Proton-coupled folate transporter

NameProton-coupled folate transporter
Synonyms
  • G21
  • HCP1
  • Heme carrier protein 1
  • PCFT
  • PCFT/HCP1
  • Solute carrier family 46 member 1
Gene NameSLC46A1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0002087|Proton-coupled folate transporter
MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGT
RQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLA
SLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFR
MALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKST
RLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWD
SKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFT
GYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNF
MKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP
Number of residues459
Molecular Weight49770.04
Theoretical pI8.97
GO Classification
Functions
  • hydrogen ion transmembrane transporter activity
  • methotrexate transporter activity
  • folic acid binding
  • folic acid transporter activity
Processes
  • cellular iron ion homeostasis
  • folic acid import into cell
  • heme transport
  • intestinal folate absorption
  • small molecule metabolic process
  • methotrexate transport
  • transmembrane transport
  • vitamin metabolic process
  • water-soluble vitamin metabolic process
  • folic acid transport
  • folic acid metabolic process
  • hydrogen ion transmembrane transport
Components
  • cytoplasm
  • plasma membrane
  • cell surface
  • integral component of membrane
  • apical plasma membrane
  • brush border membrane
General FunctionMethotrexate transporter activity
Specific FunctionHas been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme.
Pfam Domain Function
Transmembrane Regions25-48 85-107 114-137 146-168 181-203 213-236 266-288 310-328 332-356 360-381 394-412 425-449
GenBank Protein ID16549261
UniProtKB IDQ96NT5
UniProtKB Entry NamePCFT_HUMAN
Cellular LocationApical cell membrane
Gene sequence
>lcl|BSEQ0016294|Proton-coupled folate transporter (SLC46A1)
ATGGAGGGGAGCGCGAGCCCCCCGGAAAAGCCCCGCGCCCGCCCTGCGGCTGCCGTGCTG
TGCCGGGGCCCGGTAGAGCCGCTGGTCTTCCTGGCCAACTTTGCCTTGGTCCTGCAGGGC
CCGCTCACCACGCAGTATCTGTGGCACCGCTTCAGCGCCGACCTCGGCTACAATGGCACC
CGCCAAAGGGGGGGCTGCAGCAACCGCAGCGCGGACCCCACCATGCAGGAAGTGGAGACC
CTTACCTCCCACTGGACCCTCTACATGAACGTGGGCGGCTTCCTGGTGGGGCTCTTCTCG
TCCACCCTGCTGGGAGCTTGGAGCGACAGTGTGGGCCGCCGCCCGCTGCTAGTGCTGGCC
TCGCTGGGCCTGCTGCTCCAGGCCCTAGTGTCCGTTTTTGTGGTGCAGCTGCAGCTCCAC
GTCGGCTACTTCGTGCTGGGTCGCATCCTTTGTGCCCTCCTCGGCGACTTCGGTGGCCTT
CTGGCTGCTAGCTTTGCGTCCGTGGCAGATGTCAGCTCCAGTCGCAGCCGCACCTTCCGG
ATGGCCCTGCTGGAAGCCAGCATCGGGGTGGCTGGGATGCTGGCAAGCCTCCTCGGGGGC
CACTGGCTCCGGGCCCAGGGTTATGCCAACCCCTTCTGGCTGGCCTTGGCCTTGCTGATA
GCCATGACTCTCTATGCAGCTTTCTGCTTTGGTGAGACCTTAAAGGAGCCAAAGTCCACC
CGGCTCTTCACGTTCCGTCACCACCGATCCATTGTCCAGCTCTATGTGGCTCCCGCCCCA
GAGAAGTCCAGGAAACATTTAGCCCTCTACTCACTGGCCATCTTCGTGGTGATCACTGTG
CACTTTGGGGCCCAGGACATCTTAACCCTTTATGAACTAAGCACACCCCTCTGCTGGGAC
TCCAAACTAATCGGCTATGGTTCTGCAGCTCAGCATCTCCCCTACCTCACCAGCCTGCTG
GCCCTGAAGCTCCTGCAGTACTGCCTGGCCGATGCCTGGGTAGCTGAGATCGGCCTGGCC
TTCAACATCCTGGGGATGGTGGTCTTTGCCTTTGCCACTATCACGCCTCTCATGTTCACA
GGTGCTCTCTTTTCTGCTGTGGCCTGTGTGAATAGCCTGGCCATGCTGACGGCCTCCGGC
ATCTTCAACTCACTCTACCCAGCCACTCTGAACTTTATGAAGGGGTTCCCCTTCCTCCTG
GGAGCTGGCCTCCTGCTCATCCCGGCTGTTCTGATTGGGATGCTGGAAAAGGCTGATCCT
CACCTCGAGTTCCAGCAGTTTCCCCAGAGCCCCTGA
GenBank Gene IDAK054669
GeneCard IDNot Available
GenAtlas IDSLC46A1
HGNC IDHGNC:30521
Chromosome Location17
LocusNot Available
References
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