Lethal(3)malignant brain tumor-like protein 3

NameLethal(3)malignant brain tumor-like protein 3
Synonyms
  • H-l(3)mbt-like protein 3
  • KIAA1798
  • MBT-1
  • MBT1
Gene NameL3MBTL3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009817|Lethal(3)malignant brain tumor-like protein 3
MTESASSTSGQEFDVFSVMDWKDGVGTLPGSDLKFRVNEFGALEVITDENEMENVKKATA
TTTWMVPTAQEAPTSPPSSRPVFPPAYWTSPPGCPTVFSEKTGMPFRLKDPVKVEGLQFC
ENCCQYGNVDECLSGGNYCSQNCARHIKDKDQKEERDVEEDNEEEDPKCSRKKKPKLSLK
ADTKEDGEERDDEMENKQDVRILRGSQRARRKRRGDSAVLKQGLPPKGKKAWCWASYLEE
EKAVAVPAKLFKEHQSFPYNKNGFKVGMKLEGVDPEHQSVYCVLTVAEVCGYRIKLHFDG
YSDCYDFWVNADALDIHPVGWCEKTGHKLHPPKGYKEEEFNWQTYLKTCKAQAAPKSLFE
NQNITVIPSGFRVGMKLEAVDKKNPSFICVATVTDMVDNRFLVHFDNWDESYDYWCEASS
PHIHPVGWCKEHRRTLITPPGYPNVKHFSWDKYLEETNSLPAPARAFKVKPPHGFQKKMK
LEVVDKRNPMFIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPVGWCSKTGHPL
QPPLSPLELMEASEHGGCSTPGCKGIGHFKRARHLGPHSAANCPYSEINLNKDRIFPDRL
SGEMPPASPSFPRNKRTDANESSSSPEIRDQHADDVKEDFEERTESEMRTSHEARGAREE
PTVQQAQRRSAVFLSFKSPIPCLPLRWEQQSKLLPTVAGIPASKVSKWSTDEVSEFIQSL
PGCEEHGKVFKDEQIDGEAFLLMTQTDIVKIMSIKLGPALKIFNSILMFKAAEKNSHNEL
Number of residues780
Molecular Weight88336.035
Theoretical pINot Available
GO Classification
Processes
  • chromatin modification
  • erythrocyte maturation
  • granulocyte differentiation
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • macrophage differentiation
Components
  • nucleus
General FunctionNot Available
Specific FunctionPutative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ96JM7
UniProtKB Entry NameLMBL3_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0021736|Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)
ATGACTGAATCTGCCTCTAGCACAAGTGGTCAAGAGTTTGATGTGTTCAGTGTTATGGAC
TGGAAAGATGGAGTGGGCACGTTACCAGGAAGTGACTTAAAGTTTCGGGTAAATGAGTTT
GGAGCCCTGGAAGTTATTACAGATGAGAATGAGATGGAAAATGTTAAAAAAGCAACTGCT
ACCACCACTTGGATGGTACCAACTGCTCAAGAAGTCTTTTCAGAGAAGACTGGGATGCCT
TTCAGGTTGAAGGATCCAGTGAAAGTAGAAGGGCTTCAGTTCTGTGAGAACTGTTGTCAG
TATGGCAACGTAGATGAGTGTCTTTCTGGAGGAAACTATTGCAGCCAGAATTGTGCTCGG
CACATCAAAGATAAAGATCAGAAGGAAGAAAGGGACGTAGAAGAAGACAATGAGGAAGAA
GATCCTAAGTGTAGTCGGAAGAAAAAACCAAAATTATCTCTGAAAGCTGACACCAAGGAG
GATGGAGAAGAGAGAGATGATGAAATGGAGAACAAACAAGATGTAAGAATCCTGAGGGGT
TCGCAGAGAGCACGGAGGAAAAGACGAGGGGATTCGGCTGTACTAAAGCAGGGTTTGCCT
CCTAAAGGAAAGAAAGCGTGGTGCTGGGCATCCTACCTGGAAGAGGAGAAAGCGGTGGCA
GTGCCGGCGAAGCTGTTCAAGGAGCATCAATCCTTTCCATATAACAAAAATGGATTCAAA
GTTGGCATGAAATTAGAAGGCGTGGATCCTGAGCATCAGTCTGTGTACTGTGTCCTCACC
GTCGCGGAGGTTTGTGGATACCGGATAAAGCTTCACTTTGATGGGTATTCTGATTGCTAT
GACTTCTGGGTGAATGCAGACGCTCTGGATATCCACCCAGTTGGGTGGTGTGAGAAAACC
GGCCACAAACTCCATCCTCCAAAAGGGTATAAAGAAGAAGAATTCAATTGGCAGACCTAT
CTTAAGACATGTAAAGCTCAAGCTGCTCCTAAGTCATTATTTGAAAATCAGAATATAACA
GTGATCCCATCGGGCTTTCGAGTTGGTATGAAGCTTGAGGCAGTAGACAAAAAGAATCCC
TCATTCATCTGTGTTGCTACGGTAACAGATATGGTGGACAATCGTTTCCTGGTACATTTT
GACAACTGGGATGAGAGCTATGACTATTGGTGTGAAGCATCAAGTCCACATATTCATCCA
GTTGGTTGGTGTAAGGAACATAGAAGAACCCTTATTACTCCACCAGGTTATCCAAATGTG
AAACATTTTTCTTGGGATAAATACTTAGAAGAAACCAATTCTTTACCTGCTCCTGCAAGA
GCTTTCAAAGTGAAACCTCCTCATGGATTCCAGAAAAAAATGAAGCTTGAGGTTGTAGAC
AAAAGGAACCCTATGTTTATTAGAGTAGCAACTGTGGCAGACACAGATGATCACCGGGTA
AAAGTTCACTTTGATGGCTGGAACAATTGCTATGATTACTGGATAGATGCAGATTCTCCT
GATATTCACCCTGTAGGCTGGTGTTCAAAAACAGGACATCCCCTTCAGCCTCCTTTGAGC
CCCTTAGAATTAATGGAAGCTTCAGAACATGGTGGATGCTCAACCCCGGGATGTAAAGGG
ATTGGCCATTTCAAGAGAGCGAGACATCTGGGCCCTCACAGTGCTGCCAACTGTCCCTAT
TCAGAAATCAATTTGAATAAAGACCGTATTTTTCCAGACCGCTTAAGTGGTGAGATGCCT
CCGGCTAGTCCGTCATTTCCAAGAAATAAAAGGACAGATGCAAATGAAAGCTCTTCTTCC
CCTGAAATCAGAGACCAGCATGCTGATGATGTCAAAGAAGACTTTGAAGAGAGAACAGAA
AGTGAAATGAGAACATCACATGAAGCCAGAGGTGCCCGGGAAGAACCCACCGTCCAGCAG
GCACAGCGTCGGTCAGCTGTCTTTCTGTCCTTTAAGTCCCCAATTCCATGTCTGCCCTTG
CGCTGGGAGCAGCAAAGCAAACTTCTTCCAACTGTCGCAGGAATCCCTGCCAGTAAAGTT
TCCAAATGGAGCACAGACGAGGTGTCAGAATTTATACAGAGCTTACCTGGGTGTGAAGAA
CATGGAAAGGTATTTAAAGATGAACAAATTGATGGAGAAGCATTTCTACTTATGACTCAA
ACAGACATTGTTAAAATTATGAGCATTAAACTGGGCCCTGCTCTCAAAATTTTCAATTCC
ATCCTGATGTTCAAAGCTGCAGAGAAGAATTCTCACAATGAACTTTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:23035
Chromosome Location6
LocusNot Available
References
  1. Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O: Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 2001 Apr 27;8(2):85-95. 11347906
  2. Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S: The DNA sequence and analysis of human chromosome 6. Nature. 2003 Oct 23;425(6960):805-11. 14574404
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334
  4. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. 17081983
  5. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. 19690332
  6. Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475. 20068231
  7. Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal. 2011 Mar 15;4(164):rs3. doi: 10.1126/scisignal.2001570. 21406692
  8. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. 24275569