Protein phosphatase 1 regulatory subunit 3B

NameProtein phosphatase 1 regulatory subunit 3B
Synonyms
  • Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL
  • PP1 subunit R4
  • PPP1R4
  • Protein phosphatase 1 regulatory subunit 4
  • Protein phosphatase 1 subunit GL
  • PTG
Gene NamePPP1R3B
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013629|Protein phosphatase 1 regulatory subunit 3B
MMAVDIEYRYNCMAPSLRQERFAFKISPKPSKPLRPCIQLSSKNEASGMVAPAVQEKKVK
KRVSFADNQGLALTMVKVFSEFDDPLDMPFNITELLDNIVSLTTAESESFVLDFSQPSAD
YLDFRNRLQADHVCLENCVLKDKAIAGTVKVQNLAFEKTVKIRMTFDTWKSYTDFPCQYV
KDTYAGSDRDTFSFDISLPEKIQSYERMEFAVYYECNGQTYWDSNRGKNYRIIRAELKST
QGMTKPHSGPDLGISFDQFGSPRCSYGLFPEWPSYLGYEKLGPYY
Number of residues285
Molecular Weight32694.86
Theoretical pINot Available
GO Classification
Functions
  • phosphoprotein phosphatase activity
  • protein phosphatase regulator activity
Processes
  • regulation of glycogen biosynthetic process
  • regulation of glycogen catabolic process
  • glycogen metabolic process
Components
  • protein phosphatase type 1 complex
  • intracellular membrane-bounded organelle
  • glycogen granule
General FunctionProtein phosphatase regulator activity
Specific FunctionActs as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ86XI6
UniProtKB Entry NamePPR3B_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0013630|Protein phosphatase 1 regulatory subunit 3B (PPP1R3B)
ATGATGGCTGTGGACATCGAGTACAGATACAACTGCATGGCTCCTTCCTTGCGCCAAGAG
AGGTTTGCCTTTAAGATCTCACCAAAGCCCAGCAAACCACTGAGGCCTTGTATTCAGCTG
AGCAGCAAGAATGAAGCCAGTGGAATGGTGGCCCCGGCTGTCCAGGAGAAGAAGGTGAAA
AAGCGGGTGTCCTTCGCAGACAACCAGGGGCTGGCCCTGACAATGGTCAAAGTGTTCTCG
GAATTCGATGACCCGCTAGATATGCCATTCAACATCACCGAGCTCCTAGACAACATTGTG
AGCTTGACGACAGCAGAGAGCGAGAGCTTTGTTCTGGATTTTTCCCAGCCCTCTGCAGAT
TACTTAGACTTTAGAAATCGACTTCAGGCCGACCACGTCTGCCTTGAGAACTGTGTGCTC
AAGGACAAGGCCATTGCAGGCACTGTGAAGGTTCAGAACCTCGCATTTGAGAAGACCGTG
AAAATAAGGATGACGTTCGACACCTGGAAGAGCTACACAGACTTTCCTTGTCAGTACGTG
AAGGACACTTATGCCGGTTCAGACAGGGACACGTTCTCCTTCGACATCAGCTTGCCCGAG
AAGATTCAGTCTTATGAAAGAATGGAGTTTGCTGTGTACTACGAGTGCAATGGACAGACG
TACTGGGACAGCAACAGAGGCAAGAACTATAGGATCATCCGGGCTGAGTTAAAATCTACC
CAGGGAATGACCAAGCCCCACAGTGGACCGGATTTGGGAATATCCTTTGACCAGTTCGGA
AGCCCTCGGTGTTCCTATGGTCTGTTTCCAGAGTGGCCAAGTTACTTAGGATATGAAAAG
CTAGGGCCCTACTACTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:14942
Chromosome Location8
LocusNot Available
References
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