NameBcl-2-like protein 2
Synonyms
  • Apoptosis regulator Bcl-W
  • Bcl2-L-2
  • BCLW
  • KIAA0271
Gene NameBCL2L2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037235|Bcl-2-like protein 2
MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRT
FSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVG
QVQEWMVAYLETQLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVAL
GALVTVGAFFASK
Number of residues193
Molecular Weight20746.24
Theoretical pI5.27
GO Classification
Functions
  • protein heterodimerization activity
  • protein homodimerization activity
Processes
  • negative regulation of apoptotic process
  • negative regulation of intrinsic apoptotic signaling pathway
  • spermatogenesis
  • extrinsic apoptotic signaling pathway in absence of ligand
  • Sertoli cell proliferation
  • intrinsic apoptotic signaling pathway in response to DNA damage
Components
  • mitochondrial outer membrane
  • cytosol
  • extracellular exosome
General FunctionProtein homodimerization activity
Specific FunctionPromotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ92843
UniProtKB Entry NameB2CL2_HUMAN
Cellular LocationMitochondrion membrane
Gene sequence
>lcl|BSEQ0012395|Bcl-2-like protein 2 (BCL2L2)
ATGGCGACCCCAGCCTCGGCCCCAGACACACGGGCTCTGGTGGCAGACTTTGTAGGTTAT
AAGCTGAGGCAGAAGGGTTATGTCTGTGGAGCTGGCCCCGGGGAGGGCCCAGCAGCTGAC
CCGCTGCACCAAGCCATGCGGGCAGCTGGAGATGAGTTCGAGACCCGCTTCCGGCGCACC
TTCTCTGATCTGGCGGCTCAGCTGCATGTGACCCCAGGCTCAGCCCAACAACGCTTCACC
CAGGTCTCCGATGAACTTTTTCAAGGGGGCCCCAACTGGGGCCGCCTTGTAGCCTTCTTT
GTCTTTGGGGCTGCACTGTGTGCTGAGAGTGTCAACAAGGAGATGGAACCACTGGTGGGA
CAAGTGCAGGAGTGGATGGTGGCCTACCTGGAGACGCGGCTGGCTGACTGGATCCACAGC
AGTGGGGGCTGGGCGGAGTTCACAGCTCTATACGGGGACGGGGCCCTGGAGGAGGCGCGG
CGTCTGCGGGAGGGGAACTGGGCATCAGTGAGGACAGTGCTGACGGGGGCCGTGGCACTG
GGGGCCCTGGTAACTGTAGGGGCCTTTTTTGCTAGCAAGTGA
GenBank Gene IDU59747
GeneCard IDNot Available
GenAtlas IDBCL2L2
HGNC IDHGNC:995
Chromosome Location14
Locus14q11.2-q12
References
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