Prostaglandin reductase 2
Name | Prostaglandin reductase 2 |
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Synonyms |
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Gene Name | PTGR2 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0006859|Prostaglandin reductase 2 MIVQRVVLNSRPGKNGNPVAENFRMEEVYLPDNINEGQVQVRTLYLSVDPYMRCRMNEDT GTDYITPWQLSQVVDGGGIGIIEESKHTNLTKGDFVTSFYWPWQTKVILDGNSLEKVDPQ LVDGHLSYFLGAIGMPGLTSLIGIQEKGHITAGSNKTMVVSGAAGACGSVAGQIGHFLGC SRVVGICGTHEKCILLTSELGFDAAINYKKDNVAEQLRESCPAGVDVYFDNVGGNISDTV ISQMNENSHIILCGQISQYNKDVPYPPPLSPAIEAIQKERNITRERFLVLNYKDKFEPGI LQLSQWFKEGKLKIKETVINGLENMGAAFQSMMTGGNIGKQIVCISEEISL |
Number of residues | 351 |
Molecular Weight | 38498.74 |
Theoretical pI | 5.08 |
GO Classification | Functions
Processes
Components
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General Function | 15-oxoprostaglandin 13-oxidase activity |
Specific Function | Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity). |
Pfam Domain Function |
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Transmembrane Regions | Not Available |
GenBank Protein ID | 37912002 |
UniProtKB ID | Q8N8N7 |
UniProtKB Entry Name | PTGR2_HUMAN |
Cellular Location | Cytoplasm |
Gene sequence | >lcl|BSEQ0012477|Prostaglandin reductase 2 (PTGR2) ATGATTGTTCAAAGAGTGGTATTGAATTCTCGACCTGGAAAAAATGGTAATCCAGTGGCA GAGAATTTCCGAATGGAAGAAGTCTATTTACCAGATAATATTAATGAAGGACAAGTACAA GTTAGAACTCTTTATCTTTCTGTGGATCCTTACATGCGTTGTAGAATGAATGAAGACACT GGCACTGATTATATAACACCTTGGCAGCTATCTCAAGTCGTTGATGGAGGAGGTATTGGA ATTATAGAAGAAAGCAAACACACAAATTTGACTAAAGGCGATTTTGTGACTTCTTTCTAT TGGCCCTGGCAAACCAAGGTTATTCTGGATGGAAATAGCCTTGAAAAGGTAGACCCACAA CTTGTGGATGGACACCTTTCATATTTTCTTGGAGCTATAGGTATGCCTGGTTTGACTTCC TTGATTGGGATACAGGAAAAAGGTCATATAACTGCTGGATCTAATAAGACAATGGTTGTC AGTGGGGCCGCAGGTGCCTGTGGATCTGTGGCTGGGCAGATTGGCCATTTCTTAGGTTGT TCCAGAGTGGTGGGAATTTGTGGAACACATGAGAAATGCATCCTCTTGACCTCAGAACTG GGCTTTGATGCTGCAATTAATTATAAAAAAGACAATGTGGCAGAACAGCTCCGTGAATCA TGCCCAGCTGGAGTGGATGTTTATTTTGACAATGTTGGTGGTAACATCAGTGATACAGTG ATAAGTCAGATGAATGAGAACAGCCACATCATCCTGTGTGGTCAAATTTCTCAGTACAAC AAAGATGTGCCTTATCCTCCCCCGCTATCCCCTGCTATAGAGGCAATCCAGAAAGAAAGA AACATCACAAGGGAAAGATTTCTGGTATTAAATTATAAAGACAAATTTGAGCCTGGCATT CTACAGCTGAGTCAGTGGTTTAAAGAAGGAAAGCTAAAGATTAAAGAGACGGTAATAAAT GGGTTGGAAAACATGGGAGCTGCATTCCAGTCCATGATGACAGGAGGTAACATTGGAAAG CAGATAGTTTGCATTTCAGAAGAAATCTCTTTGTAA |
GenBank Gene ID | AY346133 |
GeneCard ID | Not Available |
GenAtlas ID | Not Available |
HGNC ID | HGNC:20149 |
Chromosome Location | 14 |
Locus | 14q24.3 |
References |
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