NameMonoglyceride lipase
Synonyms
  • 3.1.1.23
  • HU-K5
  • Lysophospholipase homolog
  • Lysophospholipase-like
  • MAGL
  • MGL
  • Monoacylglycerol lipase
Gene NameMGLL
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009821|Monoglyceride lipase
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
Number of residues303
Molecular Weight33261.13
Theoretical pINot Available
GO Classification
Functions
  • lysophospholipase activity
  • acylglycerol lipase activity
  • protein homodimerization activity
Processes
  • inflammatory response
  • triglyceride catabolic process
  • regulation of signal transduction
  • platelet activation
  • acylglycerol acyl-chain remodeling
  • small molecule metabolic process
  • acylglycerol catabolic process
  • regulation of endocannabinoid signaling pathway
  • lipid metabolic process
  • regulation of inflammatory response
  • arachidonic acid metabolic process
  • fatty acid biosynthetic process
  • glycerophospholipid biosynthetic process
  • phospholipid metabolic process
  • regulation of sensory perception of pain
  • blood coagulation
Components
  • extrinsic component of membrane
  • plasma membrane
  • endoplasmic reticulum membrane
  • cytosol
  • nucleoplasm
  • membrane
General FunctionProtein homodimerization activity
Specific FunctionConverts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ99685
UniProtKB Entry NameMGLL_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0017841|Monoglyceride lipase (MGLL)
ATGCCAGAGGAAAGTTCCCCCAGGCGGACCCCGCAGAGCATTCCCTACCAGGACCTCCCT
CACCTGGTCAATGCAGACGGACAGTACCTCTTCTGCAGGTACTGGAAACCCACAGGCACA
CCCAAGGCCCTCATCTTTGTGTCCCATGGAGCCGGAGAGCACAGTGGCCGCTATGAAGAG
CTGGCTCGGATGCTGATGGGGCTGGACCTGCTGGTGTTCGCCCACGACCATGTTGGCCAC
GGACAGAGCGAAGGGGAGAGGATGGTAGTGTCTGACTTCCACGTTTTCGTCAGGGATGTG
TTGCAGCATGTGGATTCCATGCAGAAAGACTACCCTGGGCTTCCTGTCTTCCTTCTGGGC
CACTCCATGGGAGGCGCCATCGCCATCCTCACGGCCGCAGAGAGGCCGGGCCACTTCGCC
GGCATGGTACTCATTTCGCCTCTGGTTCTTGCCAATCCTGAATCTGCAACAACTTTCAAG
GTCCTTGCTGCGAAAGTGCTCAACCTTGTGCTGCCAAACTTGTCCCTCGGGCCCATCGAC
TCCAGCGTGCTCTCTCGGAATAAGACAGAGGTCGACATTTATAACTCAGACCCCCTGATC
TGCCGGGCAGGGCTGAAGGTGTGCTTCGGCATCCAACTGCTGAATGCCGTCTCACGGGTG
GAGCGCGCCCTCCCCAAGCTGACTGTGCCCTTCCTGCTGCTCCAGGGCTCTGCCGATCGC
CTATGTGACAGCAAAGGGGCCTACCTGCTCATGGAGTTAGCCAAGAGCCAGGACAAGACT
CTCAAGATTTATGAAGGTGCCTACCATGTTCTCCACAAGGAGCTTCCTGAAGTCACCAAC
TCCGTCTTCCATGAAATAAACATGTGGGTCTCTCAAAGGACAGCCACGGCAGGAACTGCG
TCCCCACCCTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:17038
Chromosome Location3
LocusNot Available
References
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