Vitamin K epoxide reductase complex subunit 1

NameVitamin K epoxide reductase complex subunit 1
Synonyms
  • 1.17.4.4
  • Vitamin K1 2,3-epoxide reductase subunit 1
  • VKOR
Gene NameVKORC1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001422|Vitamin K epoxide reductase complex subunit 1
MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWG
RGFGLVEHVLGQDSILNQSNSIFGCIFYTLQLLLGCLRTRWASVLMLLSSLVSLAGSVYL
AWILFFVLYDFCIVCITTYAINVSLMWLSFRKVQEPQGKAKRH
Number of residues163
Molecular Weight18234.3
Theoretical pI9.58
GO Classification
Functions
  • quinone binding
  • vitamin-K-epoxide reductase (warfarin-sensitive) activity
Processes
  • post-translational protein modification
  • bone development
  • drug metabolic process
  • vitamin K metabolic process
  • blood coagulation
  • peptidyl-glutamic acid carboxylation
  • cellular protein metabolic process
Components
  • endoplasmic reticulum membrane
  • integral component of membrane
General FunctionVitamin-k-epoxide reductase (warfarin-sensitive) activity
Specific FunctionInvolved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.
Pfam Domain Function
Transmembrane Regions9-29 75-95 101-123 127-149
GenBank Protein ID40217983
UniProtKB IDQ9BQB6
UniProtKB Entry NameVKOR1_HUMAN
Cellular LocationEndoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0016184|Vitamin K epoxide reductase complex subunit 1 (VKORC1)
ATGGGCAGCACCTGGGGGAGCCCTGGCTGGGTGCGGCTCGCTCTTTGCCTGACGGGCTTA
GTGCTCTCGCTCTACGCGCTGCACGTGAAGGCGGCGCGCGCCCGGGACCGGGATTACCGC
GCGCTCTGCGACGTGGGCACCGCCATCAGCTGTTCGCGCGTCTTCTCCTCCAGGTGGGGC
AGGGGTTTCGGGCTGGTGGAGCATGTGCTGGGACAGGACAGCATCCTCAATCAATCCAAC
AGCATATTCGGTTGCATCTTCTACACACTACAGCTATTGTTAGGTTGCCTGCGGACACGC
TGGGCCTCTGTCCTGATGCTGCTGAGCTCCCTGGTGTCTCTCGCTGGTTCTGTCTACCTG
GCCTGGATCCTGTTCTTCGTGCTCTATGATTTCTGCATTGTTTGTATCACCACCTATGCT
ATCAACGTGAGCCTGATGTGGCTCAGTTTCCGGAAGGTCCAAGAACCCCAGGGCAAGGCT
AAGAGGCACTGA
GenBank Gene IDAY423044
GeneCard IDNot Available
GenAtlas IDVKORC1
HGNC IDHGNC:23663
Chromosome Location16
Locus16p11.2
References
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  2. Li T, Chang CY, Jin DY, Lin PJ, Khvorova A, Stafford DW: Identification of the gene for vitamin K epoxide reductase. Nature. 2004 Feb 5;427(6974):541-4. 14765195
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