCRYNGGVMRPLSNLSASRRNLHEMDSEAQPLQPPASVGGGGGASSPSAAAAAAAAVS SSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGSGHGSSSGTKSSKKKNQNIGYK LGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTII LLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTAR LAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRF VMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIG YGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVK NAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLV DLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFI EAQMESYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS |
Number of residues | 579 |
Molecular Weight | 63759.03 |
Theoretical pI | 9.99 |
GO Classification | Functions
Processes
Components
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General Function | Small conductance calcium-activated potassium channel activity |
Specific Function | Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. |
Pfam Domain Function | |
Transmembrane Regions | 138-158 168-188 214-234 256-276 305-325 374-394 |
GenBank Protein ID | 10334701 |
UniProtKB ID | Q9H2S1 |
UniProtKB Entry Name | KCNN2_HUMAN |
Cellular Location | Membrane |
Gene sequence | >lcl|BSEQ0019569|Small conductance calcium-activated potassium channel protein 2 (KCNN2) ATGTGGTTGATATCAATAACTTTTCTCTCCATTGGTTATGGTGACATGGTACCTAACACA TACTGTGGAAAAGGAGTCTGCTTACTTACTGGAATTATGGGTGCTGGTTGCACAGCCCTG GTGGTAGCTGTAGTGGCAAGGAAGCTAGAACTTACCAAAGCAGAAAAACACGTGCACAAT TTCATGATGGATACTCAGCTGACTAAAAGAGTAAAAAATGCAGCTGCCAATGTACTCAGG GAAACATGGCTAATTTACAAAAATACAAAGCTAGTGAAAAAGATAGATCATGCAAAAGTA AGAAAACATCAACGAAAATTCCTGCAAGCTATTCATCAATTAAGAAGTGTAAAAATGGAG CAGAGGAAACTGAATGACCAAGCAAACACTTTGGTGGACTTGGCAAAGACCCAGAACATC ATGTATGATATGATTTCTGACTTAAACGAAAGGAGTGAAGACTTCGAGAAGAGGATTGTT ACCCTGGAAACAAAACTAGAGACTTTGATTGGTAGCATCCACGCCCTCCCTGGGCTCATA AGCCAGACCATCAGGCAGCAGCAGAGAGATTTCATTGAGGCTCAGATGGAGAGCTACGAC AAGCACGTCACTTACAATGCTGAGCGGTCCCGGTCCTCGTCCAGGAGGCGGCGGTCCTCT TCCACAGCACCACCAACTTCATCAGAGAGTAGCTAG |
GenBank Gene ID | AF239613 |
GeneCard ID | Not Available |
GenAtlas ID | Not Available |
HGNC ID | HGNC:6291 |
Chromosome Location | 5 |
Locus | 5q22.3 |
References |
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