Histone deacetylase 2

NameHistone deacetylase 2
Synonyms
  • 3.5.1.98
  • HD2
Gene NameHDAC2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004647|Histone deacetylase 2
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
Number of residues488
Molecular Weight55363.855
Theoretical pI5.75
GO Classification
Functions
  • deacetylase activity
  • NAD-dependent histone deacetylase activity (H3-K14 specific)
  • enzyme binding
  • NF-kappaB binding
  • sequence-specific DNA binding
  • protein deacetylase activity
  • RNA polymerase II repressing transcription factor binding
  • poly(A) RNA binding
  • chromatin binding
  • core promoter binding
  • transcription factor binding
  • histone deacetylase activity
Processes
  • positive regulation of tumor necrosis factor production
  • histone deacetylation
  • behavioral response to ethanol
  • dendrite development
  • response to amphetamine
  • negative regulation of cell cycle
  • maintenance of chromatin silencing
  • response to lipopolysaccharide
  • circadian regulation of gene expression
  • negative regulation of peptidyl-lysine acetylation
  • negative regulation of transcription from RNA polymerase II promoter
  • gene expression
  • negative regulation of gene expression, epigenetic
  • negative regulation of dendritic spine development
  • response to cocaine
  • regulation of gene expression, epigenetic
  • positive regulation of interleukin-1 production
  • positive regulation of oligodendrocyte differentiation
  • ATP-dependent chromatin remodeling
  • cellular response to dopamine
  • cellular response to heat
  • odontogenesis of dentin-containing tooth
  • chromatin remodeling
  • cellular response to retinoic acid
  • embryonic digit morphogenesis
  • transcription, DNA-templated
  • epidermal cell differentiation
  • cellular response to transforming growth factor beta stimulus
  • fungiform papilla formation
  • cellular response to hydrogen peroxide
  • eyelid development in camera-type eye
  • positive regulation of epithelial to mesenchymal transition
  • hair follicle placode formation
  • histone H3 deacetylation
  • positive regulation of transcription, DNA-templated
  • cardiac muscle hypertrophy
  • blood coagulation
  • response to nicotine
  • histone H4 deacetylation
  • response to hyperoxia
  • negative regulation of MHC class II biosynthetic process
  • chromatin organization
  • positive regulation of receptor biosynthetic process
  • negative regulation of apoptotic process
  • response to drug
  • response to caffeine
  • positive regulation of proteolysis
  • neurotrophin TRK receptor signaling pathway
  • negative regulation of sequence-specific DNA binding transcription factor activity
  • negative regulation of neuron projection development
  • positive regulation of transcription from RNA polymerase II promoter
  • negative regulation of transcription, DNA-templated
  • negative regulation of DNA binding
  • positive regulation of cell proliferation
  • positive regulation of collagen biosynthetic process
  • positive regulation of tyrosine phosphorylation of Stat3 protein
Components
  • nucleoplasm
  • cytoplasm
  • protein complex
  • nuclear chromatin
  • nucleus
  • NuRD complex
  • Sin3 complex
  • ESC/E(Z) complex
General FunctionTranscription factor binding
Specific FunctionResponsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID1667394
UniProtKB IDQ92769
UniProtKB Entry NameHDAC2_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0016767|Histone deacetylase 2 (HDAC2)
ATGGCGTACAGTCAAGGAGGCGGCAAAAAAAAAGTCTGCTACTACTACGACGGTGATATT
GGAAATTATTATTATGGACAGGGTCATCCCATGAAGCCTCATAGAATCCGCATGACCCAT
AACTTGCTGTTAAATTATGGCTTATACAGAAAAATGGAAATATATAGGCCCCATAAAGCC
ACTGCCGAAGAAATGACAAAATATCACAGTGATGAGTATATCAAATTTCTACGGTCAATA
AGACCAGATAACATGTCTGAGTATAGTAAGCAGATGCAGAGATTTAATGTTGGAGAAGAT
TGTCCAGTGTTTGATGGACTCTTTGAGTTTTGTCAGCTCTCAACTGGCGGTTCAGTTGCT
GGAGCTGTGAAGTTAAACCGACAACAGACTGATATGGCTGTTAATTGGGCTGGAGGATTA
CATCATGCTAAGAAATCAGAAGCATCAGGATTCTGTTACGTTAATGATATTGTGCTTGCC
ATCCTTGAATTACTAAAGTATCATCAGAGAGTCTTATATATTGATATAGATATTCATCAT
GGTGATGGTGTTGAAGAAGCTTTTTATACAACAGATCGTGTAATGACGGTATCATTCCAT
AAATATGGGGAATACTTTCCTGGCACAGGAGACTTGAGGGATATTGGTGCTGGAAAAGGC
AAATACTATGCTGTCAATTTTCCAATGAGAGATGGTATAGATGATGAGTCATATGGGCAG
ATATTTAAGCCTATTATCTCAAAGGTGATGGAGATGTATCAACCTAGTGCTGTGGTATTA
CAGTGTGGTGCAGACTCATTATCTGGTGATAGACTGGGTTGTTTCAATCTAACAGTCAAA
GGTCATGCTAAATGTGTAGAAGTTGTAAAAACTTTTAACTTACCATTACTGATGCTTGGA
GGAGGTGGCTACACAATCCGTAATGTTGCTCGATGTTGGACATATGAGACTGCAGTTGCC
CTTGATTGTGAGATTCCCAATGAGTTGCCATATAATGATTACTTTGAGTATTTTGGACCA
GACTTCAAACTGCATATTAGTCCTTCAAACATGACAAACCAGAACACTCCAGAATATATG
GAAAAGATAAAACAGCGTTTGTTTGAAAATTTGCGCATGTTACCTCATGCACCTGGTGTC
CAGATGCAAGCTATTCCAGAAGATGCTGTTCATGAAGACAGTGGAGATGAAGATGGAGAA
GATCCAGACAAGAGAATTTCTATTCGAGCATCAGACAAGCGGATAGCTTGTGATGAAGAA
TTCTCAGATTCTGAGGATGAAGGAGAAGGAGGTCGAAGAAATGTGGCTGATCATAAGAAA
GGAGCAAAGAAAGCTAGAATTGAAGAAGATAAGAAAGAAACAGAGGACAAAAAAACAGAC
GTTAAGGAAGAAGATAAATCCAAGGACAACAGTGGTGAAAAAACAGATACCAAAGGAACC
AAATCAGAACAGCTCAGCAACCCCTGA
GenBank Gene IDU31814
GeneCard IDNot Available
GenAtlas IDHDAC2
HGNC IDHGNC:4853
Chromosome Location6
Locus6q21
References
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