Protein arginine N-methyltransferase 1

NameProtein arginine N-methyltransferase 1
Synonyms
  • 2.1.1.319
  • Histone-arginine N-methyltransferase PRMT1
  • HMT2
  • HRMT1L2
  • Interferon receptor 1-bound protein 4
  • IR1B4
Gene NamePRMT1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009518|Protein arginine N-methyltransferase 1
MENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDE
VRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIV
KANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGL
IFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNAC
LIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYT
HWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRM
R
Number of residues361
Molecular Weight41515.2
Theoretical pINot Available
GO Classification
Functions
  • identical protein binding
  • poly(A) RNA binding
  • methyltransferase activity
  • protein-arginine N-methyltransferase activity
  • protein-arginine omega-N asymmetric methyltransferase activity
  • N-methyltransferase activity
  • protein methyltransferase activity
  • histone methyltransferase activity
  • enzyme binding
  • histone methyltransferase activity (H4-R3 specific)
  • mitogen-activated protein kinase p38 binding
Processes
  • histone H4-R3 methylation
  • regulation of transcription, DNA-templated
  • histone methylation
  • peptidyl-arginine methylation
  • cell surface receptor signaling pathway
  • positive regulation of hemoglobin biosynthetic process
  • neuron projection development
  • protein methylation
  • negative regulation of megakaryocyte differentiation
  • chromatin organization
  • positive regulation of p38MAPK cascade
  • positive regulation of erythrocyte differentiation
  • peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
Components
  • cytoplasm
  • nucleus
  • cytosol
  • nucleoplasm
General FunctionProtein-arginine omega-n asymmetric methyltransferase activity
Specific FunctionArginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ99873
UniProtKB Entry NameANM1_HUMAN
Cellular LocationNucleus
Gene sequenceNot Available
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:5187
Chromosome LocationNot Available
LocusNot Available
References
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