Histone H2A type 1-J

NameHistone H2A type 1-J
Synonyms
  • H2AFE
  • Histone H2A/e
Gene NameHIST1H2AJ
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013490|Histone H2A type 1-J
MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKK
TESHHKTK
Number of residues128
Molecular Weight13936.175
Theoretical pINot Available
GO Classification
Functions
  • DNA binding
Processes
  • chromatin silencing
  • chromatin organization
Components
  • nucleus
  • extracellular exosome
  • nuclear chromatin
  • nucleosome
General FunctionDna binding
Specific FunctionCore component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ99878
UniProtKB Entry NameH2A1J_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013491|Histone H2A type 1-J (HIST1H2AJ)
ATGTCTGGGCGTGGTAAGCAGGGAGGCAAAGCTCGCGCCAAGGCCAAGACCCGCTCTTCT
CGGGCCGGGCTTCAGTTTCCCGTAGGCCGAGTGCATCGCCTGCTCCGCAAAGGCAACTAT
GCGGAGCGGGTCGGTGCTGGAGCGCCGGTGTACCTGGCGGCGGTGCTGGAGTACCTGACC
GCCGAGATCCTGGAGCTGGCTGGCAACGCGGCCCGCGACAACAAGAAGACTCGCATCATC
CCGCGTCACCTCCAGCTGGCCATCCGCAACGATGAGGAGCTCAACAAGCTTCTGGGCAAA
GTCACCATCGCACAGGGTGGCGTCCTGCCCAACATCCAGGCCGTGCTGCTGCCAAAGAAA
ACTGAGAGCCACCACAAGACTAAGTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:4727
Chromosome Location6
LocusNot Available
References
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