NameDNA oxidative demethylase ALKBH2
Synonyms
  • 1.14.11.33
  • ABH2
  • Alkylated DNA repair protein alkB homolog 2
  • Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2
  • Oxy DC1
Gene NameALKBH2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004327|DNA oxidative demethylase ALKBH2
MDRFLVKGAQGGLLRKQEEQEPTGEEPAVLGGDKESTRKRPRREAPGNGGHSAGPSWRHI
RAEGLDCSYTVLFGKAEADEIFQELEKEVEYFTGALARVQVFGKWHSVPRKQATYGDAGL
TYTFSGLTLSPKPWIPVLERIRDHVSGVTGQTFNFVLINRYKDGCDHIGEHRDDERELAP
GSPIASVSFGACRDFVFRHKDSRGKSPSRRVAVVRLPLAHGSLLMMNHPTNTHWYHSLPV
RKKVLAPRVNLTFRKILLTKK
Number of residues261
Molecular Weight29322.22
Theoretical pI10.22
GO Classification
Functions
  • ferrous iron binding
  • cytosine C-5 DNA demethylase activity
  • DNA-N1-methyladenine dioxygenase activity
Processes
  • DNA repair
  • DNA dealkylation involved in DNA repair
  • DNA demethylation
  • oxidative demethylation
  • oxidative DNA demethylation
Components
  • microtubule cytoskeleton
  • nucleus
  • nucleoplasm
General FunctionFerrous iron binding
Specific FunctionDioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID53988530
UniProtKB IDQ6NS38
UniProtKB Entry NameALKB2_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0020600|DNA oxidative demethylase ALKBH2 (ALKBH2)
ATGGACAGATTCCTGGTGAAAGGGGCTCAAGGGGGCCTTTTGAGGAAGCAGGAGGAGCAA
GAGCCAACTGGAGAAGAGCCAGCTGTGTTGGGAGGAGACAAAGAAAGCACAAGGAAGAGG
CCCAGGAGAGAGGCCCCAGGGAATGGAGGCCACTCAGCAGGCCCTAGCTGGCGGCACATT
CGGGCTGAGGGCCTGGACTGCAGTTACACAGTCCTGTTTGGCAAAGCTGAGGCAGATGAG
ATTTTCCAAGAGTTGGAGAAAGAAGTAGAATATTTTACAGGAGCACTGGCCAGAGTCCAG
GTATTCGGGAAGTGGCACAGTGTGCCCAGGAAGCAGGCAACGTATGGCGACGCTGGGCTG
ACCTACACATTTTCAGGCCTCACGCTGTCTCCAAAGCCCTGGATCCCAGTTCTAGAGCGC
ATCCGGGATCACGTCTCTGGGGTGACTGGACAGACCTTCAACTTTGTGCTCATCAACAGG
TATAAAGATGGCTGTGACCACATCGGGGAGCACCGAGATGATGAAAGAGAACTGGCCCCT
GGGAGCCCCATTGCCTCTGTCTCCTTCGGTGCCTGCAGAGACTTTGTCTTCCGGCATAAG
GATTCCCGTGGGAAAAGCCCCTCCAGGAGGGTGGCGGTGGTCAGGCTGCCGCTGGCCCAC
GGGAGCTTACTAATGATGAACCACCCGACCAACACGCACTGGTACCACAGTCTTCCCGTG
AGAAAGAAGGTTCTGGCTCCACGGGTGAATCTGACTTTTCGTAAAATTTTGCTTACTAAA
AAATAA
GenBank Gene IDAY754389
GeneCard IDNot Available
GenAtlas IDALKBH2
HGNC IDHGNC:32487
Chromosome Location12
Locus12q24.11
References
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