Pyrroline-5-carboxylate reductase 2

NamePyrroline-5-carboxylate reductase 2
Synonyms
  • 1.5.1.2
  • P5C reductase 2
Gene NamePYCR2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0018998|Pyrroline-5-carboxylate reductase 2
MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGVNLTRSNKETV
KHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMAFQPAPKVIRC
MTNTPVVVQEGATVYATGTHALVEDGQLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAY
AFMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIH
ALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKISPAALKKTLLDRVKLESPTVSTL
TPSSPGKLLTRSLALGGKKD
Number of residues320
Molecular Weight33636.815
Theoretical pI7.87
GO Classification
Functions
  • pyrroline-5-carboxylate reductase activity
Processes
  • cellular amino acid biosynthetic process
  • cellular nitrogen compound metabolic process
  • small molecule metabolic process
  • cellular response to oxidative stress
  • L-proline biosynthetic process
Components
  • mitochondrion
  • mitochondrial matrix
General FunctionPyrroline-5-carboxylate reductase activity
Specific FunctionHousekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (PubMed:2722838, PubMed:6894153). Involved in cellular response to oxidative stress (PubMed:25865492).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID33150582
UniProtKB IDQ96C36
UniProtKB Entry NameP5CR2_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0018999|Pyrroline-5-carboxylate reductase 2 (PYCR2)
ATGAGCGTGGGCTTCATCGGGGCCGGCCAGCTGGCCTATGCTCTGGCGCGGGGCTTCACG
GCCGCAGGCATCCTGTCGGCTCACAAGATAATAGCCAGCTCCCCAGAAATGAACCTGCCC
ACGGTGTCCGCGCTCAGGAAGATGGGTGTGAACCTGACACGCAGCAACAAGGAGACGGTG
AAGCACAGCGACGTCCTGTTTCTGGCTGTGAAGCCACATATCATCCCCTTCATCCTGGAT
GAGATTGGGGCCGACGTGCAAGCCAGACACATCGTGGTCTCCTGTGCGGCTGGTGTCACC
ATCAGCTCTGTGGAGAAGGCATTCATGGCTCTGGACGCATTGGCTGATGGTGGGGTGAAG
ATGGGTTTGCCACGGCGCCTGGCAATCCAACTCGGGGCCCAGGCTTTGCTGGGAGCTGCC
AAGATGCTGCTGGACTCGGAGCAGCATCCATGCCAGCTTAAGGACAATGTCTGCTCCCCT
GGGGGAGCCACCATCCACGCCCTGCACTTTCTAGAGAGTGGGGGCTTCCGCTCTCTGCTC
ATCAATGCAGTTGAGGCCTCCTGTATCCGAACACGAGAGCTACAGTCCATGGCCGACCAA
GAAAAGATCTCCCCAGCTGCCCTTAAGAAGACCCTCTTAGACAGAGTGAAGCTGGAATCC
CCCACAGTCTCCACACTGACCCCCTCCAGCCCAGGGAAGCTCCTCACAAGAAGCCTGGCC
CTGGGAGGCAAGAAGGACTAA
GenBank Gene IDAF087859
GeneCard IDNot Available
GenAtlas IDPYCR2
HGNC IDHGNC:30262
Chromosome Location1
Locus1q42.12
References
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