Neuropeptide S receptor

NameNeuropeptide S receptor
Synonyms
  • G-protein coupled receptor 154
  • G-protein coupled receptor for asthma susceptibility
  • G-protein coupled receptor PGR14
  • GPR154
  • GPRA
  • PGR14
Gene NameNPSR1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001888|Neuropeptide S receptor
MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLF
VFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLV
CRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIP
TLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIK
SKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFN
LLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERH
EMQILSKPEFI
Number of residues371
Molecular Weight42686.28
Theoretical pI8.44
GO Classification
Functions
  • vasopressin receptor activity
  • neuropeptide receptor activity
Processes
  • neuropeptide signaling pathway
  • positive regulation of release of sequestered calcium ion into cytosol
  • righting reflex
  • positive regulation of ERK1 and ERK2 cascade
  • eating behavior
  • negative regulation of defecation
  • negative regulation of eating behavior
Components
  • cytoplasm
  • plasma membrane
  • integral component of plasma membrane
General FunctionVasopressin receptor activity
Specific FunctionG-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases.
Pfam Domain Function
Transmembrane Regions53-73 83-103 124-144 165-185 213-233 276-296 313-333
GenBank Protein ID34596864
UniProtKB IDQ6W5P4
UniProtKB Entry NameNPSR1_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0010667|Neuropeptide S receptor (NPSR1)
ATGCCAGCCAACTTCACAGAGGGCAGCTTCGATTCCAGTGGGACCGGGCAGACGCTGGAT
TCTTCCCCAGTGGCTTGCACTGAAACAGTGACTTTTACTGAAGTGGTGGAAGGAAAGGAA
TGGGGTTCCTTCTACTACTCCTTTAAGACTGAGCAATTGATAACTCTGTGGGTCCTCTTT
GTTTTTACCATTGTTGGAAACTCCGTTGTGCTTTTTTCCACATGGAGGAGAAAGAAGAAG
TCAAGAATGACCTTCTTTGTGACTCAGCTGGCCATCACAGATATTAATTGGCGATTCACT
GGAGACTTCACGGCACCTGACCTGGTTTGCCGAGTGGTCCGCTATTTGCAGGTTGTGCTG
CTCTACGCCTCTACCTACGTCCTGGTGTCCCTCAGCATAGACAGATACCATGCCATCGTC
TACCCCATGAAGTTCCTTCAAGGAGAAAAGCAAGCCAGGGTCCTCATTGTGATCGCCTGG
AGCCTGTCTTTTCTGTTCTCCATTCCCACCCTGATCATATTTGGGAAGAGGACACTGTCC
AACGGTGAAGTGCAGTGCTGGGCCCTGTGGCCTGACGACTCCTACTGGACCCCATACATG
ACCATCGTGGCCTTCCTGGTGTACTTCATCCCTCTGACAATCATCAGCATCATGTATGGC
ATTGTGATCCGAACTATTTGGATTAAAAGCAAAACCTACGAAACAGTGATTTCCAACTGC
TCAGATGGGAAACTGTGCAGCAGCTATAACCGAGGACTCATCTCAAAGGCAAAAATCAAG
GCTATCAAGTATAGCATCATCATCATTCTTGCCTTCATCTGCTGTTGGAGTCCATACTTC
CTGTTTGACATTTTGGACAATTTCAACCTCCTTCCAGACACCCAGGAGCGTTTCTATGCC
TCTGTGATCATTCAGAACCTGCCAGCATTGAATAGTGCCATCAACCCCCTCATCTACTGT
GTCTTCAGCAGCTCCATCTCTTTCCCCTGCAGGGTCATCCGTCTCCGTCAGCTCCAGGAG
GCTGCGCTAATGCTCTGCCCTCAACGAGAGAACTGGAAGGGTACTTGGCCAGGTGTACCT
TCCTGGGCTCTTCCAAGGTGA
GenBank Gene IDAY310326
GeneCard IDNot Available
GenAtlas IDNPSR1
HGNC IDHGNC:23631
Chromosome Location7
Locus7p14.3
References
  1. Laitinen T, Polvi A, Rydman P, Vendelin J, Pulkkinen V, Salmikangas P, Makela S, Rehn M, Pirskanen A, Rautanen A, Zucchelli M, Gullsten H, Leino M, Alenius H, Petays T, Haahtela T, Laitinen A, Laprise C, Hudson TJ, Laitinen LA, Kere J: Characterization of a common susceptibility locus for asthma-related traits. Science. 2004 Apr 9;304(5668):300-4. 15073379
  2. Vendelin J, Pulkkinen V, Rehn M, Pirskanen A, Raisanen-Sokolowski A, Laitinen A, Laitinen LA, Kere J, Laitinen T: Characterization of GPRA, a novel G protein-coupled receptor related to asthma. Am J Respir Cell Mol Biol. 2005 Sep;33(3):262-70. Epub 2005 Jun 9. 15947423
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  5. Xu YL, Reinscheid RK, Huitron-Resendiz S, Clark SD, Wang Z, Lin SH, Brucher FA, Zeng J, Ly NK, Henriksen SJ, de Lecea L, Civelli O: Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. Neuron. 2004 Aug 19;43(4):487-97. 15312648
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