Ribonucleoside-diphosphate reductase subunit M2 B

NameRibonucleoside-diphosphate reductase subunit M2 B
Synonyms
  • 1.17.4.1
  • p53-inducible ribonucleotide reductase small subunit 2-like protein
  • P53R2
  • TP53-inducible ribonucleotide reductase M2 B
Gene NameRRM2B
OrganismHuman
Amino acid sequence
>lcl|BSEQ0006951|Ribonucleoside-diphosphate reductase subunit M2 B
MGDPERPEAAGLDQDERSSSDTNESEIKSNEEPLLRKSSRRFVIFPIQYPDIWKMYKQAQ
ASFWTAEEVDLSKDLPHWNKLKADEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEA
RCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRK
STFGERVVAFAAVEGVFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQ
YLVNKPSEERVREIIVDAVKIEQEFLTEALPVGLIGMNCILMKQYIEFVADRLLVELGFS
KVFQAENPFDFMENISLEGKTNFFEKRVSEYQRFAVMAETTDNVFTLDADF
Number of residues351
Molecular Weight40736.11
Theoretical pI4.61
GO Classification
Functions
  • metal ion binding
  • ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Processes
  • DNA repair
  • renal system process
  • mitochondrial DNA replication
  • deoxyribonucleoside triphosphate metabolic process
  • response to oxidative stress
  • negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
  • gene expression
  • small molecule metabolic process
  • transcription initiation from RNA polymerase II promoter
  • kidney development
  • nucleobase-containing small molecule metabolic process
  • deoxyribonucleotide biosynthetic process
  • nucleobase-containing small molecule interconversion
  • deoxyribonucleoside diphosphate metabolic process
Components
  • ribonucleoside-diphosphate reductase complex
  • cytosol
  • extracellular exosome
  • nucleoplasm
  • cytoplasm
  • mitochondrion
General FunctionRibonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Specific FunctionPlays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID7229086
UniProtKB IDQ7LG56
UniProtKB Entry NameRIR2B_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0021362|Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)
ATGTTGCTGTTGCGTCTTCCCCCTCACCGCAGTCACGCCAGCCCGTTAGATTGCAAGTTG
CAGGACCGCTGTAGGAAATGTTATTCGCCGCGGTCAGGACAGGCCTGTCCGCCCGCCCTC
GCCGCAGCCTGGCTTCGTCGTTGCGAGCGCCGGGGAGGCCGTCCCCGGGGAGGGCGGAGG
AAGGAGCTGACTTTGGGTTTGCGTCCCGCTCGCTGCTCTGCCCCGGGGCCAGCCAAGGAC
GACGCTTGGAGGCCTCAGGCCGGGAGATCATCTTCAGACACCAACGAAAGTGAAATAAAG
TCAAATGAAGAGCCACTCCTAAGAAAGAGTTCTCGCCGGTTTGTCATCTTTCCAATCCAG
TACCCTGATATTTGGAAAATGTATAAACAGGCACAGGCTTCCTTCTGGACAGCAGAAGAG
GTCGACTTATCAAAGGATCTCCCTCACTGGAACAAGCTTAAAGCAGATGAGAAGTACTTC
ATCTCTCACATCTTAGCCTTTTTTGCAGCCAGTGATGGAATTGTAAATGAAAATTTGGTG
GAGCGCTTTAGTCAGGAGGTGCAGGTTCCAGAGGCTCGCTGTTTCTATGGCTTTCAAATT
CTCATCGAGAATGTTCACTCAGAGATGTACAGTTTGCTGATAGACACTTACATCAGAGAT
CCCAAGAAAAGGGAATTTTTATTTAATGCAATTGAAACCATGCCCTATGTTAAGAAAAAA
GCAGATTGGGCCTTGCGATGGATAGCAGATAGAAAATCTACTTTTGGGGAAAGAGTGGTG
GCCTTTGCTGCTGTAGAAGGAGTTTTCTTCTCAGGATCTTTTGCTGCTATATTCTGGCTA
AAGAAGAGAGGTCTTATGCCAGGACTCACTTTTTCCAATGAACTCATCAGCAGAGATGAA
GGACTTCACTGTGACTTTGCTTGCCTGATGTTCCAATACTTAGTAAATAAGCCTTCAGAA
GAAAGGGTCAGGGAGATCATTGTTGATGCTGTCAAAATTGAGCAGGAGTTTTTAACAGAA
GCCTTGCCAGTTGGCCTCATTGGAATGAATTGCATTTTGATGAAACAGTACATTGAGTTT
GTAGCTGACAGATTACTTGTGGAACTTGGATTCTCAAAGGTTTTTCAGGCAGAAAATCCT
TTTGATTTTATGGAAAACATTTCTTTAGAAGGAAAAACAAATTTCTTTGAGAAACGAGTT
TCAGAGTATCAGCGTTTTGCAGTTATGGCAGAAACCACAGATAACGTCTTCACCTTGGAT
GCAGATTTTTAA
GenBank Gene IDAB036063
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:17296
Chromosome Location8
Locus8q23.1
References
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