Microsomal glutathione S-transferase 2

NameMicrosomal glutathione S-transferase 2
Synonyms
  • 2.5.1.18
  • GST2
  • Microsomal GST-2
  • Microsomal GST-II
Gene NameMGST2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004496|Microsomal glutathione S-transferase 2
MAGNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFY
PIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTL
LGALGIANSFLDEYLDLNIAKKLRRQF
Number of residues147
Molecular Weight16620.4
Theoretical pI9.88
GO Classification
Functions
  • leukotriene-C4 synthase activity
  • glutathione transferase activity
  • glutathione peroxidase activity
  • enzyme activator activity
Processes
  • small molecule metabolic process
  • leukotriene biosynthetic process
  • oxidation-reduction process
  • xenobiotic metabolic process
  • glutathione biosynthetic process
  • glutathione derivative biosynthetic process
Components
  • plasma membrane
  • endoplasmic reticulum membrane
  • integral component of membrane
  • intracellular membrane-bounded organelle
  • nuclear envelope
General FunctionLeukotriene-c4 synthase activity
Specific FunctionCan catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione.
Pfam Domain Function
Transmembrane Regions6-26 59-79 111-131
GenBank Protein ID1747521
UniProtKB IDQ99735
UniProtKB Entry NameMGST2_HUMAN
Cellular LocationEndoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0016743|Microsomal glutathione S-transferase 2 (MGST2)
ATGGCCGGGAACTCGATCCTGCTGGCTGCTGTCTCTATTCTCTCGGCCTGTCAGCAAAGT
TATTTTGCTTTGCAAGTTGGAAAGGCAAGATTAAAATACAAAGTTACGCCCCCAGCAGTC
ACTGGGTCACCAGAGTTTGAGAGAGTATTTCGGGCACAACAAAACTGTGTGGAGTTTTAT
CCTATATTCATAATTACATTGTGGATGGCTGGGTGGTATTTCAACCAAGTTTTTGCTACT
TGTCTGGGTCTGGTGTACATATATGGCCGTCACCTATACTTCTGGGGATATTCAGAAGCT
GCTAAAAAACGGATCACCGGTTTCCGACTGAGTCTGGGGATTTTGGCCTTGTTGACCCTC
CTAGGTGCCCTGGGAATTGCAAACAGCTTTCTGGATGAATATCTGGACCTCAATATTGCC
AAGAAACTGAGGCGGCAATTCTAA
GenBank Gene IDU77604
GeneCard IDNot Available
GenAtlas IDMGST2
HGNC IDHGNC:7063
Chromosome Location4
Locus4q28.3
References
  1. Jakobsson PJ, Mancini JA, Ford-Hutchinson AW: Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase. J Biol Chem. 1996 Sep 6;271(36):22203-10. 8703034
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