Protein S100-A13

NameProtein S100-A13
Synonyms
  • S100 calcium-binding protein A13
Gene NameS100A13
OrganismHuman
Amino acid sequence
>lcl|BSEQ0016239|Protein S100-A13
MAAEPLTELEESIETVVTTFFTFARQEGRKDSLSVNEFKELVTQQLPHLLKDVGSLDEKM
KSLDVNQDSELKFNEYWRLIGELAKEIRKKKDLKIRKK
Number of residues98
Molecular Weight11471.095
Theoretical pI5.96
GO Classification
Functions
  • fibroblast growth factor binding
  • zinc ion binding
  • RAGE receptor binding
  • copper ion binding
  • calcium ion binding
  • lipid binding
  • protein homodimerization activity
Processes
  • positive regulation of cell proliferation
  • response to copper ion
  • response to electrical stimulus
  • positive regulation of I-kappaB kinase/NF-kappaB signaling
  • cytokine secretion
  • mast cell degranulation
  • interleukin-1 alpha secretion
  • regulation of cell shape
Components
  • perinuclear region of cytoplasm
  • mast cell granule
  • cytoplasm
  • nucleus
  • extracellular space
  • cytosol
  • extracellular exosome
General FunctionZinc ion binding
Specific FunctionPlays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID1694828
UniProtKB IDQ99584
UniProtKB Entry NameS10AD_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0016240|Protein S100-A13 (S100A13)
ATGGCAGCAGAACCACTGACAGAGCTAGAGGAGTCCATTGAGACCGTGGTCACCACCTTC
TTCACCTTTGCAAGGCAGGAGGGCCGGAAGGATAGCCTCAGCGTCAACGAGTTCAAAGAG
CTGGTTACCCAGCAGTTGCCCCATCTGCTCAAGGATGTGGGCTCTCTTGATGAGAAGATG
AAGAGCTTGGATGTGAATCAGGACTCGGAGCTCAAGTTCAATGAGTACTGGAGATTGATT
GGGGAGCTGGCCAAGGAAATCAGGAAGAAGAAAGACCTGAAGATCAGGAAGAAGTAA
GenBank Gene IDX99920
GeneCard IDNot Available
GenAtlas IDS100A13
HGNC IDHGNC:10490
Chromosome Location1
Locus1q21
References
  1. Wicki R, Schafer BW, Erne P, Heizmann CW: Characterization of the human and mouse cDNAs coding for S100A13, a new member of the S100 protein family. Biochem Biophys Res Commun. 1996 Oct 14;227(2):594-9. 8878558
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  4. Mandinova A, Soldi R, Graziani I, Bagala C, Bellum S, Landriscina M, Tarantini F, Prudovsky I, Maciag T: S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells. J Cell Sci. 2003 Jul 1;116(Pt 13):2687-96. Epub 2003 May 13. 12746488
  5. Cao R, Yan B, Yang H, Zu X, Wen G, Zhong J: Effect of human S100A13 gene silencing on FGF-1 transportation in human endothelial cells. J Formos Med Assoc. 2010 Sep;109(9):632-40. doi: 10.1016/S0929-6646(10)60103-9. 20863990
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  7. Arnesano F, Banci L, Bertini I, Fantoni A, Tenori L, Viezzoli MS: Structural interplay between calcium(II) and copper(II) binding to S100A13 protein. Angew Chem Int Ed Engl. 2005 Oct 7;44(39):6341-4. 16145699
  8. Li M, Zhang PF, Pan XW, Chang WR: Crystal structure study on human S100A13 at 2.0 A resolution. Biochem Biophys Res Commun. 2007 May 11;356(3):616-21. Epub 2007 Mar 12. 17374362
  9. Imai FL, Nagata K, Yonezawa N, Nakano M, Tanokura M: Structure of calcium-bound human S100A13 at pH 7.5 at 1.8 A resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Feb 1;64(Pt 2):70-6. doi: 10.1107/S1744309107068236. Epub 2008 Jan 31. 18259052
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