NameVitamin K epoxide reductase complex subunit 1-like protein 1
Synonyms
  • 1.17.4.4
  • VKORC1-like protein 1
Gene NameVKORC1L1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004573|Vitamin K epoxide reductase complex subunit 1-like protein 1
MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSA
ALASRWGRGFGLLGSIFGKDGVLNQPNSVFGLIFYILQLLLGMTASAVAALILMTSSIMS
VVGSLYLAYILYFVLKEFCIICIVTYVLNFLLLIINYKRLVYLNEAWKRQLQPKQD
Number of residues176
Molecular Weight19835.425
Theoretical pI9.35
GO Classification
Functions
  • quinone binding
  • vitamin-K-epoxide reductase (warfarin-sensitive) activity
Processes
  • peptidyl-glutamic acid carboxylation
  • cellular response to oxidative stress
  • vitamin K metabolic process
Components
  • endoplasmic reticulum membrane
  • integral component of membrane
General FunctionVitamin-k-epoxide reductase (warfarin-sensitive) activity
Specific FunctionInvolved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins.
Pfam Domain Function
Transmembrane Regions17-37 92-112 114-134 135-155
GenBank Protein ID40217985
UniProtKB IDQ8N0U8
UniProtKB Entry NameVKORL_HUMAN
Cellular LocationEndoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0011676|Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1)
ATGGCGGCTCCCGTCCTGCTAAGAGTGTCGGTGCCGCGGTGGGAGCGGGTGGCCCGGTAT
GCAGTGTGCGCTGCCGGAATCCTGCTCTCCATCTACGCCTACCACGTGGAGCGGGAGAAG
GAGCGGGACCCCGAGCACCGGGCCCTCTGCGACCTGGGGCCCTGGGTGAAGTGCTCCGCC
GCCCTTGCCTCCAGGCATGACAGCAAGCGCTGTGGCGGCTTTGATCCTCATGACGTCCTC
CATCATGTCGGTCGTGGGGTCCCTGTACCTGGCCTACATTCTGTACTTTGTGCTGAAGGA
GTTCTGCATCATCTGCATCGTCACGTACGTGCTGAACTTCCTTCTTCTCATTATCAACTA
CAAACGACTAGTTTACTTGAACGAGGCCTGGAAGCGGCAGCTGCAACCCAAGCAGGACTG
ACGCCCGACAGACTCCACCCTAACAGTCTCAAGCCCCTTTCCATTCAGTTTATTTTGCAG
CAGGTTTTTATTATTATTATTATTATTATTATTCACAACAGACACTTTCCCTAA
GenBank Gene IDAY423045
GeneCard IDNot Available
GenAtlas IDVKORC1L1
HGNC IDHGNC:21492
Chromosome Location7
Locus7q11.21
References
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