NameHistone H3.3C
Synonyms
  • Histone H3.5
Gene NameH3F3C
OrganismHuman
Amino acid sequence
>lcl|BSEQ0020832|Histone H3.3C
MARTKQTARKSTGGKAPRKQLATKAARKSTPSTCGVKPHRYRPGTVALREIRRYQKSTEL
LIRKLPFQRLVREIAQDFNTDLRFQSAAVGALQEASEAYLVGLLEDTNLCAIHAKRVTIM
PKDIQLARRIRGERA
Number of residues135
Molecular Weight15213.57
Theoretical pINot Available
GO Classification
Functions
  • nucleosomal DNA binding
Processes
  • positive regulation of cell growth
Components
  • nuclear euchromatin
  • nucleosome
General FunctionNucleosomal dna binding
Specific FunctionCore component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ6NXT2
UniProtKB Entry NameH3C_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0020833|Histone H3.3C (H3F3C)
ATGGCCCGAACCAAGCAGACTGCTCGTAAATCCACCGGTGGGAAAGCCCCCCGCAAACAG
CTGGCCACGAAAGCTGCCAGGAAAAGCACCCCCTCTACCTGCGGGGTGAAGCCTCATCGC
TACAGGCCTGGGACCGTGGCGCTTCGAGAGATTCGTCGTTATCAGAAGTCGACCGAGCTG
CTCATCCGGAAGCTGCCCTTCCAGAGGTTGGTGAGGGAGATCGCGCAGGATTTCAACACT
GACCTGAGGTTTCAGAGCGCAGCCGTCGGTGCGCTGCAGGAGGCTAGCGAAGCGTACCTG
GTGGGTCTGTTGGAAGATACTAACCTGTGTGCCATCCACGCTAAGAGAGTCACCATCATG
CCCAAAGACATCCAGTTGGCTCGCCGGATACGGGGAGAGAGAGCTTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:33164
Chromosome Location12
LocusNot Available
References
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