Putative gonadotropin-releasing hormone II receptor

NamePutative gonadotropin-releasing hormone II receptor
Synonyms
  • GnRH II receptor
  • Type II GnRH receptor
Gene NameGNRHR2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037024|Putative gonadotropin-releasing hormone II receptor
MSAGNGTPWDATWNITVQWLAVDIACRTLMFLKLMATYSAAFLPVVIGLDRQAAVLNPLG
SRSGVRKLLGAAWGLSFLLAFPQLFLFHTVHCAGPVPFTQCVTKGSFKAQWQETTYNLFT
FCCLFLLPLTAMAICYSRIVLSVSRPQTRKGSHAPAGEFALPRSFDNCPRVRLRALRLAL
LILLTFILCWTPYYLLGMWYWFSPTMLTEVPPSLSHILFLLGLLNAPLDPLLYGAFTLGC
RRGHQELSIDSSKEGSGRMLQEEIHAFRQLEVQKTVTSRRAGETKGISITSI
Number of residues292
Molecular Weight32536.935
Theoretical pI9.68
GO Classification
Functions
  • gonadotropin-releasing hormone receptor activity
Components
  • plasma membrane
  • integral component of membrane
General FunctionGonadotropin-releasing hormone receptor activity
Specific FunctionPutative receptor for gonadotropin releasing hormone II (GnRH II) which is most probably non-functional.
Pfam Domain Function
Transmembrane Regions29-49 68-88 116-136 178-198 217-237
GenBank Protein ID16589056
UniProtKB IDQ96P88
UniProtKB Entry NameGNRR2_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0000942|1140 bp
CATGTCTGCAGGCAACGGCACCCCTTGGGGTCAGCAGCGGGGGAGGAGGTCTGGGCTGGA
TCAGGAGTGGAGGTGGAGGGCTCAGAGCTGCCCACCTTCTCGGCAGCAGCCAAGGTCCGA
GTGGGAGTGACCATTGTGCTGTTTGTTTCTTCGGCTGGAGGGAACCTGGCAGTCCTGTGG
TCAGTGACACGGCGGGAACCCAGCCAGCTCCGCCCCTCTCCGGTCAGGAGACTCTTCATC
CATTTAGCAGCCGCCGACTTACTAGTCACTTTTGTGGTTATGCCCCTAGATGCCACCTGG
AATATCACTGTTCAATGGCTGGCTGTGGACATCGCATGTCGGACACTGATGTTCCTGAAA
CTAATGGCCACGTATTCTGCAGCTTTCCTGCCTGTGGTCATTGGATTGGACCGCCAGGCA
GCAGTACTCAACCCGCTTGGATCCCGTTCAGGTGTAAGGAAACTTCTGGGGGCAGCCTGG
GGACTTAGTTTCCTGCTTGCCTTCCCCCAGCTGTTCCTGTTCCACACGGTCCACTGAGCT
GGCCCAGTCCCTTTCACTCAGTGTGTCACCAAAGGCAGCTTCAAGGCTCAATGGCAAGAG
ACCACCTATAACCTCTTCACCTTCTGCTGCCTCTTTCTGCTGCCACTGACTGCCATGGCC
ATCTGCTATAGCCGCATTGTCCTCAGTGTGTCCAGGCCCCAGACAAGGAAGGGGAGCCAT
GCCCCTGCTGGTGAATTTGCCCTCCCCCGCTCCTTTGACAATTGTCCCCGTGTTCGTCTC
CGGGCCCTGAGACTGGCCCTGCTTATCTTGCTGACCTTCATCCTCTGCTGGACACCTTAT
TACCTACTGGGTATGTGGTACTGGTTCTCCCCCACCATGCTAACTGAAGTCCCTCCCAGC
CTGAGCCACATCCTTTTCCTCTTGGGCCTCCTCAATGCTCCTTTGGATCCTCTCCTCTAT
GGGGCCTTCACCCTTGGCTGCCGAAGAGGGCACCAAGAACTTAGTATAGACTCTTCTAAA
GAAGGGTCTGGGAGAATGCTCCAAGAGGAGATTCATGCCTTTAGACAGCTGGAAGTACAA
AAAACTGTGACATCAAGAAGGGCAGGAGAAACAAAAGGCATTTCTATAACATCTATCTGA
GenBank Gene IDAF403014
GeneCard IDNot Available
GenAtlas IDGNRHR2
HGNC IDHGNC:16341
Chromosome LocationNot Available
Locus1q12
References
  1. Faurholm B, Millar RP, Katz AA: The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci. Genomics. 2001 Nov;78(1-2):15-8. 11707068
  2. Neill JD: GnRH and GnRH receptor genes in the human genome. Endocrinology. 2002 Mar;143(3):737-43. 11861490
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  4. Morgan K, Conklin D, Pawson AJ, Sellar R, Ott TR, Millar RP: A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12. Endocrinology. 2003 Feb;144(2):423-36. 12538601
  5. Stewart AJ, Katz AA, Millar RP, Morgan K: Retention and silencing of prepro-GnRH-II and type II GnRH receptor genes in mammals. Neuroendocrinology. 2009;90(4):416-32. doi: 10.1159/000233303. Epub 2009 Aug 5. 19657181