T3DB: Methylcytosine dioxygenase TET1

Name	Methylcytosine dioxygenase TET1
Synonyms	1.14.11.n2 CXXC-type zinc finger protein 6 CXXC6 KIAA1676 LCX Leukemia-associated protein with a CXXC domain Ten-eleven translocation 1 gene protein
Gene Name	TET1
Organism	Human
Amino acid sequence	>lcl\|BSEQ0038056\|Methylcytosine dioxygenase TET1 MSRSRHARPSRLVRKEDVNKKKKNSQLRKTTKGANKNVASVKTLSPGKLKQLIQERDVKK KTEPKPPVPVRSLLTRAGAARMNLDRTEVLFQNPESLTCNGFTMALRSTSLSRRLSQPPL VVAKSKKVPLSKGLEKQHDCDYKILPALGVKHSENDSVPMQDTQVLPDIETLIGVQNPSL LKGKSQETTQFWSQRVEDSKINIPTHSGPAAEILPGPLEGTRCGEGLFSEETLNDTSGSP KMFAQDTVCAPFPQRATPKVTSQGNPSIQLEELGSRVESLKLSDSYLDPIKSEHDCYPTS SLNKVIPDLNLRNCLALGGSTSPTSVIKFLLAGSKQATLGAKPDHQEAFEATANQQEVSD TTSFLGQAFGAIPHQWELPGADPVHGEALGETPDLPEIPGAIPVQGEVFGTILDQQETLG MSGSVVPDLPVFLPVPPNPIATFNAPSKWPEPQSTVSYGLAVQGAIQILPLGSGHTPQSS SNSEKNSLPPVMAISNVENEKQVHISFLPANTQGFPLAPERGLFHASLGIAQLSQAGPSK SDRGSSQVSVTSTVHVVNTTVVTMPVPMVSTSSSSYTTLLPTLEKKKRKRCGVCEPCQQK TNCGECTYCKNRKNSHQICKKRKCEELKKKPSVVVPLEVIKENKRPQREKKPKVLKADFD NKPVNGPKSESMDYSRCGHGEEQKLELNPHTVENVTKNEDSMTGIEVEKWTQNKKSQLTD HVKGDFSANVPEAEKSKNSEVDKKRTKSPKLFVQTVRNGIKHVHCLPAETNVSFKKFNIE EFGKTLENNSYKFLKDTANHKNAMSSVATDMSCDHLKGRSNVLVFQQPGFNCSSIPHSSH SIINHHASIHNEGDQPKTPENIPSKEPKDGSPVQPSLLSLMKDRRLTLEQVVAIEALTQL SEAPSENSSPSKSEKDEESEQRTASLLNSCKAILYTVRKDLQDPNLQGEPPKLNHCPSLE KQSSCNTVVFNGQTTTLSNSHINSATNQASTKSHEYSKVTNSLSLFIPKSNSSKIDTNKS IAQGIITLDNCSNDLHQLPPRNNEVEYCNQLLDSSKKLDSDDLSCQDATHTQIEEDVATQ LTQLASIIKINYIKPEDKKVESTPTSLVTCNVQQKYNQEKGTIQQKPPSSVHNNHGSSLT KQKNPTQKKTKSTPSRDRRKKKPTVVSYQENDRQKWEKLSYMYGTICDIWIASKFQNFGQ FCPHDFPTVFGKISSSTKIWKPLAQTRSIMQPKTVFPPLTQIKLQRYPESAEEKVKVEPL DSLSLFHLKTESNGKAFTDKAYNSQVQLTVNANQKAHPLTQPSSPPNQCANVMAGDDQIR FQQVVKEQLMHQRLPTLPGISHETPLPESALTLRNVNVVCSGGITVVSTKSEEEVCSSSF GTSEFSTVDSAQKNFNDYAMNFFTNPTKNLVSITKDSELPTCSCLDRVIQKDKGPYYTHL GAGPSVAAVREIMENRYGQKGNAIRIEIVVYTGKEGKSSHGCPIAKWVLRRSSDEEKVLC LVRQRTGHHCPTAVMVVLIMVWDGIPLPMADRLYTELTENLKSYNGHPTDRRCTLNENRT CTCQGIDPETCGASFSFGCSWSMYFNGCKFGRSPSPRRFRIDPSSPLHEKNLEDNLQSLA TRLAPIYKQYAPVAYQNQVEYENVARECRLGSKEGRPFSGVTACLDFCAHPHRDIHNMNN GSTVVCTLTREDNRSLGVIPQDEQLHVLPLYKLSDTDEFGSKEGMEAKIKSGAIEVLAPR RKKRTCFTQPVPRSGKKRAAMMTEVLAHKIRAVEKKPIPRIKRKNNSTTTNNSKPSSLPT LGSNTETVQPEVKSETEPHFILKSSDNTKTYSLMPSAPHPVKEASPGFSWSPKTASATPA PLKNDATASCGFSERSSTPHCTMPSGRLSGANAAAADGPGISQLGEVAPLPTLSAPVMEP LINSEPSTGVTEPLTPHQPNHQPSFLTSPQDLASSPMEEDEQHSEADEPPSDEPLSDDPL SPAEEKLPHIDEYWSDSEHIFLDANIGGVAIAPAHGSVLIECARRELHATTPVEHPNRNH PTRLSLVFYQHKNLNKPQHGFELNKIKFEAKEAKNKKMKASEQKDQAANEGPEQSSEVNE LNQIPSHKALTLTHDNVVTVSPYALTHVAGPYNHWV
Number of residues	2136
Molecular Weight	235306.965
Theoretical pI	Not Available
GO Classification	Functions methylcytosine dioxygenase activity iron ion binding zinc ion binding structure-specific DNA binding Processes transcription, DNA-templated stem cell population maintenance protein O-linked glycosylation chromatin modification regulation of gene expression, epigenetic regulation of genetic imprinting DNA demethylation regulation of DNA methylation inner cell mass cell differentiation negative regulation of methylation-dependent chromatin silencing oxidative DNA demethylation gene expression positive regulation of transcription from RNA polymerase II promoter Components nucleus
General Function	Zinc ion binding
Specific Function	Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, plays a more general role in chromatin regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and Polycomb-repressed genes. Involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Also involved in transcription repression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification.
Pfam Domain Function	zf-CXXC (PF02008 ) Tet_JBP (PF12851 )
Transmembrane Regions	Not Available
GenBank Protein ID	Not Available
UniProtKB ID	Q8NFU7
UniProtKB Entry Name	TET1_HUMAN
Cellular Location	Nucleus
Gene sequence	>lcl\|BSEQ0013961\|Methylcytosine dioxygenase TET1 (TET1) ATGTCTCGATCCCGCCATGCAAGGCCTTCCAGATTAGTCAGGAAGGAAGATGTAAACAAA AAAAAGAAAAACAGCCAACTACGAAAGACAACCAAGGGAGCCAACAAAAATGTGGCATCA GTCAAGACTTTAAGCCCTGGAAAATTAAAGCAATTAATTCAAGAAAGAGATGTTAAGAAA AAAACAGAACCTAAACCACCCGTGCCAGTCAGAAGCCTTCTGACAAGAGCTGGAGCAGCA CGCATGAATTTGGATAGGACTGAGGTTCTTTTTCAGAACCCAGAGTCCTTAACCTGCAAT GGGTTTACAATGGCGCTACGAAGCACCTCTCTTAGCAGGCGACTCTCCCAACCCCCACTG GTCGTAGCCAAATCCAAAAAGGTTCCACTTTCTAAGGGTTTAGAAAAGCAACATGATTGT GATTATAAGATACTCCCTGCTTTGGGAGTAAAGCACTCAGAAAATGATTCGGTTCCAATG CAAGACACCCAAGTCCTTCCTGATATAGAGACTCTAATTGGTGTACAAAATCCCTCTTTA CTTAAAGGTAAGAGCCAAGAGACAACTCAGTTTTGGTCCCAAAGAGTTGAGGATTCCAAG ATCAATATCCCTACCCACAGTGGCCCTGCAGCTGAGATCCTTCCTGGGCCACTGGAAGGG ACACGCTGTGGTGAAGGACTATTCTCTGAAGAGACATTGAATGATACCAGTGGTTCCCCA AAAATGTTTGCTCAGGACACAGTGTGTGCTCCTTTTCCCCAAAGAGCAACCCCCAAAGTT ACCTCTCAAGGAAACCCCAGCATTCAGTTAGAAGAGTTGGGTTCACGAGTAGAATCTCTT AAGTTATCTGATTCTTACCTGGATCCCATTAAAAGTGAACATGATTGCTACCCCACCTCC AGTCTTAATAAGGTTATACCTGACTTGAACCTTAGAAACTGCTTGGCTCTTGGTGGGTCT ACGTCTCCTACCTCTGTAATAAAATTCCTCTTGGCAGGCTCAAAACAAGCGACCCTTGGT GCTAAACCAGATCATCAAGAGGCCTTCGAAGCTACTGCAAATCAACAGGAAGTTTCTGAT ACCACCTCTTTCCTAGGACAGGCCTTTGGTGCTATCCCACATCAATGGGAACTTCCTGGT GCTGACCCAGTTCATGGTGAGGCCCTGGGTGAGACCCCAGATCTACCAGAGATTCCTGGT GCTATTCCAGTCCAAGGAGAGGTCTTTGGTACTATTTTAGACCAACAAGAAACTCTTGGT ATGAGTGGGAGTGTTGTCCCAGACTTGCCTGTCTTCCTTCCTGTTCCTCCAAATCCAATT GCTACCTTTAATGCTCCTTCCAAATGGCCTGAGCCCCAAAGCACTGTCTCATATGGACTT GCAGTCCAGGGTGCTATACAGATTTTGCCTTTGGGCTCAGGACACACTCCTCAATCATCA TCAAACTCAGAGAAAAATTCATTACCTCCAGTAATGGCTATAAGCAATGTAGAAAATGAG AAGCAGGTTCATATAAGCTTCCTGCCAGCTAACACTCAGGGGTTCCCATTAGCCCCTGAG AGAGGACTCTTCCATGCTTCACTGGGTATAGCCCAACTCTCTCAGGCTGGTCCTAGCAAA TCAGACAGAGGGAGCTCCCAGGTCAGTGTAACCAGCACAGTTCATGTTGTCAACACCACA GTGGTGACTATGCCAGTGCCAATGGTCAGTACCTCCTCTTCTTCCTATACCACTTTGCTA CCGACTTTGGAAAAGAAGAAAAGAAAGCGATGTGGGGTCTGTGAACCCTGCCAGCAGAAG ACCAACTGTGGTGAATGCACTTACTGCAAGAACAGAAAGAACAGCCATCAGATCTGTAAG AAAAGAAAATGTGAGGAGCTGAAAAAGAAACCATCTGTTGTTGTGCCTCTGGAGGTTATA AAGGAAAACAAGAGGCCCCAGAGGGAAAAGAAGCCCAAAGTTTTAAAGGCAGATTTTGAC AACAAACCAGTAAATGGCCCCAAGTCAGAATCCATGGACTACAGTAGATGTGGTCATGGG GAAGAACAAAAATTGGAATTGAACCCACATACTGTTGAAAATGTAACTAAAAATGAAGAC AGCATGACAGGCATCGAGGTGGAGAAGTGGACACAAAACAAGAAATCACAGTTAACTGAT CACGTGAAAGGAGATTTTAGTGCTAATGTCCCAGAAGCTGAAAAATCGAAAAACTCTGAA GTTGACAAGAAACGAACCAAATCTCCAAAATTGTTTGTACAAACCGTAAGAAATGGCATT AAACATGTACACTGTTTACCAGCTGAAACAAATGTTTCATTTAAAAAATTCAATATTGAA GAATTCGGCAAGACATTGGAAAACAATTCTTATAAATTCCTAAAAGACACTGCAAACCAT AAAAACGCTATGAGCTCTGTTGCTACTGATATGAGTTGTGATCATCTCAAGGGGAGAAGT AACGTTTTAGTATTCCAGCAGCCTGGCTTTAACTGCAGTTCCATTCCACATTCTTCACAC TCCATCATAAATCATCATGCTAGTATACACAATGAAGGTGATCAACCAAAAACTCCTGAG AATATACCAAGTAAAGAACCAAAAGATGGATCTCCCGTTCAACCAAGTCTCTTATCGTTA ATGAAAGATAGGAGATTAACATTGGAGCAAGTGGTAGCCATAGAGGCCCTGACTCAACTC TCAGAAGCCCCATCAGAGAATTCCTCCCCATCAAAGTCAGAGAAGGATGAGGAATCAGAG CAGAGAACAGCCAGTTTGCTTAATAGCTGCAAAGCTATCCTCTACACTGTAAGAAAAGAC CTCCAAGACCCAAACTTACAGGGAGAGCCACCAAAACTTAATCACTGTCCATCTTTGGAA AAACAAAGTTCATGCAACACGGTGGTTTTCAATGGGCAAACTACTACCCTTTCCAACTCA CATATCAACTCAGCTACTAACCAAGCATCCACAAAGTCACATGAATATTCAAAAGTCACA AATTCATTATCTCTTTTTATACCAAAATCAAATTCATCCAAGATTGACACCAATAAAAGT ATTGCTCAAGGGATAATTACTCTTGACAATTGTTCCAATGATTTGCATCAGTTGCCACCA AGAAATAATGAAGTGGAGTATTGCAACCAGTTACTGGACAGCAGCAAAAAATTGGACTCA GATGATCTATCATGTCAGGATGCAACCCATACCCAAATTGAGGAAGATGTTGCAACACAG TTGACACAACTTGCTTCGATAATTAAGATCAATTATATAAAACCAGAGGACAAAAAAGTT GAAAGTACACCAACAAGCCTTGTCACATGTAATGTACAGCAAAAATACAATCAGGAGAAG GGCACAATACAACAGAAACCACCTTCAAGTGTACACAATAATCATGGTTCATCATTAACA AAACAAAAGAACCCAACCCAGAAAAAGACAAAATCCACCCCATCAAGAGATCGGCGGAAA AAGAAGCCCACAGTTGTAAGTTATCAAGAAAATGATCGGCAGAAGTGGGAAAAGTTGTCC TATATGTATGGCACAATATGCGACATTTGGATAGCATCGAAATTTCAAAATTTTGGGCAA TTTTGTCCACATGATTTTCCTACTGTATTTGGGAAAATTTCTTCCTCGACCAAAATATGG AAACCACTGGCTCAAACGAGGTCCATTATGCAACCCAAAACAGTATTTCCACCACTCACT CAGATAAAATTACAGAGATATCCTGAATCAGCAGAGGAAAAGGTGAAGGTTGAACCATTG GATTCACTCAGCTTATTTCATCTTAAAACGGAATCCAACGGGAAGGCATTCACTGATAAA GCTTATAATTCTCAGGTACAGTTAACGGTGAATGCCAATCAGAAAGCCCATCCTTTGACC CAGCCCTCCTCTCCACCTAACCAGTGTGCTAACGTGATGGCAGGCGATGACCAAATACGG TTTCAGCAGGTTGTTAAGGAGCAACTCATGCATCAGAGACTGCCAACATTGCCTGGTATC TCTCATGAAACACCCTTACCGGAGTCAGCACTAACTCTCAGGAATGTAAATGTAGTGTGT TCAGGTGGAATTACAGTGGTTTCTACCAAAAGTGAAGAGGAAGTCTGTTCATCCAGTTTT GGAACATCAGAATTTTCCACAGTGGACAGTGCACAGAAAAATTTTAATGATTATGCCATG AACTTCTTTACTAACCCTACAAAAAACCTAGTGTCTATAACTAAAGATTCTGAACTGCCC ACCTGCAGCTGTCTTGATCGAGTTATACAAAAAGACAAAGGCCCATATTATACACACCTT GGGGCAGGACCAAGTGTTGCTGCTGTCAGGGAAATCATGGAGAATAGGTATGGTCAAAAA GGAAACGCAATAAGGATAGAAATAGTAGTGTACACCGGTAAAGAAGGGAAAAGCTCTCAT GGGTGTCCAATTGCTAAGTGGGTTTTAAGAAGAAGCAGTGATGAAGAAAAAGTTCTTTGT TTGGTCCGGCAGCGTACAGGCCACCACTGTCCAACTGCTGTGATGGTGGTGCTCATCATG GTGTGGGATGGCATCCCTCTTCCAATGGCCGACCGGCTATACACAGAGCTCACAGAGAAT CTAAAGTCATACAATGGGCACCCTACCGACAGAAGATGCACCCTCAATGAAAATCGTACC TGTACATGTCAAGGAATTGATCCAGAGACTTGTGGAGCTTCATTCTCTTTTGGCTGTTCA TGGAGTATGTACTTTAATGGCTGTAAGTTTGGTAGAAGCCCAAGCCCCAGAAGATTTAGA ATTGATCCAAGCTCTCCCTTACATGAAAAAAACCTTGAAGATAACTTACAGAGTTTGGCT ACACGATTAGCTCCAATTTATAAGCAGTATGCTCCAGTAGCTTACCAAAATCAGGTGGAA TATGAAAATGTTGCCCGAGAATGTCGGCTTGGCAGCAAGGAAGGTCGTCCCTTCTCTGGG GTCACTGCTTGCCTGGACTTCTGTGCTCATCCCCACAGGGACATTCACAACATGAATAAT GGAAGCACTGTGGTTTGTACCTTAACTCGAGAAGATAACCGCTCTTTGGGTGTTATTCCT CAAGATGAGCAGCTCCATGTGCTACCTCTTTATAAGCTTTCAGACACAGATGAGTTTGGC TCCAAGGAAGGAATGGAAGCCAAGATCAAATCTGGGGCCATCGAGGTCCTGGCACCCCGC CGCAAAAAAAGAACGTGTTTCACTCAGCCTGTTCCCCGTTCTGGAAAGAAGAGGGCTGCG ATGATGACAGAGGTTCTTGCACATAAGATAAGGGCAGTGGAAAAGAAACCTATTCCCCGA ATCAAGCGGAAGAATAACTCAACAACAACAAACAACAGTAAGCCTTCGTCACTGCCAACC TTAGGGAGTAACACTGAGACCGTGCAACCTGAAGTAAAAAGTGAAACCGAACCCCATTTT ATCTTAAAAAGTTCAGACAACACTAAAACTTATTCGCTGATGCCATCCGCTCCTCACCCA GTGAAAGAGGCATCTCCAGGCTTCTCCTGGTCCCCGAAGACTGCTTCAGCCACACCAGCT CCACTGAAGAATGACGCAACAGCCTCATGCGGGTTTTCAGAAAGAAGCAGCACTCCCCAC TGTACGATGCCTTCGGGAAGACTCAGTGGTGCCAATGCAGCTGCTGCTGATGGCCCTGGC ATTTCACAGCTTGGCGAAGTGGCTCCTCTCCCCACCCTGTCTGCTCCTGTGATGGAGCCC CTCATTAATTCTGAGCCTTCCACTGGTGTGACTGAGCCGCTAACGCCTCATCAGCCAAAC CACCAGCCCTCCTTCCTCACCTCTCCTCAAGACCTTGCCTCTTCTCCAATGGAAGAAGAT GAGCAGCATTCTGAAGCAGATGAGCCTCCATCAGACGAACCCCTATCTGATGACCCCCTG TCACCTGCTGAGGAGAAATTGCCCCACATTGATGAGTATTGGTCAGACAGTGAGCACATC TTTTTGGATGCAAATATTGGTGGGGTGGCCATCGCACCTGCTCACGGCTCGGTTTTGATT GAGTGTGCCCGGCGAGAGCTGCACGCTACCACTCCTGTTGAGCACCCCAACCGTAATCAT CCAACCCGCCTCTCCCTTGTCTTTTACCAGCACAAAAACCTAAATAAGCCCCAACATGGT TTTGAACTAAACAAGATTAAGTTTGAGGCTAAAGAAGCTAAGAATAAGAAAATGAAGGCC TCAGAGCAAAAAGACCAGGCAGCTAATGAAGGTCCAGAACAGTCCTCTGAAGTAAATGAA TTGAACCAAATTCCTTCTCATAAAGCATTAACATTAACCCATGACAATGTTGTCACCGTG TCCCCTTATGCTCTCACACACGTTGCGGGGCCCTATAACCATTGGGTCTGA
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:29484
Chromosome Location	10
Locus	Not Available
References	Ono R, Taki T, Taketani T, Taniwaki M, Kobayashi H, Hayashi Y: LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23). Cancer Res. 2002 Jul 15;62(14):4075-80. 12124344 Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J: The DNA sequence and comparative analysis of human chromosome 10. Nature. 2004 May 27;429(6990):375-81. 15164054 Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O: Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 2000 Dec 31;7(6):347-55. 11214970 Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. 17974005 Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334 Lorsbach RB, Moore J, Mathew S, Raimondi SC, Mukatira ST, Downing JR: TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23). Leukemia. 2003 Mar;17(3):637-41. 12646957 Kriaucionis S, Heintz N: The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science. 2009 May 15;324(5929):929-30. doi: 10.1126/science.1169786. Epub 2009 Apr 16. 19372393 Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, Agarwal S, Iyer LM, Liu DR, Aravind L, Rao A: Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science. 2009 May 15;324(5929):930-5. doi: 10.1126/science.1170116. Epub 2009 Apr 16. 19372391 Guo JU, Su Y, Zhong C, Ming GL, Song H: Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell. 2011 Apr 29;145(3):423-34. doi: 10.1016/j.cell.2011.03.022. Epub 2011 Apr 14. 21496894 Williams K, Christensen J, Pedersen MT, Johansen JV, Cloos PA, Rappsilber J, Helin K: TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature. 2011 May 19;473(7347):343-8. doi: 10.1038/nature10066. Epub 2011 Apr 13. 21490601 Ito S, Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA, He C, Zhang Y: Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science. 2011 Sep 2;333(6047):1300-3. doi: 10.1126/science.1210597. Epub 2011 Jul 21. 21778364