NameProtein phosphatase 1 regulatory subunit 14B
Synonyms
  • Phospholipase C-beta-3 neighbouring gene protein
  • PLCB3N
  • PNG
Gene NamePPP1R14B
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013624|Protein phosphatase 1 regulatory subunit 14B
MADSGTAGGAALAAPAPGPGSGGPGPRVYFQSPPGAAGEGPGGADDEGPVRRQGKVTVKY
DRKELRKRLNLEEWILEQLTRLYDCQEEEIPELEIDVDELLDMESDDARAARVKELLVDC
YKPTEAFISGLLDKIRGMQKLSTPQKK
Number of residues147
Molecular Weight15910.78
Theoretical pINot Available
GO Classification
Functions
  • protein phosphatase inhibitor activity
Processes
  • regulation of phosphorylation
Components
  • cytoplasm
General FunctionProtein phosphatase inhibitor activity
Specific FunctionInhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ96C90
UniProtKB Entry NamePP14B_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0013625|Protein phosphatase 1 regulatory subunit 14B (PPP1R14B)
ATGGCGGACAGCGGCACCGCGGGGGGCGCGGCGTTGGCGGCCCCGGCCCCCGGGCCGGGC
AGTGGCGGCCCAGGACCACGCGTCTACTTTCAGAGCCCCCCCGGGGCCGCAGGAGAGGGC
CCGGGCGGGGCGGACGATGAGGGCCCAGTGAGGCGCCAAGGGAAGGTCACCGTCAAGTAT
GACCGCAAGGAGCTACGGAAGCGCCTCAACCTAGAGGAGTGGATCCTGGAGCAGCTCACG
CGCCTCTACGACTGCCAGGAAGAGGAGATCCCAGAACTGGAGATTGACGTGGATGAGCTC
CTGGACATGGAGAGTGACGATGCCCGGGCTGCCAGGGTCAAGGAGCTGCTGGTTGACTGT
TACAAACCCACAGAGGCCTTCATTTCTGGCCTGCTGGACAAGATCCGGGGCATGCAGAAG
CTGAGCACACCCCAGAAGAAGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9057
Chromosome Location11
LocusNot Available
References
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  2. Lagercrantz J, Carson E, Larsson C, Nordenskjold M, Weber G: Isolation and characterization of a novel gene close to the human phosphoinositide-specific phospholipase C beta 3 gene on chromosomal region 11q13. Genomics. 1996 Feb 1;31(3):380-4. 8838322
  3. Beausoleil SA, Villen J, Gerber SA, Rush J, Gygi SP: A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat Biotechnol. 2006 Oct;24(10):1285-92. Epub 2006 Sep 10. 16964243
  4. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. 18669648
  5. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. 19413330
  6. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. 19690332
  7. Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475. 20068231
  8. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. 21269460
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