NameChloride intracellular channel protein 6
Synonyms
  • CLIC1L
  • Parchorin
Gene NameCLIC6
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009051|Chloride intracellular channel protein 6
MAEAAEPEGVAPGPQGPPEVPAPLAERPGEPGAAGGEAEGPEGSEGAEEAPRGAAAVKEA
GGGGPDRGPEAEARGTRGAHGETEAEEGAPEGAEVPQGGEETSGAQQVEGASPGRGAQGE
PRGEAQREPEDSAAPERQEEAEQRPEVPEGSASGEAGDSVDAEGPLGDNIEAEGPAGDSV
EAEGRVGDSVDAEGPAGDSVDAEGPLGDNIQAEGPAGDSVDAEGRVGDSVDAEGPAGDSV
DAEGRVGDSVEAGDPAGDGVEAGVPAGDSVEAEGPAGDSMDAEGPAGRARRVSGEPQQSG
DGSLSPQAEAIEVAAGESAGRSPGELAWDAAEEAEVPGVKGSEEAAPGDARADAGEDRVG
DGPQQEPGEDEERRERSPEGPREEEAAGGEEESPDSSPHGEASRGAAEPEAQLSNHLAEE
GPAEGSGEAARVNGRREDGEASEPRALGQEHDITLFVKVKLTALGCSRIAIKKYLRAGYD
GESIGNCPFSQRLFMILWLKGVIFNVTTVDLKRKPADLQNLAPGTNPPFMTFDGEVKTDV
NKIEEFLEEKLAPPRYPKLGTQHPESNSAGNDVFAKFSAFIKNTKKDANEIHEKNLLKAL
RKLDNYLNSPLPDEIDAYSTEDVTVSGRKFLDGDELTLADCNLLPKLHIIKIVAKKYRDF
EFPSEMTGIWRYLNNAYARDEFTNTCPADQEIEHAYSDVAKRMK
Number of residues704
Molecular Weight73010.875
Theoretical pINot Available
GO Classification
Functions
  • voltage-gated ion channel activity
  • chloride channel activity
Processes
  • chloride transmembrane transport
Components
  • plasma membrane
  • extracellular exosome
  • chloride channel complex
  • cytoplasm
General FunctionVoltage-gated ion channel activity
Specific FunctionMay insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity).
Pfam Domain Function
Transmembrane Regions489-509
GenBank Protein IDNot Available
UniProtKB IDQ96NY7
UniProtKB Entry NameCLIC6_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0017675|Chloride intracellular channel protein 6 (CLIC6)
ATGGCCGAGGCCGCGGAGCCGGAGGGGGTTGCCCCGGGTCCCCAGGGGCCGCCGGAGGTC
CCCGCGCCTCTGGCTGAGAGACCCGGAGAGCCAGGAGCCGCGGGCGGGGAGGCAGAAGGG
CCGGAGGGGAGCGAGGGCGCAGAGGAGGCGCCGAGGGGCGCCGCCGCTGTGAAGGAGGCA
GGAGGCGGCGGGCCAGACAGGGGCCCGGAGGCCGAGGCGCGGGGCACGAGGGGGGCGCAC
GGCGAGACTGAGGCCGAGGAGGGAGCCCCGGAGGGTGCCGAGGTGCCCCAAGGAGGGGAG
GAGACAAGCGGCGCGCAGCAGGTGGAGGGGGCGAGCCCGGGACGCGGCGCGCAGGGCGAG
CCCCGCGGGGAGGCTCAGAGGGAGCCCGAGGACTCTGCGGCCCCCGAGAGGCAGGAGGAG
GCGGAGCAGAGGCCTGAGGTCCCGGAAGGTAGCGCGTCCGGGGAGGCGGGGGACAGCGTA
GACGCGGAGGGCCCGCTGGGGGACAACATAGAAGCGGAGGGCCCGGCGGGCGACAGCGTA
GAGGCGGAGGGCCGGGTGGGGGACAGCGTAGACGCGGAAGGTCCGGCGGGGGACAGCGTA
GACGCGGAGGGCCCGCTGGGGGACAACATACAAGCCGAGGGCCCGGCGGGGGACAGCGTA
GACGCGGAGGGCCGGGTGGGGGACAGCGTAGACGCGGAAGGTCCGGCGGGGGACAGCGTA
GACGCGGAGGGCCGGGTGGGGGACAGCGTAGAGGCGGGGGACCCGGCGGGGGACGGCGTA
GAAGCGGGGGTCCCGGCGGGGGACAGCGTAGAAGCCGAAGGCCCGGCGGGGGACAGCATG
GACGCCGAGGGTCCGGCAGGAAGGGCGCGCCGGGTCTCGGGTGAGCCGCAGCAATCGGGG
GACGGCAGCCTCTCGCCCCAGGCCGAGGCAATTGAGGTCGCAGCCGGGGAGAGTGCGGGG
CGCAGCCCCGGTGAGCTCGCCTGGGACGCAGCGGAGGAGGCGGAGGTCCCGGGGGTAAAG
GGGTCCGAAGAAGCGGCCCCCGGGGACGCAAGGGCAGACGCTGGCGAGGACAGGGTAGGG
GATGGGCCACAGCAGGAGCCGGGGGAGGACGAAGAGAGACGAGAGCGGAGCCCGGAGGGG
CCAAGGGAGGAGGAAGCAGCGGGGGGCGAAGAGGAATCCCCCGACAGCAGCCCACATGGG
GAGGCCTCCAGGGGCGCCGCGGAGCCTGAGGCCCAGCTCAGCAACCACCTGGCCGAGGAG
GGCCCCGCCGAGGGTAGCGGCGAGGCCGCGCGCGTGAACGGCCGCCGGGAGGACGGAGAG
GCGTCCGAGCCCCGGGCCCTGGGGCAGGAGCACGACATCACCCTCTTCGTCAAGGCTGGT
TATGATGGTGAGAGTATCGGAAATTGCCCGTTTTCTCAGCGTCTCTTTATGATTCTCTGG
CTGAAAGGCGTTATATTTAATGTGACCACAGTGGACCTGAAAAGGAAACCCGCAGACCTG
CAGAACCTGGCTCCCGGAACAAACCCTCCTTTCATGACTTTTGATGGTGAAGTCAAGACG
GATGTGAATAAGATCGAGGAGTTCTTAGAGGAGAAATTAGCTCCCCCGAGGTATCCCAAG
CTGGGGACCCAACATCCCGAATCTAATTCCGCAGGAAATGACGTGTTTGCCAAATTCTCA
GCGTTTATAAAAAACACGAAGAAGGATGCAAATGAGATTCATGAAAAGAACCTGCTGAAG
GCCCTGAGGAAGCTGGATAATTACTTAAATAGCCCTCTGCCTGATGAAATAGATGCCTAC
AGCACCGAGGATGTCACTGTTTCTGGAAGGAAGTTTCTGGATGGGGACGAGCTGACGCTG
GCTGACTGCAACCTCTTACCCAAGCTCCATATTATTAAGATTGTGGCCAAGAAGTACAGA
GATTTTGAATTTCCTTCTGAAATGACTGGCATCTGGAGATACTTGAATAATGCTTATGCT
AGAGATGAGTTCACAAATACGTGTCCAGCTGATCAAGAGATTGAACACGCATATTCAGAT
GTTGCAAAAAGAATGAAATGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:2065
Chromosome Location21
LocusNot Available
References
  1. Friedli M, Guipponi M, Bertrand S, Bertrand D, Neerman-Arbez M, Scott HS, Antonarakis SE, Reymond A: Identification of a novel member of the CLIC family, CLIC6, mapping to 21q22.12. Gene. 2003 Nov 27;320:31-40. 14597386
  2. Strippoli P, D'Addabbo P, Lenzi L, Giannone S, Canaider S, Casadei R, Vitale L, Carinci P, Zannotti M: Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q. Mamm Genome. 2002 Aug;13(8):456-62. 12226712
  3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. 14702039
  4. Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML: The DNA sequence of human chromosome 21. Nature. 2000 May 18;405(6784):311-9. 10830953
  5. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334