NameBcl2-associated agonist of cell death
Synonyms
  • BAD
  • BBC6
  • Bcl-2-binding component 6
  • Bcl-2-like protein 8
  • Bcl-xL/Bcl-2-associated death promoter
  • Bcl2 antagonist of cell death
  • Bcl2-L-8
  • BCL2L8
Gene NameBAD
OrganismHuman
Amino acid sequence
>lcl|BSEQ0006675|Bcl2-associated agonist of cell death
MFQIPEFEPSEQEDSSSAERGLGPSPAGDGPSGSGKHHRQAPGLLWDASHQQEQPTSSSH
HGGAGAVEIRSRHSSYPAGTEDDEGMGEEPSPFRGRSRSAPPNLWAAQRYGRELRRMSDE
FVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSAPSQ
Number of residues168
Molecular Weight18391.765
Theoretical pI7.19
GO Classification
Functions
  • cysteine-type endopeptidase activator activity involved in apoptotic process
  • lipid binding
  • phospholipid binding
  • protein kinase binding
Processes
  • positive regulation of type B pancreatic cell development
  • cellular response to mechanical stimulus
  • extrinsic apoptotic signaling pathway in absence of ligand
  • positive regulation of glucokinase activity
  • activation of cysteine-type endopeptidase activity involved in apoptotic process
  • response to oleic acid
  • response to estradiol
  • negative regulation of cytolysis
  • intrinsic apoptotic signaling pathway
  • response to hydrogen peroxide
  • positive regulation of neuron death
  • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  • apoptotic process
  • positive regulation of insulin secretion involved in cellular response to glucose stimulus
  • response to drug
  • ATP metabolic process
  • fibroblast growth factor receptor signaling pathway
  • neurotrophin TRK receptor signaling pathway
  • positive regulation of apoptotic process by virus
  • positive regulation of proteolysis
  • response to glucose
  • response to calcium ion
  • positive regulation of B cell differentiation
  • positive regulation of intrinsic apoptotic signaling pathway
  • programmed cell death
  • positive regulation of release of cytochrome c from mitochondria
  • response to glucocorticoid
  • positive regulation of T cell differentiation
  • suppression by virus of host apoptotic process
  • positive regulation of insulin secretion
  • cytokine-mediated signaling pathway
  • extrinsic apoptotic signaling pathway via death domain receptors
  • pore complex assembly
  • response to progesterone
  • ADP metabolic process
  • activation of cysteine-type endopeptidase activity
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
  • positive regulation of epithelial cell proliferation
  • cellular response to lipid
  • glucose homeostasis
  • positive regulation of autophagy
  • phosphatidylinositol-mediated signaling
  • regulation of mitochondrial membrane permeability
  • epidermal growth factor receptor signaling pathway
  • cellular response to nicotine
  • cellular response to hypoxia
  • cellular process regulating host cell cycle in response to virus
  • innate immune response
  • response to testosterone
  • response to amino acid
  • positive regulation of mitochondrial membrane potential
  • intrinsic apoptotic signaling pathway in response to DNA damage
  • extrinsic apoptotic signaling pathway
  • response to ethanol
  • glucose catabolic process
  • positive regulation of apoptotic process
  • type B pancreatic cell proliferation
  • apoptotic signaling pathway
  • cellular response to chromate
  • Fc-epsilon receptor signaling pathway
  • release of cytochrome c from mitochondria
Components
  • mitochondrion
  • mitochondrial outer membrane
  • cytosol
General FunctionProtein kinase binding
Specific FunctionPromotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ92934
UniProtKB Entry NameBAD_HUMAN
Cellular LocationMitochondrion outer membrane
Gene sequence
>lcl|BSEQ0021355|Bcl2-associated agonist of cell death (BAD)
ATGTTCCAGATCCCAGAGTTTGAGCCGAGTGAGCAGGAAGACTCCAGCTCTGCAGAGAGG
GGCCTGGGCCCCAGCCCCGCAGGGGACGGGCCCTCAGGCTCCGGCAAGCATCATCGCCAG
GCCCCAGGCCTCCTGTGGGACGCCAGTCACCAGCAGGAGCAGCCAACCAGCAGCAGCCAT
CATGGAGGCGCTGGGGCTGTGGAGATCCGGAGTCGCCACAGCTCCTACCCCGCGGGGACG
GAGGACGACGAAGGGATGGGGGAGGAGCCCAGCCCCTTTCGGGGCCGCTCGCGCTCGGCG
CCCCCCAACCTCTGGGCAGCACAGCGCTATGGCCGCGAGCTCCGGAGGATGAGTGACGAG
TTTGTGGACTCCTTTAAGAAGGGACTTCCTCGCCCGAAGAGCGCGGGCACAGCAACGCAG
ATGCGGCAAAGCTCCAGCTGGACGCGAGTCTTCCAGTCCTGGTGGGATCGGAACTTGGGC
AGGGGAAGCTCCGCCCCCTCCCAGTGA
GenBank Gene IDU66879
GeneCard IDNot Available
GenAtlas IDBAD
HGNC IDHGNC:936
Chromosome Location11
Locus11q13.1
References
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