NameMelanin-concentrating hormone receptor 1
Synonyms
  • G-protein coupled receptor 24
  • GPR24
  • MCH receptor 1
  • MCH-1R
  • MCH1R
  • MCHR
  • SLC-1
  • SLC1
  • Somatostatin receptor-like protein
Gene NameMCHR1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0006750|Melanin-concentrating hormone receptor 1
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARL
WEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTIC
LLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHF
GETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALS
FISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRI
LQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVY
LYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESK
GT
Number of residues422
Molecular Weight45962.185
Theoretical pI9.13
GO Classification
Functions
  • G-protein coupled receptor activity
  • neuropeptide receptor activity
  • melanin-concentrating hormone receptor activity
Processes
  • feeding behavior
  • generation of precursor metabolites and energy
  • positive regulation of cytosolic calcium ion concentration
  • G-protein coupled receptor signaling pathway
  • cell surface receptor signaling pathway
  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
Components
  • ciliary membrane
  • nonmotile primary cilium
  • plasma membrane
  • cytosol
  • integral component of plasma membrane
General FunctionNeuropeptide receptor activity
Specific FunctionReceptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.
Pfam Domain Function
Transmembrane Regions114-136 149-171 186-208 228-250 279-301 322-344 359-381
GenBank Protein IDNot Available
UniProtKB IDQ99705
UniProtKB Entry NameMCHR1_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0012427|Melanin-concentrating hormone receptor 1 (MCHR1)
ATGTCAGTGGGAGCCATGAAGAAGGGAGTGGGGAGGGCAGTTGGGCTTGGAGGCGGCAGC
GGCTGCCAGGCTACGGAGGAAGACCCCCTTCCCAACTGCGGGGCTTGCGCTCCGGGACAA
GGTGGCAGGCGCTGGAGGCTGCCGCAGCCTGCGTGGGTGGAGGGGAGCTCAGCTCGGTTG
TGGGAGCAGGCGACCGGCACTGGCTGGATGGACCTGGAAGCCTCGCTGCTGCCCACTGGT
CCCAACGCCAGCAACACCTCTGATGGCCCCGATAACCTCACTTCGGCAGGATCACCTCCT
CGCACGGGGAGCATCTCCTACATCAACATCATCATGCCTTCGGTGTTCGGCACCATCTGC
CTCCTGGGCATCATCGGGAACTCCACGGTCATCTTCGCGGTCGTGAAGAAGTCCAAGCTG
CACTGGTGCAACAACGTCCCCGACATCTTCATCATCAACCTCTCGGTAGTAGATCTCCTC
TTTCTCCTGGGCATGCCCTTCATGATCCACCAGCTCATGGGCAATGGGGTGTGGCACTTT
GGGGAGACCATGTGCACCCTCATCACGGCCATGGATGCCAATAGTCAGTTCACCAGCACC
TACATCCTGACCGCCATGGCCATTGACCGCTACCTGGCCACTGTCCACCCCATCTCTTCC
ACGAAGTTCCGGAAGCCCTCTGTGGCCACCCTGGTGATCTGCCTCCTGTGGGCCCTCTCC
TTCATCAGCATCACCCCTGTGTGGCTGTATGCCAGACTCATCCCCTTCCCAGGAGGTGCA
GTGGGCTGCGGCATACGCCTGCCCAACCCAGACACTGACCTCTACTGGTTCACCCTGTAC
CAGTTTTTCCTGGCCTTTGCCCTGCCTTTTGTGGTCATCACAGCCGCATACGTGAGGATC
CTGCAGCGCATGACGTCCTCAGTGGCCCCCGCCTCCCAGCGCAGCATCCGGCTGCGGACA
AAGAGGGTGACCCGCACAGCCATCGCCATCTGTCTGGTCTTCTTTGTGTGCTGGGCACCC
TACTATGTGCTACAGCTGACCCAGTTGTCCATCAGCCGCCCGACCCTCACCTTTGTCTAC
TTATACAATGCGGCCATCAGCTTGGGCTATGCCAACAGCTGCCTCAACCCCTTTGTGTAC
ATCGTGCTCTGTGAGACGTTCCGCAAACGCTTGGTCCTGTCGGTGAAGCCTGCAGCCCAG
GGGCAGCTTCGCGCTGTCAGCAACGCTCAGACGGCTGACGAGGAGAGGACAGAAAGCAAA
GGCACCTGA
GenBank Gene IDU71092
GeneCard IDNot Available
GenAtlas IDMCHR1
HGNC IDHGNC:4479
Chromosome Location22
LocusNot Available
References
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