Adenylate cyclase type 10

NameAdenylate cyclase type 10
Synonyms
  • 4.6.1.1
  • Adenylate cyclase homolog
  • AH-related protein
  • Germ cell soluble adenylyl cyclase
  • hsAC
  • SAC
  • Testicular soluble adenylyl cyclase
Gene NameADCY10
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008830|Adenylate cyclase type 10
MNTPKEEFQDWPIVRIAAHLPDLIVYGHFSPERPFMDYFDGVLMFVDISGFTAMTEKFSS
AMYMDRGAEQLVEILNYHISAIVEKVLIFGGDILKFAGDALLALWRVERKQLKNIITVVI
KCSLEIHGLFETQEWEEGLDIRVKIGLAAGHISMLVFGDETHSHFLVIGQAVDDVRLAQN
MAQMNDVILSPNCWQLCDRSMIEIESVPDQRAVKVNFLKPPPNFNFDEFFTKCTTFMHYY
PSGEHKNLLRLACTLKPDPELEMSLQKYVMESILKQIDNKQLQGYLSELRPVTIVFVNLM
FEDQDKAEEIGPAIQDAYMHITSVLKIFQGQINKVFMFDKGCSFLCVFGFPGEKVPDELT
HALECAMDIFDFCSQVHKIQTVSIGVASGIVFCGIVGHTVRHEYTVIGQKVNLAARMMMY
YPGIVTCDSVTYNGSNLPAYFFKELPKKVMKGVADSGPLYQYWGRTEKVMFGMACLICNR
KEDYPLLGRNKEINYFMYTMKKFLISNSSQVLMYEGLPGYGKSQILMKIEYLAQGKNHRI
IAISLNKISFHQTFYTIQMFMANVLGLDTCKHYKERQTNLRNKVMTLLDEKFYCLLNDIF
HVQFPISREISRMSTLKKQKQLEILFMKILKLIVKEERIIFIIDEAQFVDSTSWRFMEKL
IRTLPIFIIMSLCPFVNIPCAAARAVIKNRNTTYIVIGAVQPNDISNKICLDLNVSCISK
ELDSYLGEGSCGIPFYCEELLKNLEHHEVLVFQQTESEEKTNRTWNNLFKYSIKLTEKLN
MVTLHSDKESEEVCHLTSGVRLKNLSPPTSLKEISLIQLDSMRLSHQMLVRCAAIIGLTF
TTELLFEILPCWNMKMMIKTLATLVESNIFYCFRNGKELQKALKQNDPSFEVHYRSLSLK
PSEGMDHGEEEQLRELENEVIECHRIRFCNPMMQKTAYELWLKDQRKAMHLKCARFLEED
AHRCDHCRGRDFIPYHHFTVNIRLNALDMDAIKKMAMSHGFKTEEKLILSNSEIPETSAF
FPENRSPEEIREKILNFFDHVLTKMKTSDEDIIPLESCQCEEILEIVILPLAHHFLALGE
NDKALYYFLEIASAYLIFCDNYMAYMYLNEGQKLLKTLKKDKSWSQTFESATFYSLKGEV
CFNMGQIVLAKKMLRKALKLLNRIFPYNLISLFLHIHVEKNRHFHYVNRQAQESPPPGKK
RLAQLYRQTVCLSLLWRIYSYSYLFHCKYYAHLAVMMQMNTALETQNCFQIIKAYLDYSL
YHHLAGYKGVWFKYEVMAMEHIFNLPLKGEGIEIVAYVAETLVFNKLIMGHLDLAIELGS
RALQMWALLQNPNRHYQSLCRLSRCLLLNSRYPQLIQVLGRLWELSVTQEHIFSKAFFYF
VCLDILLYSGFVYRTFEECLEFIHQYENNRILKFHSGLLLGLYSSVAIWYARLQEWDNFY
KFSNRAKNLLPRRTMTLTYYDGISRYMEGQVLHLQKQIKEQSENAQASGEELLKNLENLV
AQNTTGPVFCPRLYHLMAYVCILMGDGQKCGLFLNTALRLSETQGNILEKCWLNMNKESW
YSTSELKEDQWLQTILSLPSWEKIVAGRVNIQDLQKNKFLMRANTVDNHF
Number of residues1610
Molecular Weight187147.545
Theoretical pINot Available
GO Classification
Functions
  • adenylate cyclase activity
  • manganese ion binding
  • magnesium ion binding
  • bicarbonate binding
  • ATP binding
Processes
  • cAMP biosynthetic process
  • cellular response to inorganic substance
  • epithelial cilium movement
  • positive regulation of apoptotic process
  • intracellular signal transduction
  • spermatogenesis
Components
  • cytoskeleton
  • nucleus
  • cilium
  • plasma membrane
  • basal part of cell
  • cytosol
  • perinuclear region of cytoplasm
  • dendrite
  • growth cone
  • neuronal cell body
  • apical part of cell
  • cytoplasm
  • axon
  • mitochondrion
General FunctionManganese ion binding
Specific FunctionCatalyzes the formation of the signaling molecule cAMP (PubMed:12609998, PubMed:15659711, PubMed:24616449, PubMed:25040695, PubMed:24567411). May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (PubMed:15659711, PubMed:17591988). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (PubMed:17591988).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ96PN6
UniProtKB Entry NameADCYA_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0021724|Adenylate cyclase type 10 (ADCY10)
ATGTTGGTCTTTGGAGATGAAACACACAGCCACTTTCTGGTGATTGGTCAGGCAGTGGAC
GATGTGCGCCTTGCCCAGAACATGGCTCAGATGAATGATGTTATTCTGTCACCAAACTGC
TGGCAGCTCTGTGACCGGAGCATGATTGAAATTGAGAGTGTTCCAGATCAGAGAGCAGTT
AAGGTTAACTTCTTAAAACCACCCCCCAATTTTAATTTTGATGAATTTTTCACAAAGTGT
ACGACCTTCATGCATTATTATCCTTCTGGTGAGCACAAAAACCTCCTGAGGCTTGCATGC
ACGCTGAAGCCTGATCCTGAACTGGAGATGTCCCTACAAAAGTATGTGATGGAAAGCATT
TTGAAGCAGATTGATAACAAACAGCTTCAGGGCTATTTATCTGAGCTTCGCCCAGTGACG
ATTGTGTTTGTGAACCTGATGTTTGAAGACCAAGACAAAGCAGAAGAGATAGGCCCAGCC
ATCCAGGATGCCTATATGCACATCACTTCTGTCCTGAAGATCTTCCAAGGCCAAATCAAT
AAAGTCTTCATGTTTGACAAGGGCTGCTCTTTCCTCTGTGTCTTTGGCTTCCCTGGGGAA
AAGGTACCTGACGAGCTCACTCATGCTCTGGAATGTGCTATGGATATATTTGACTTCTGC
TCTCAAGTCCACAAAATCCAAACTGTATCCATCGGTGTTGCCAGTGGGATTGTCTTCTGT
GGGATCGTTGGACACACTGTGAGACACGAGTACACAGTCATTGGTCAAAAAGTCAACTTA
GCTGCCAGGATGATGATGTACTACCCAGGAATTGTGACCTGCGACTCTGTCACCTACAAT
GGGAGCAACCTACCAGCGTACTTTTTTAAAGAGCTTCCAAAGAAAGTTATGAAAGGTGTT
GCAGATTCTGGACCATTGTATCAGTATTGGGGCCGTACTGAGAAAGTCATGTTTGGTATG
GCGTGCCTCATCTGCAACAGAAAGGAGGATTACCCTTTGCTGGGACGTAATAAAGAGATC
AACTACTTCATGTATACTATGAAGAAATTTTTGATATCTAACAGCAGCCAAGTCTTAATG
TATGAGGGATTACCAGGATATGGAAAAAGCCAGATACTTATGAAAATTGAGTACCTGGCC
CAAGGTAAGAATCACAGGATTATTGCCATTTCATTGAATAAGATCAGCTTCCATCAAACT
TTCTATACCATCCAGATGTTCATGGCCAATGTCCTAGGCCTAGACACTTGTAAACATTAT
AAAGAACGACAGACCAACCTTCGAAATAAAGTCATGACACTGTTGGATGAAAAGTTCTAC
TGTCTTCTTAATGACATTTTCCATGTTCAGTTCCCTATTTCTCGGGAGATTTCCAGGATG
AGCACCTTGAAAAAGCAAAAACAATTGGAAATATTGTTTATGAAGATCTTGAAGCTGATA
GTGAAAGAGGAAAGGATTATTTTTATCATTGATGAGGCCCAGTTTGTGGATTCGACCTCC
TGGAGATTTATGGAGAAGCTTATCCGGACTCTTCCTATCTTCATCATTATGTCCCTGTGT
CCCTTCGTTAACATTCCCTGTGCAGCTGCCAGGGCCGTAATAAAGAACAGGAACACCACC
TACATTGTCATTGGTGCAGTACAGCCTAACGACATCTCCAACAAGATCTGTCTTGACCTC
AATGTGAGCTGCATCTCCAAAGAACTGGACTCGTACCTGGGGGAGGGAAGCTGTGGGATT
CCATTTTACTGTGAAGAATTGCTTAAAAACCTGGAACATCATGAGGTACTCGTTTTCCAA
CAAACGGAGTCTGAGGAAAAGACAAATAGGACCTGGAATAACCTGTTCAAGTATTCCATT
AAGCTAACAGAGAAGTTAAACATGGTTACTCTCCATAGTGATAAGGAAAGTGAAGAAGTC
TGTCACCTCACAAGTGGTGTCAGACTGAAAAACCTGTCACCTCCAACGTCATTAAAAGAA
ATCTCTCTGATCCAGCTGGATAGCATGAGACTTTCCCACCAAATGCTGGTGAGATGTGCT
GCCATCATTGGCCTGACCTTCACCACTGAGTTGTTGTTTGAGATTCTCCCCTGTTGGAAT
ATGAAGATGATGATCAAGACCCTGGCAACCCTAGTGGAATCTAACATTTTTTATTGTTTC
CGGAATGGCAAGGAGCTTCAAAAGGCCCTGAAACAGAATGATCCCTCATTTGAGGTGCAC
TATCGTTCCTTGTCTCTGAAGCCCAGTGAAGGGATGGATCACGGTGAAGAGGAACAGCTT
CGTGAACTGGAGAATGAGGTGATCGAGTGCCACAGGATTCGATTCTGTAACCCTATGATG
CAGAAAACAGCCTACGAGCTGTGGCTCAAGGACCAGAGAAAAGCCATGCACTTGAAATGT
GCCCGCTTTTTAGAAGAAGATGCCCACAGATGTGACCACTGCCGAGGCAGGGACTTCATT
CCCTATCATCACTTCACAGTGAATATTCGGCTCAACGCTTTAGACATGGATGCCATTAAA
AAGATGGCTATGTCTCATGGATTTAAAACTGAAGAAAAGCTTATCTTGTCCAACTCAGAG
ATTCCTGAGACATCTGCATTTTTTCCTGAAAATCGCAGTCCTGAAGAAATAAGAGAAAAG
ATCTTGAATTTCTTTGACCACGTTTTAACAAAAATGAAGACATCTGACGAAGACATTATC
CCTCTGGAATCTTGCCAGTGTGAAGAAATCCTAGAGATTGTCATCTTGCCTCTGGCCCAC
CATTTTCTGGCTTTGGGAGAAAATGACAAAGCCTTATATTACTTCTTAGAAATTGCATCT
GCTTATCTCATCTTTTGTGATAACTACATGGCATACATGTATTTGAATGAAGGACAGAAG
TTGCTAAAAACTCTCAAGAAGGACAAATCTTGGAGCCAGACATTTGAGTCTGCCACCTTT
TACAGCCTCAAAGGTGAGGTCTGTTTCAATATGGGCCAGATAGTGCTTGCCAAGAAAATG
CTGAGGAAGGCACTGAAGCTCCTCAACCGAATCTTTCCTTACAACTTAATCTCCTTGTTT
CTCCATATCCATGTCGAGAAAAACAGACACTTTCATTATGTGAATCGGCAGGCCCAAGAG
AGCCCACCTCCAGGGAAGAAGAGGCTGGCACAACTTTACCGGCAAACTGTCTGCCTTTCC
TTGCTGTGGCGCATCTATAGCTACAGTTATCTTTTTCACTGCAAGTATTATGCCCACCTG
GCAGTTATGATGCAAATGAATACTGCACTGGAAACTCAAAATTGTTTCCAGATCATTAAG
GCTTACCTAGACTATTCGCTATACCACCACCTGGCTGGCTACAAAGGTGTGTGGTTCAAA
TATGAAGTCATGGCCATGGAGCACATCTTCAACCTCCCCCTGAAAGGCGAGGGCATTGAA
ATCGTGGCATACGTGGCTGAGACACTGGTCTTCAACAAGCTCATAATGGGACACCTGGAT
TTGGCCATTGAGTTAGGCTCCCGAGCCCTTCAGATGTGGGCACTGCTCCAGAATCCCAAC
CGACATTATCAGTCCCTCTGCAGACTTAGCAGATGTCTCCTTCTGAACAGCAGATACCCG
CAATTGATCCAGGTGCTGGGGCGGCTGTGGGAGCTTTCTGTAACACAGGAACACATCTTC
AGCAAGGCATTTTTCTATTTTGTCTGCTTGGACATCCTGCTTTATTCTGGTTTTGTTTAT
AGAACATTTGAAGAATGTTTGGAATTCATACACCAATACGAAAACAACAGAATCCTCAAG
TTCCACAGTGGACTCCTCCTGGGACTTTATTCCTCTGTAGCTATCTGGTATGCCAGACTT
CAGGAATGGGACAACTTTTACAAATTTTCCAATAGAGCTAAAAATCTTTTGCCAAGAAGA
ACCATGACACTTACTTACTATGACGGAATATCTAGGTACATGGAGGGGCAAGTTCTTCAC
CTTCAAAAACAAATCAAAGAACAGTCAGAGAATGCCCAAGCCAGTGGGGAGGAGCTACTC
AAGAACTTGGAGAATCTGGTGGCTCAAAATACCACTGGCCCTGTCTTTTGCCCAAGGCTC
TACCACCTGATGGCTTACGTCTGTATATTAATGGGAGATGGGCAGAAATGTGGCCTCTTC
CTGAACACAGCCTTGCGGCTCTCTGAAACACAGGGGAATATACTGGAGAAATGCTGGCTG
AACATGAACAAAGAATCATGGTACTCAACCTCTGAGTTAAAAGAAGACCAATGGCTTCAG
ACGATCTTGAGTCTCCCATCATGGGAAAAAATTGTAGCAGGCAGGGTAAACATTCAGGAT
CTTCAAAAAAACAAATTCCTGATGAGAGCTAATACCGTGGACAATCATTTCTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:21285
Chromosome Location1
LocusNot Available
References
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