Aldehyde dehydrogenase family 8 member A1
Name | Aldehyde dehydrogenase family 8 member A1 |
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Synonyms |
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Gene Name | ALDH8A1 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0008833|Aldehyde dehydrogenase family 8 member A1 MAGTNALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS WSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASS SLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPS ELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERIT QLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIY SEFLKRFVEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDK LSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLA ATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEI KTITVKH |
Number of residues | 487 |
Molecular Weight | 53400.88 |
Theoretical pI | Not Available |
GO Classification | Functions
Processes
Components
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General Function | Retinal dehydrogenase activity |
Specific Function | Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro). |
Pfam Domain Function |
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Transmembrane Regions | Not Available |
GenBank Protein ID | Not Available |
UniProtKB ID | Q9H2A2 |
UniProtKB Entry Name | AL8A1_HUMAN |
Cellular Location | Cytoplasm |
Gene sequence | >lcl|BSEQ0013443|Aldehyde dehydrogenase family 8 member A1 (ALDH8A1) ATGGCTGGAACAAACGCACTTTTGATGCTGGAAAACTTCATAGATGGAAAATTTTTACCT TGTAGCTCATATATAGATTCTTACGACCCATCAACAGGGGAAGTGTATTGCAGAGTGCCA AATAGTGGAAAAGACGAGATCGAAGCCGCGGTCAAGGCCGCCAGAGAAGCCTTTCCCAGC TGGTCATCCCGCAGCCCCCAGGAGCGCTCACGGGTCCTGAACCAGGTGGCGGATTTGCTG GAGCAGTCCCTGGAGGAGTTTGCCCAGGCCGAGTCTAAAGACCAAGGGAAAACCTTAGCA CTGGCAAGAACCATGGACATTCCCCGGTCTGTGCAGAACTTCAGGTTCTTCGCTTCCTCC AGCCTGCACCACACGTCAGAGTGCACGCAGATGGACCACCTGGGCTGCATGCACTACACG GTGCGGGCCCCGGTGGGAGTCGGTGTTCCACCAGGTGTGGTCAATATTGTGTTTGGAACC GGGCCCAGGGTGGGTGAGGCCCTGGTGTCCCACCCAGAGGTGCCCCTGATCTCCTTCACC GGGAGCCAGCCCACCGCTGAGCGGATCACCCAGCTGAGCGCTCCCCACTGCAAAAAGCTC TCCCTGGAGCTGGGGGGCAAGAATCCTGCCATCATCTTTGAGGACGCCAACCTGGATGAG TGCATTCCGGCAACCGTCAGGTCCAGCTTTGCCAACCAGGGTGAAATCTGTCTCTGTACC AGCAGGATCTTTGTCCAGAAGAGCATCTATAGTGAATTTTTAAAGAGATTTGTAGAAGCT ACCAGAAAGTGGAAAGTCGGCATTCCCTCTGATCCACTGGTGAGCATAGGTGCTCTGATA AGTAAAGCACATTTGGAGAAAGTCAGAAGTTACGTCAAGAGAGCTCTTGCTGAAGGTGCC CAAATTTGGTGCGGTGAGGGAGTGGATAAGTTGAGCCTCCCTGCCAGGAACCAGGCAGGC TACTTTATGCTTCCCACGGTGATAACAGACATTAAGGATGAATCCTGCTGCATGACGGAA GAGATATTTGGTCCAGTGACGTGTGTCGTCCCCTTTGATAGTGAAGAGGAGGTGATTGAA AGAGCCAACAACGTTAAGTATGGGCTGGCGGCTACCGTGTGGTCCAGCAATGTGGGGCGC GTCCACCGGGTGGCTAAGAAGCTGCAGTCTGGCTTGGTCTGGACCAACTGCTGGCTCATC AGGGAGCTGAACCTTCCTTTCGGGGGGATGAAGAGTTCTGGAATAGGTAGAGAGGGAGCC AAGGACTCTTACGACTTCTTCACTGAGATCAAAACCATCACCGTTAAACACTGA |
GenBank Gene ID | Not Available |
GeneCard ID | Not Available |
GenAtlas ID | Not Available |
HGNC ID | HGNC:15471 |
Chromosome Location | 6 |
Locus | Not Available |
References |
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