NameHistone H2B type W-T
Synonyms
  • H2B histone family member W testis-specific
Gene NameH2BFWT
OrganismHuman
Amino acid sequence
>lcl|BSEQ0017643|Histone H2B type W-T
MLRTEVPRLPRSTTAIVWSCHLMATASAMAGPSSETTSEEQLITQEPKEANSTTSQKQSK
QRKRGRHGPRRCHSNCRGDSFATYFRRVLKQVHQGLSLSREAVSVMDSLVHDILDRIATE
AGRLARSTKRQTITAWETRMAVRLLLPGQMGKLAESEGTKAVLRTSLYAIQQQRK
Number of residues175
Molecular Weight19618.3
Theoretical pINot Available
GO Classification
Functions
  • DNA binding
Processes
  • nucleosome assembly
Components
  • nuclear membrane
  • nuclear nucleosome
General FunctionDna binding
Specific FunctionAtypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes. May be important for telomere function.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ7Z2G1
UniProtKB Entry NameH2BWT_HUMAN
Cellular LocationNucleus membrane
Gene sequence
>lcl|BSEQ0017644|Histone H2B type W-T (H2BFWT)
ATGCTGCGTACCGAAGTGCCCCGGCTTCCCCGGTCCACAACCGCCATTGTCTGGTCGTGC
CATCTAATGGCCACTGCCTCCGCCATGGCTGGACCTTCCTCTGAGACGACCTCTGAGGAA
CAGCTGATCACCCAGGAGCCCAAAGAGGCCAACTCCACTACGTCCCAGAAGCAGAGCAAG
CAGAGGAAGCGAGGGCGCCATGGGCCCCGCAGGTGCCACTCCAACTGCCGCGGGGACAGC
TTCGCCACCTATTTCCGCCGGGTGCTGAAGCAGGTTCACCAGGGCCTCAGCCTTTCCCGG
GAGGCCGTGAGTGTCATGGATTCTTTGGTTCATGACATATTGGACCGCATCGCCACCGAG
GCTGGTCACCTGGCCCGCTCCACCAAGCGCCAGACCATCACTGCCTGGGAGACCCGGATG
GCTGTGCGCCTGCTGCTGCCGGGGCAGATGGGCAAGCTCGCCGAGTCCGAAGGCACGAAG
GCTGTCCTCAGAACTTCACTGTATGCCATACAGCAACAGAGAAAGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:27252
Chromosome LocationX
LocusNot Available
References
  1. Churikov D, Siino J, Svetlova M, Zhang K, Gineitis A, Morton Bradbury E, Zalensky A: Novel human testis-specific histone H2B encoded by the interrupted gene on the X chromosome. Genomics. 2004 Oct;84(4):745-56. 15475252
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  4. Boulard M, Gautier T, Mbele GO, Gerson V, Hamiche A, Angelov D, Bouvet P, Dimitrov S: The NH2 tail of the novel histone variant H2BFWT exhibits properties distinct from conventional H2B with respect to the assembly of mitotic chromosomes. Mol Cell Biol. 2006 Feb;26(4):1518-26. 16449661