NameSphingosine 1-phosphate receptor 3
Synonyms
  • EDG3
  • Endothelial differentiation G-protein coupled receptor 3
  • S1P receptor 3
  • S1P receptor Edg-3
  • Sphingosine 1-phosphate receptor Edg-3
Gene NameS1PR3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0021466|Sphingosine 1-phosphate receptor 3
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMV
LIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFV
ALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLH
NLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMA
LLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTL
ASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAP
SSCIMDKNAALQNGIFCN
Number of residues378
Molecular Weight42249.805
Theoretical pINot Available
GO Classification
Functions
  • integrin binding
  • sphingosine-1-phosphate receptor activity
  • G-protein coupled receptor activity
  • lipid binding
Processes
  • inflammatory response
  • positive regulation of cytosolic calcium ion concentration
  • G-protein coupled receptor signaling pathway
  • positive regulation of cell proliferation
  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
  • anatomical structure morphogenesis
  • Notch signaling pathway
  • regulation of interleukin-1 beta production
  • cytokine production
  • negative regulation of establishment of endothelial barrier
Components
  • plasma membrane
  • cytosol
  • integral component of plasma membrane
General FunctionSphingosine-1-phosphate receptor activity
Specific FunctionReceptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.
Pfam Domain Function
Transmembrane Regions41-65 73-101 116-134 154-179 196-216 244-265 282-302
GenBank Protein IDNot Available
UniProtKB IDQ99500
UniProtKB Entry NameS1PR3_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0021467|Sphingosine 1-phosphate receptor 3 (S1PR3)
ATGGCAACTGCCCTCCCGCCGCGTCTCCAGCCGGTGCGGGGGAACGAGACCCTGCGGGAG
CATTACCAGTACGTGGGGAAGTTGGCGGGCAGGCTGAAGGAGGCCTCCGAGGGCAGCACG
CTCACCACCGTGCTCTTCTTGGTCATCTGCAGCTTCATCGTCTTGGAGAACCTGATGGTT
TTGATTGCCATCTGGAAAAACAATAAATTTCACAACCGCATGTACTTTTTCATTGGCAAC
CTGGCTCTCTGCGACCTGCTGGCCGGCATCGCTTACAAGGTCAACATTCTGATGTCTGGC
AAGAAGACGTTCAGCCTGTCTCCCACGGTCTGGTTCCTCAGGGAGGGCAGTATGTTCGTG
GCCCTTGGGGCGTCCACCTGCAGCTTACTGGCCATCGCCATCGAGCGGCACTTGACAATG
ATCAAAATGAGGCCTTACGACGCCAACAAGAGGCACCGCGTCTTCCTCCTGATCGGGATG
TGCTGGCTCATTGCCTTCACGCTGGGCGCCCTGCCCATTCTGGGCTGGAACTGCCTGCAC
AATCTCCCTGACTGCTCTACCATCCTGCCCCTCTACTCCAAGAAGTACATTGCCTTCTGC
ATCAGCATCTTCACGGCCATCCTGGTGACCATCGTGATCCTCTACGCACGCATCTACTTC
CTGGTGAAGTCCAGCAGCCGTAAGGTGGCCAACCACAACAACTCGGAGCGGTCCATGGCA
CTGCTGCGGACCGTGGTGATTGTGGTGAGCGTGTTCATCGCCTGCTGGTCCCCACTCTTC
ATCCTCTTCCTCATTGATGTGGCCTGCAGGGTGCAGGCGTGCCCCATCCTCTTCAAGGCT
CAGTGGTTCATCGTGTTGGCTGTGCTCAACTCCGCCATGAACCCGGTCATCTACACGCTG
GCCAGCAAGGAGATGCGGCGGGCCTTCTTCCGTCTGGTCTGCAACTGCCTGGTCAGGGGA
CGGGGGGCCCGCGCCTCACCCATCCAGCCTGCGCTCGACCCAAGCAGAAGTAAATCAAGC
AGCAGCAACAATAGCAGCCACTCTCCGAAGGTCAAGGAAGACCTGCCCCACACAGCCCCC
TCATCCTGCATCATGGACAAGAACGCAGCACTTCAGAATGGGATCTTCTGCAACTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:3167
Chromosome Location9
LocusNot Available
References
  1. Yamaguchi F, Tokuda M, Hatase O, Brenner S: Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9. Biochem Biophys Res Commun. 1996 Oct 14;227(2):608-14. 8878560
  2. An S, Bleu T, Huang W, Hallmark OG, Coughlin SR, Goetzl EJ: Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids. FEBS Lett. 1997 Nov 17;417(3):279-82. 9409733
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