S-methylmethionine--homocysteine S-methyltransferase BHMT2

NameS-methylmethionine--homocysteine S-methyltransferase BHMT2
Synonyms
  • 2.1.1.10
  • Betaine--homocysteine S-methyltransferase 2
  • SMM-hcy methyltransferase
Gene NameBHMT2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004414|S-methylmethionine--homocysteine S-methyltransferase BHMT2
MAPAGRPGAKKGILERLESGEVVIGDGSFLITLEKRGYVKAGLWTPEAVIEHPDAVRQLH
MEFLRAGSNVMQTFTFSASEDNMESKWEDVNAAACDLAREVAGKGDALVAGGICQTSIYK
YQKDEARIKKLFRQQLEVFAWKNVDFLIAEYFEHVEEAVWAVEVLKESDRPVAVTMCIGP
EGDMHDITPGECAVRLVKAGASIVGVNCRFGPDTSLKTMELMKEGLEWAGLKAHLMVQPL
GFHAPDCGKEGFVDLPEYPFGLESRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRA
IAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARREYWENLLPASGRPFCPSLSK
PDF
Number of residues363
Molecular Weight40353.84
Theoretical pI5.68
GO Classification
Functions
  • S-adenosylmethionine-homocysteine S-methyltransferase activity
  • S-methylmethionine-homocysteine S-methyltransferase activity
  • zinc ion binding
Processes
  • small molecule metabolic process
  • S-adenosylmethionine metabolic process
  • sulfur amino acid metabolic process
  • L-methionine salvage
  • S-methylmethionine cycle
  • S-methylmethionine metabolic process
  • cellular nitrogen compound metabolic process
Components
  • cytosol
  • extracellular exosome
General FunctionZinc ion binding
Specific FunctionInvolved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID11907831
UniProtKB IDQ9H2M3
UniProtKB Entry NameBHMT2_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0011622|S-methylmethionine--homocysteine S-methyltransferase BHMT2 (BHMT2)
ATGGCACCTGCTGGACGCCCGGGGGCCAAGAAGGGGATTTTGGAGCGCCTGGAGAGTGGG
GAGGTTGTGATTGGAGATGGCAGCTTTCTCATTACTCTGGAGAAGAGAGGCTATGTGAAG
GCTGGGCTCTGGACTCCAGAGGCAGTGATAGAACACCCAGACGCAGTTCGTCAACTTCAC
ATGGAATTCTTGAGAGCAGGATCAAATGTCATGCAGACTTTTACCTTTTCTGCCAGTGAG
GACAATATGGAAAGCAAGTATTTTGAGCACGTTGAAGAAGCTGTGTGGGCTGTGGAAGTC
TTAAAAGAATCAGATAGACCCGTGGCAGTTACCATGTGCATAGGCCCAGAGGGAGACATG
CATGATATAACCCCCGGAGAATGTGCTGTGAGGCTGGTGAAGGCAGGGGCTTCCATCGTT
GGCGTGAACTGCCGCTTTGGGCCCGACACCAGCTTGAAGACGATGGAGCTCATGAAGGAG
GGTCTTGAGTGGGCAGGGCTGAAAGCGCACCTCATGGTGCAGCCTCTGGGGTTCCACGCG
CCTGACTGTGGCAAAGAGGGGTTTGTGGATCTCCCAGAATATCCCTTTGGACTGGAGTCC
AGAGTTGCCACCAGATGGGATATTCAAAAATACGCCAGAGAGGCCTACAACCTGGGGGTC
AGGTACATTGGCGGGTGCTGTGGATTTGAGCCCTACCACATCAGGGCAATTGCAGAGGAG
CTGGCCCCAGAAAGGGGCTTTTTGCCACCAGCTTCAGAAAAACACGGCAGCTGGGGAAGT
GGTTTGGACATGCACACCAAACCCTGGATTAGAGCAAGGGCTCGAAGGGAGTATTGGGAG
AATCTGCTGCCAGCTTCAGGCAGACCTTTCTGTCCTTCGCTGTCAAAGCCAGACTTCTAA
GenBank Gene IDAF257473
GeneCard IDNot Available
GenAtlas IDBHMT2
HGNC IDHGNC:1048
Chromosome Location5
Locus5q13
References
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