Histone-lysine N-methyltransferase SETD7

NameHistone-lysine N-methyltransferase SETD7
Synonyms
  • 2.1.1.43
  • H3-K4-HMTase SETD7
  • Histone H3-K4 methyltransferase SETD7
  • KIAA1717
  • KMT7
  • Lysine N-methyltransferase 7
  • SET domain-containing protein 7
  • SET7
  • SET7/9
  • SET9
Gene NameSETD7
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004957|Histone-lysine N-methyltransferase SETD7
MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLE
GYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCW
IYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRP
HFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNT
VMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFT
PNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVELKAF
QATQQK
Number of residues366
Molecular Weight40720.595
Theoretical pI4.25
GO Classification
Functions
  • p53 binding
  • histone-lysine N-methyltransferase activity
  • protein-lysine N-methyltransferase activity
  • chromatin binding
Processes
  • cellular response to DNA damage stimulus
  • positive regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • response to ethanol
  • chromatin modification
  • chromatin organization
  • heterochromatin organization
  • peptidyl-lysine dimethylation
  • peptidyl-lysine monomethylation
  • regulation of histone H3-K9 methylation
Components
  • nucleolus
  • nucleoplasm
  • chromosome
General FunctionProtein-lysine n-methyltransferase activity
Specific FunctionHistone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ8WTS6
UniProtKB Entry NameSETD7_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0011800|Histone-lysine N-methyltransferase SETD7 (SETD7)
ATGGATAGCGACGACGAGATGGTGGAGGAGGCGGTGGAAGGGCACCTGGACGATGACGGA
TTACCGCACGGGTTCTGCACAGTCACCTACTCCTCCACAGACAGATTTGAGGGGAACTTT
GTTCACGGAGAAAAGAACGGACGGGGGAAGTTCTTCTTCTTTGATGGCAGCACCCTGGAG
GGGTATTATGTGGATGATGCCTTGCAGGGCCAGGGAGTTTACACTTACGAAGATGGGGGA
GTTCTCCAGGGCACGTATGTAGACGGAGAGCTGAACGGTCCAGCCCAGGAATATGACACA
GATGGGAGACTGATCTTCAAGGGGCAGTATAAAGATAACATTCGTCATGGAGTGTGCTGG
ATATATTACCCAGATGGAGGAAGCCTTGTAGGAGAAGTAAATGAAGATGGGGAGATGACT
GGAGAGAAGATAGCCTATGTGTACCCTGATGAGAGGACCGCACTTTATGGGAAATTTATT
GATGGAGAGATGATAGAAGGCAAACTGGCTACCCTTATGTCCACTGAAGAAGGGAGGCCT
CACTTTGAACTGATGCCTGGAAATTCAGTGTACCACTTTGATAAGTCGACTTCATCTTGC
ATTTCTACCAATGCTCTTCTTCCAGATCCTTATGAATCAGAAAGGGTTTATGTTGCTGAA
TCTCTTATTTCCAGTGCTGGAGAAGGACTTTTTTCAAAGGTAGCTGTGGGACCTAATACT
GTTATGTCTTTTTATAATGGAGTTCGAATTACACACCAAGAGGTTGACAGCAGGGACTGG
GCCCTTAATGGGAACACCCTCTCCCTTGATGAAGAAACGGTCATTGATGTGCCTGAGCCC
TATAACCACGTATCCAAGTACTGTGCCTCCTTGGGACACAAGGCAAATCACTCCTTCACT
CCAAACTGCATCTACGATATTGGCCAGAAGAATCACCTGGGAACGTGTAAAAGAAGCAGA
TTTGGGGCTCCACTCCCAAAGATCCCACATCTGGATCAAGCGCCCTGGGTAGAACACAGA
AAAGCTGGCATTCCTCTTTATAGTGCAGCCCAAGGACTGATGCTCATAATGATGTTCGTG
AGTAATTAA
GenBank Gene IDAF448510
GeneCard IDNot Available
GenAtlas IDSETD7
HGNC IDHGNC:30412
Chromosome Location4
Locus4q28
References
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