T3DB: Kinesin-like protein KIF20B

Name	Kinesin-like protein KIF20B
Synonyms	Cancer/testis antigen 90 CT90 Kinesin family member 20B Kinesin-related motor interacting with PIN1 KRMP1 M-phase phosphoprotein 1 MPHOSPH1 MPP1
Gene Name	KIF20B
Organism	Human
Amino acid sequence	>lcl\|BSEQ0009141\|Kinesin-like protein KIF20B MESNFNQEGVPRPSYVFSADPIARPSEINFDGIKLDLSHEFSLVAPNTEANSFESKDYLQ VCLRIRPFTQSEKELESEGCVHILDSQTVVLKEPQCILGRLSEKSSGQMAQKFSFSKVFG PATTQKEFFQGCIMQPVKDLLKGQSRLIFTYGLTNSGKTYTFQGTEENIGILPRTLNVLF DSLQERLYTKMNLKPHRSREYLRLSSEQEKEEIASKSALLRQIKEVTVHNDSDDTLYGSL TNSLNISEFEESIKDYEQANLNMANSIKFSVWVSFFEIYNEYIYDLFVPVSSKFQKRKML RLSQDVKGYSFIKDLQWIQVSDSKEAYRLLKLGIKHQSVAFTKLNNASSRSHSIFTVKIL QIEDSEMSRVIRVSELSLCDLAGSERTMKTQNEGERLRETGNINTSLLTLGKCINVLKNS EKSKFQQHVPFRESKLTHYFQSFFNGKGKICMIVNISQCYLAYDETLNVLKFSAIAQKVC VPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELE NAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFK IREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDIC ATKVETEETHNYVGFEDIIDSLQDNVADIKKQAEIAHLYIASLPDPQEATACLELKFNQI KAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTI NEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQ QDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKN EKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEK IMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDN LPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEE LEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQ HVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERN LKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKL KEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKI NELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMT LEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGK LTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNE MEILTAQLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETSKI ETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVVLDSCEVSTENDQSTRFPK PELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKARKRKSNEMEEDLVKCENKKNATPRTNL KFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKKKEGTLQKFGDFLQHS PSILQSKAKKIIETMSSSKLSNVEASKENVSQPKRAKRKLYTSEISSPIDISGQVILMDQ KMKESDHQIIKRRLRTKTAK
Number of residues	1820
Molecular Weight	210627.785
Theoretical pI	Not Available
GO Classification	Functions ATPase activity protein homodimerization activity microtubule binding ATP-dependent microtubule motor activity, plus-end-directed WW domain binding ATP binding Processes microtubule-based movement positive regulation of neuron migration neural tube closure positive regulation of cytokinesis regulation of establishment of cell polarity cell cycle arrest cell division neuron projection morphogenesis mitotic nuclear division positive regulation of cell proliferation protein localization to microtubule positive regulation of intracellular protein transport positive regulation of mitotic cytokinetic process regulation of mitotic nuclear division Components axon microtubule nucleus centrosome midbody nucleolus kinesin complex nucleoplasm perinuclear region of cytoplasm mitotic spindle midzone spindle midzone contractile ring growth cone cytoplasm mitotic spindle pole
General Function	Ww domain binding
Specific Function	Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436).
Pfam Domain Function	Kinesin (PF00225 )
Transmembrane Regions	Not Available
GenBank Protein ID	Not Available
UniProtKB ID	Q96Q89
UniProtKB Entry Name	KI20B_HUMAN
Cellular Location	Nucleus
Gene sequence	>lcl\|BSEQ0021439\|Kinesin-like protein KIF20B (KIF20B) ATGGAATCTAATTTTAATCAAGAGGGAGTACCTCGACCATCTTATGTTTTTAGTGCTGAC CCAATTGCAAGGCCTTCAGAAATAAATTTCGATGGCATTAAGCTTGATCTGTCTCATGAA TTTTCCTTAGTTGCTCCAAATACTGAGGCAAACAGTTTCGAATCTAAAGATTATCTCCAG GTTTGTCTTCGAATAAGACCATTTACACAGTCAGAAAAAGAACTTGAGTCTGAGGGCTGT GTGCATATTCTGGATTCACAGACTGTTGTGCTGAAAGAGCCTCAATGCATCCTTGGTCGG TTAAGTGAAAAAAGCTCAGGGCAGATGGCACAGAAATTCAGTTTTTCCAAGGTTTTTGGC CCAGCAACTACACAGAAGGAATTCTTTCAGGGTTGCATTATGCAACCAGTAAAAGACCTC TTGAAAGGACAGAGTCGTCTGATTTTTACTTACGGGCTAACCAATTCAGGAAAAACATAT ACATTTCAAGGGACAGAAGAAAATATTGGCATTCTGCCTCGAACTTTGAATGTATTATTT GATAGTCTTCAAGAAAGACTGTATACAAAGATGAACCTTAAACCACATAGATCCAGAGAA TACTTAAGGTTATCATCAGAACAAGAGAAAGAAGAAATTGCTAGCAAAAGTGCATTGCTT CGGCAAATTAAAGAGGTTACTGTGCATAATGATAGTGATGATACTCTTTATGGAAGTTTA ACTAACTCTTTGAATATCTCAGAGTTTGAAGAATCCATAAAAGATTATGAACAAGCCAAC TTGAATATGGCTAATAGTATAAAATTTTCTGTGTGGGTTTCTTTCTTTGAAATTTACAAT GAATATATTTATGACTTATTTGTTCCTGTATCATCTAAATTCCAAAAGAGAAAGATGCTG CGCCTTTCCCAAGACGTAAAGGGCTATTCTTTTATAAAAGATCTACAATGGATTCAAGTA TCTGATTCCAAAGAAGCCTATAGACTTTTAAAACTAGGAATAAAGCACCAGAGTGTTGCC TTCACAAAATTGAATAATGCTTCCAGTAGAAGTCACAGCATATTCACTGTTAAAATATTA CAGATTGAAGATTCTGAAATGTCTCGTGTAATTCGAGTCAGTGAATTATCTTTATGTGAT CTTGCTGGTTCAGAACGAACTATGAAGACACAGAATGAAGGTGAAAGGTTAAGAGAGACT GGGAATATCAACACTTCTTTATTGACTCTGGGAAAGTGTATTAACGTCTTGAAGAATAGT GAAAAGTCAAAGTTTCAACAGCATGTGCCTTTCCGGGAAAGTAAACTGACTCACTATTTT CAAAGTTTTTTTAATGGTAAAGGGAAAATTTGTATGATTGTCAATATCAGCCAATGTTAT TTAGCCTATGATGAAACACTCAATGTATTGAAGTTCTCCGCCATTGCACAAAAAGTTTGT GTCCCAGACACTTTAAATTCCTCTCAAGAGAAATTATTTGGACCTGTCAAATCTTCTCAA GATGTATCACTAGACAGTAATTCAAACAGTAAAATATTAAATGTAAAAAGAGCCACCATT TCATGGGAAAATAGTCTAGAAGATTTGATGGAAGACGAGGATTTGGTTGAGGAGCTAGAA AACGCTGAAGAAACTCAAAATGTGGAAACTAAACTTCTTGATGAAGATCTAGATAAAACA TTAGAGGAAAATAAGGCTTTCATTAGCCACGAGGAGAAAAGAAAACTGTTGGACTTAATA GAAGACTTGAAAAAAAAACTGATAAATGAAAAAAAGGAAAAATTAACCTTGGAATTTAAA ATTCGAGAAGAAGTTACACAGGAGTTTACTCAGTATTGGGCTCAACGGGAAGCTGACTTT AAGGAGACTCTGCTTCAAGAACGAGAGATATTAGAAGAAAATGCTGAACGTCGTTTGGCT ATCTTCAAGGATTTGGTTGGTAAATGTGACACTCGAGAAGAAGCAGCGAAAGACATTTGT GCCACAAAAGTTGAAACTGAAGAAACACATAATTATGTAGGATTTGAAGATATTATTGAT TCTCTTCAAGATAATGTTGCTGATATTAAGAAACAGGCTGAAATTGCTCACTTATATATT GCATCTCTTCCTGACCCCCAGGAAGCTACTGCTTGTTTAGAACTAAAGTTTAATCAAATT AAAGCTGAATTAGCTAAAACCAAAGGAGAATTAATCAAAACCAAAGAAGAGTTAAAAAAG AGAGAAAATGAATCAGATTCATTGATTCAAGAGCTTGAGACATCTAATAAGAAAATAATT ACACAGAATCAAAGAATTAAAGAATTGATAAATATAATTGATCAAAAAGAAGATACTATC AACGAATTTCAGAACCTAAAGTCTCATATGGAAAACACATTTAAATGCAATGACAAGGCT GATACATCTTCTTTAATAATAAACAATAAATTGATTTGTAATGAAACAGTTGAAGTACCT AAGGACAGCAAATCTAAAATCTGTTCAGAAAGAAAAAGAGTAAATGAAAATGAACTTCAG CAAGATGAACCACCAGCAAAGAAAGGGTCTATCCATGTTAGTTCAGCTATCACTGAAGAC CAAAAGAAAAGTGAAGAAGTGCGACCGAACATTGCAGAAATTGAAGACATCAGAGTTTTA CAAGAAAATAATGAAGGACTGAGAGCATTTTTACTCACTATTGAGAATGAACTTAAAAAT GAAAAGGAAGAAAAAGCAGAATTAAATAAACAGATTGTTCATTTTCAGCAGGAACTTTCT CTTTCTGAAAAAAAGAATTTAACTTTAAGTAAAGAGGTCCAACAAATTCAGTCAAATTAT GATATTGCAATTGCTGAATTACATGTGCAGAAAAGTAAAAATCAAGAACAGGAGGAAAAG ATCATGAAATTGTCAAATGAGATAGAAACTGCTACAAGAAGCATTACAAATAATGTTTCA CAAATAAAATTAATGCACACGAAAATAGACGAACTACGTACTCTTGATTCAGTTTCTCAG ATTTCAAACATAGATTTGCTCAATCTCAGGGATCTGTCAAATGGTTCTGAGGAGGATAAT TTGCCAAATACACAGTTAGACCTTTTAGGTAATGATTATTTGGTAAGTAAGCAAGTTAAA GAATATCGAATTCAAGAACCCAATAGGGAAAATTCTTTCCACTCTAGTATTGAAGCTATT TGGGAAGAATGTAAAGAGATTGTGAAGGCCTCTTCCAAAAAAAGTCATCAGATTGAGGAA CTGGAACAACAAATTGAAAAATTGCAGGCAGAAGTAAAAGGCTATAAGGATGAAAACAAT AGACTAAAGGAGAAGGAGCATAAAAACCAAGATGACCTACTAAAAGAAAAAGAAACTCTT ATACAGCAGCTGAAAGAAGAATTGCAAGAAAAAAATGTTACTCTTGATGTTCAAATACAG CATGTAGTTGAAGGAAAGAGAGCGCTTTCAGAACTTACACAAGGTGTTACTTGCTATAAG GCAAAAATAAAGGAACTTGAAACAATTTTAGAGACTCAGAAAGTTGAATGTAGTCATTCA GCCAAGTTAGAACAAGACATTTTGGAAAAGGAATCTATCATCTTAAAGCTAGAAAGAAAT TTGAAGGAATTTCAAGAACATCTTCAGGATTCTGTCAAAAACACCAAAGATTTAAATGTA AAGGAACTCAAGCTGAAAGAAGAAATCACACAGTTAACAAATAATTTGCAAGATATGAAA CATTTACTTCAATTAAAAGAAGAAGAAGAAGAAACCAACAGGCAAGAAACAGAAAAATTG AAAGAGGAACTCTCTGCAAGCTCTGCTCGTACCCAGAATCTGAAAGCAGATCTTCAGAGG AAGGAAGAAGATTATGCTGACCTGAAAGAGAAACTGACTGATGCCAAAAAGCAGATTAAG CAAGTACAGAAAGAGGTATCTGTAATGCGTGATGAGGATAAATTACTGAGGATTAAAATT AATGAACTGGAGAAAAAGAAAAACCAGTGTTCTCAGGAATTAGATATGAAACAGCGAACC ATTCAGCAACTCAAGGAGCAGTTAAATAATCAGAAAGTGGAAGAAGCTATACAACAGTAT GAGAGAGCATGCAAAGATCTAAATGTTAAAGAGAAAATAATTGAAGACATGCGAATGACA CTAGAAGAACAGGAACAAACTCAGGTAGAACAGGATCAAGTGCTTGAGGCTAAATTAGAG GAAGTTGAAAGGCTGGCCACAGAATTGGAAAAATGGAAGGAAAAATGCAATGATTTGGAA ACCAAAAACAATCAAAGGTCAAATAAAGAACATGAGAACAACACAGATGTGCTTGGAAAG CTCACTAATCTTCAAGATGAGTTACAGGAGTCTGAACAGAAATATAATGCTGATAGAAAG AAATGGTTAGAAGAAAAAATGATGCTTATCACTCAAGCGAAAGAAGCAGAGAATATACGA AATAAAGAGATGAAAAAATATGCTGAGGACAGGGAGCGTTTTTTTAAGCAACAGAATGAA ATGGAAATACTGACAGCCCAGCTGACAGAGAAAGATAGTGACCTTCAAAAGTGGCGAGAA GAACGAGATCAACTGGTTGCAGCTTTAGAAATACAGCTAAAAGCACTGATATCCAGTAAT GTACAGAAAGATAATGAAATTGAACAACTAAAAAGGATCATATCAGAGACTTCTAAAATA GAAACACAAATCATGGATATCAAGCCCAAACGTATTAGTTCAGCAGATCCTGACAAACTT CAAACTGAACCTCTATCGACAAGTTTTGAAATTTCCAGAAATAAAATAGAGGATGGATCT GTAGTCCTTGACTCTTGTGAAGTGTCAACAGAAAATGATCAAAGCACTCGATTTCCAAAA CCTGAGTTAGAGATTCAATTTACACCTTTACAGCCAAACAAAATGGCAGTGAAACACCCT GGTTGTACCACACCAGTGACAGTTAAGATTCCCAAGGCTCGGAAGAGGAAGAGTAATGAA ATGGAGGAGGACTTGGTGAAATGTGAAAATAAGAAGAATGCTACACCCAGAACTAATTTG AAATTTCCTATTTCAGATGATAGAAATTCTTCTGTCAAAAAGGAACAAAAGGTTGCCATA CGTCCATCATCTAAGAAAACATATTCTTTACGGAGTCAGGCATCCATAATTGGTGTAAAC CTGGCCACTAAGAAAAAAGAAGGAACACTACAGAAATTTGGAGACTTCTTACAACATTCT CCCTCAATTCTTCAATCAAAAGCAAAGAAGATAATTGAAACAATGAGCTCTTCAAAGCTC TCAAATGTAGAAGCAAGTAAAGAAAATGTGTCTCAACCAAAACGAGCCAAACGGAAATTA TACACAAGTGAAATTTCATCTCCTATTGATATATCAGGCCAAGTGATTTTAATGGACCAG AAAATGAAGGAGAGTGATCACCAGATTATCAAACGACGACTTCGAACAAAAACAGCCAAA TAA
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:7212
Chromosome Location	10
Locus	Not Available
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