Name1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Synonyms
  • 1.13.11.54
  • Acireductone dioxygenase (Fe(2+)-requiring)
  • ARD
  • Fe-ARD
  • Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1
  • MTCBP-1
  • MTCBP1
  • Sip-L
  • Submergence-induced protein-like factor
Gene NameADI1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009545|1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
MVQAWYMDDAPGDPRQPHRPDPGRPVGLEQLRRLGVLYWKLDADKYENDPELEKIRRERN
YSWMDIITICKDKLPNYEEKIKMFYEEHLHLDDEIRYILDGSGYFDVRDKEDQWIRIFME
KGDMVTLPAGIYHRFTVDEKNYTKAMRLFVGEPVWTAYNRPADHFEARGQYVKFLAQTA
Number of residues179
Molecular Weight21498.23
Theoretical pINot Available
GO Classification
Functions
  • metal ion binding
  • acireductone dioxygenase [iron(II)-requiring] activity
  • oxidoreductase activity
Processes
  • cellular nitrogen compound metabolic process
  • small molecule metabolic process
  • polyamine metabolic process
  • sulfur amino acid metabolic process
  • L-methionine biosynthetic process from methylthioadenosine
Components
  • cytosol
  • cytoplasm
  • nucleus
  • plasma membrane
General FunctionOxidoreductase activity
Specific FunctionCatalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ9BV57
UniProtKB Entry NameMTND_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0019603|1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (ADI1)
ATGTCCGTGAAATCTTCAAAACTTATGTTCCTCTGCCATGGCTCCAGCCGGTCCCTCCAT
TCGGGGTCCCTGACTTCCTGCAACACTGGAGTTTGTTGTTCACTGGATGCTGACAAATAT
GAGAATGATCCAGAATTAGAAAAGATCCGAAGAGAGAGGAACTACTCCTGGATGGACATC
ATAACCATATGCAAAGATAAACTACCAAATTATGAAGAAAAGATTAAGATGTTCTACGAG
GAGCATTTGCACTTGGACGATGAGATCCGCTACATCCTGGATGGCAGTGGGTACTTCGAT
GTGAGGGACAAGGAGGACCAGTGGATCCGGATCTTCATGGAGAAGGGAGACATGGTGACG
CTCCCCGCGGGGATCTATCACCGCTTCACGGTGGACGAGAAGAACTACACGAAGGCCATG
CGGCTGTTTGTGGGAGAACCGGTGTGGACAGCGTACAACCGGCCCGCTGACCATTTTGAA
GCCCGCGGGCAGTACGTGAAATTTCTGGCACAGACCGCCTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:30576
Chromosome Location2
LocusNot Available
References
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