T3DB: Kinesin-like protein KIF18B

Name	Kinesin-like protein KIF18B
Synonyms	Not Available
Gene Name	KIF18B
Organism	Human
Amino acid sequence	>lcl\|BSEQ0009139\|Kinesin-like protein KIF18B MSHPGVTTVMAVEDSTLQVVVRVRPPTPRELDSQRRPVVQVVDERVLVFNPEEPDGGFPG LKWGGTHDGPKKKGKDLTFVFDRVFGEAATQQDVFQHTTHSVLDSFLQGYNCSVFAYGAT GAGKTHTMLGREGDPGIMYLTTVELYRRLEARQQEKHFEVLISYQEVYNEQIHDLLEPKG PLAIREDPDKGVVVQGLSFHQPASAEQLLEILTRGNRNRTQHPTDANATSSRSHAIFQIF VKQQDRVPGLTQAVQVAKMSLIDLAGSERASSTHAKGERLREGANINRSLLALINVLNAL ADAKGRKTHVPYRDSKLTRLLKDSLGGNCRTVMIAAISPSSLTYEDTYNTLKYADRAKEI RLSLKSNVTSLDCHISQYATICQQLQAEVAALRKKLQVYEGGGQPPPQDLPGSPKSGPPP EHLPSSPLPPHPPSQPCTPELPAGPRALQEESLGMEAQVERAMEGNSSDQEQSPEDEDEG PAEEVPTQMPEQNPTHALPESPRLTLQPKPVVGHFSARELDGDRSKQLALKVLCVAQRQY SLLQAANLLTPDMITEFETLQQLVQEEKIEPGAEALRTSGLARGAPLAQELCSESKPPGY TGPVTRTMARRLSGPLHTLGIPPGPNCTPAQGSRWPMEKKRRRPSALEADSPMAPKRGTK RQRQSFLPCLRRGSLPDTQPSQGPSTPKGERASSPCHSPRVCPATVIKSRVPLGPSAMQN CSTPLALPTRDLNATFDLSEEPPSKPSFHECIGWDKIPQELSRLDQPFIPRAPVPLFTMK GPKPTSSLPGTSACKKKRVASSSVSHGRSRIARLPSSTLKRPAGPLVLPELPLSPLCPSN RRNGKDLIRVGRALSAGNGVTKVS
Number of residues	864
Molecular Weight	94222.305
Theoretical pI	Not Available
GO Classification	Functions ATP-dependent microtubule motor activity, plus-end-directed kinesin binding ATP binding motor activity Processes microtubule depolymerization mitotic sister chromatid segregation regulation of cell division microtubule-based movement cell division mitotic cell cycle Components microtubule plus-end astral microtubule microtubule end cytoplasm nucleus kinesin complex
General Function	Motor activity
Specific Function	In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules.
Pfam Domain Function	Kinesin (PF00225 )
Transmembrane Regions	Not Available
GenBank Protein ID	Not Available
UniProtKB ID	Q86Y91
UniProtKB Entry Name	KI18B_HUMAN
Cellular Location	Nucleus
Gene sequence	>lcl\|BSEQ0021446\|Kinesin-like protein KIF18B (KIF18B) ATGGCAGTGGAGGACAGCACGCTGCAAGTAGTGGTACGGGTGCGGCCCCCCACCCCTCGG GAGCTGGACAGTCAGCGGCGGCCAGTGGTTCAGGTGGTGGACGAGCGGGTGCTGGTGTTT AACCCTGAGGAGCCCGATGGAGGGTTCCCTGGCCTGAAATGGGGTGGCACCCATGATGGC CCCAAGAAGAAGGGCAAAGACCTGACGTTTGTCTTTGACCGGGTCTTTGGCGAGGCGGCC ACCCAACAGGACGTGTTCCAGCACACCACGCACAGCGTCCTGGACAGCTTCCTCCAGGGC TACAACTGCTCAGTGTTTGCCTACGGGGCCACCGGGGCTGGGAAGACACACACCATGCTG GGAAGGGAGGGGGACCCCGGCATCATGTACCTGACCACCGTGGAACTGTACAGGCGCCTG GAGGCCCGCCAGCAGGAGAAGCACTTCGAGGTGCTCATCAGCTACCAGGAGGTGTATAAT GAACAGATCCATGACCTCCTGGAGCCCAAGGGGCCCCTTGCCATCCGCGAGGACCCCGAC AAGGGGGTGGTGGTGCAAGGACTTTCTTTCCACCAGCCAGCCTCAGCCGAGCAGCTGCTG GAGATACTGACCAGGGGGAACCGTAACCGCACGCAGCACCCCACTGATGCCAACGCGACT TCCTCCCGCTCCCATGCCATCTTCCAGATCTTTGTGAAGCAGCAGGACCGGGTTCCAGGA CTGACCCAGGCTGTCCAGGTGGCCAAGATGAGCCTGATTGACCTGGCTGGCTCAGAGCGG GCATCCAGCACCCATGCGAAGGGGGAGCGGCTGCGGGAGGGGGCCAACATCAACCGCTCT CTGCTGGCGCTCATCAACGTCCTCAATGCCTTGGCCGATGCAAAGGGCCGCAAGACCCAT GTGCCCTACCGGGACAGCAAACTGACCCGCCTGCTCAAAGACTCCCTCGGGGGCAACTGC CGCACAGTGATGATCGCTGCCATCAGCCCCTCCAGCCTGACCTACGAGGACACGTACAAC ACCCTCAAATATGCCGACCGGGCCAAGGAGATCAGGCTCTCGCTGAAGAGCAATGTGACC AGCCTGGACTGTCACATCAGCCAGTATGCTACCATCTGCCAACAGCTCCAGGCTGAGGTA GCCGCTCTGAGGAAGAAGCTCCAAGTGTATGAGGGGGGAGGCCAGCCCCCACCACAGGAC CTCCCAGGATCTCCCAAGTCGGGACCACCACCAGAACACCTTCCCAGCTCCCCCTTGCCA CCCCACCCTCCCAGCCAGCCCTGCACCCCAGAGCTCCCTGCAGGGCCTAGAGCCCTTCAA GAGGAGAGTCTGGGGATGGAGGCCCAGGTGGAGAGGGCCATGGAAGGGAACTCTTCAGAC CAGGAGCAGTCCCCAGAGGATGAGGATGAAGGCCCAGCTGAGGAGGTTCCAACCCAGATG CCAGAGCAGAACCCCACACATGCACTGCCAGAGTCCCCTCGCCTGACCCTGCAGCCCAAG CCAGTCGTGGGCCACTTCTCAGCACGGGAACTGGATGGGGACCGTTCTAAGCAGTTGGCC CTAAAGGTGCTGTGCGTTGCCCAGCGGCAGTACTCCCTGCTCCAAGCAGCCAACCTCCTG ACGCCCGACATGATCACAGAGTTTGAGACCCTACAGCAGCTGGTGCAAGAGGAAAAAATT GAGCCTGGGGCAGAGGCCTTGAGGACTTCAGGCCTGGCCAGGGGGGCACCTCTGGCTCAG GAGCTGTGTTCAGAGTCAATCCCTGTGCCGTCTCCTCTCTGCCCAGAGCCTCCAGGATAC ACTGGCCCTGTGACCCGGACTATGGCGAGGCGACTGAGTGGCCCCCTGCACACCCTGGGA ATCCCGCCTGGACCCAACTGCACCCCAGCCCAGGGGTCCCGATGGCCCATGGAGAAGAAG AGGAGGAGACCAAGCGCCTTGGAGGCAGACAGTCCCATGGCCCCAAAGCGGGGCACCAAG CGCCAGCGCCAGTCCTTCCTGCCCTGCCTAAGGAGAGGGTCTCTGCCTGACACCCAACCT TCACAGGGGCCCAGCACCCCCAAAGGAGAAAGGGCCTCCTCCCCCTGCCATTCCCCTCGC GTTTGCCCAGCCACAGTCATCAAAAGCCGGGTGCCCCTGGGCCCTTCCGCCATGCAGAAC TGCTCCACCCCGCTGGCTCTGCCCACTCGAGACCTCAATGCCACCTTTGATCTCTCTGAG GAGCCTCCCTCAAAGCCCAGTTTCCATGAATGCATTGGCTGGGACAAAATACCCCAGGAG CTGAGCAGGCTGGACCAGCCCTTCATCCCCAGGGCACCTGTGCCCCTGTTCACCATGAAG GGCCCCAAGCCAACATCTTCCCTCCCTGGGACCTCTGCCTGCAAGAAGAAGCGCGTTGCG AGTTCCTCAGTCTCCCATGGCCGCAGCCGCATCGCCCGCCTCCCCAGCAGCACTTTGAAG AGGCCAGCTGGGCCCCTTGTACTCCCAGGTGACTGGCACTAG
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:27102
Chromosome Location	17
Locus	Not Available
References	Lee YM, Kim E, Park M, Moon E, Ahn SM, Kim W, Hwang KB, Kim YK, Choi W, Kim W: Cell cycle-regulated expression and subcellular localization of a kinesin-8 member human KIF18B. Gene. 2010 Oct 15;466(1-2):16-25. doi: 10.1016/j.gene.2010.06.007. Epub 2010 Jun 23. 20600703 Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen NR, Bi W, Bloom T, Borowsky ML, Bugalter BE, Butler J, Chang JL, Chen CK, Cook A, Corum B, Cuomo CA, de Jong PJ, DeCaprio D, Dewar K, FitzGerald M, Gilbert J, Gibson R, Gnerre S, Goldstein S, Grafham DV, Grocock R, Hafez N, Hagopian DS, Hart E, Norman CH, Humphray S, Jaffe DB, Jones M, Kamal M, Khodiyar VK, LaButti K, Laird G, Lehoczky J, Liu X, Lokyitsang T, Loveland J, Lui A, Macdonald P, Major JE, Matthews L, Mauceli E, McCarroll SA, Mihalev AH, Mudge J, Nguyen C, Nicol R, O'Leary SB, Osoegawa K, Schwartz DC, Shaw-Smith C, Stankiewicz P, Steward C, Swarbreck D, Venkataraman V, Whittaker CA, Yang X, Zimmer AR, Bradley A, Hubbard T, Birren BW, Rogers J, Lander ES, Nusbaum C: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Nature. 2006 Apr 20;440(7087):1045-9. 16625196 Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334 Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR 3rd: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. J Proteome Res. 2008 Mar;7(3):1346-51. doi: 10.1021/pr0705441. Epub 2008 Jan 26. 18220336 Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. 18691976 Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. 18669648 Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475. 20068231 Tanenbaum ME, Macurek L, van der Vaart B, Galli M, Akhmanova A, Medema RH: A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases. Curr Biol. 2011 Aug 23;21(16):1356-65. doi: 10.1016/j.cub.2011.07.017. Epub 2011 Aug 4. 21820309 Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal. 2011 Mar 15;4(164):rs3. doi: 10.1126/scisignal.2001570. 21406692