Lysine-specific demethylase 4D

NameLysine-specific demethylase 4D
Synonyms
  • 1.14.11.-
  • JHDM3D
  • JmjC domain-containing histone demethylation protein 3D
  • JMJD2D
  • Jumonji domain-containing protein 2D
Gene NameKDM4D
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037292|Lysine-specific demethylase 4D
METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKAR
ETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFED
LERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYL
YFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGA
FLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRW
IDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQDRAVVDHMEPRVPASQELST
QKEVQLPRRAALGLRQLPSHWARHSPWPMAARSGTRCHTLVCSSLPRRSAVSGTATQPRA
AAVHSSKKPSSTPSSTPGPSAQIIHPSNGRRGRGRPPQKLRAQELTLQTPAKRPLLAGTT
CTASGPEPEPLPEDGALMDKPVPLSPGLQHPVKASGCSWAPVP
Number of residues523
Molecular Weight58602.32
Theoretical pINot Available
GO Classification
Functions
  • dioxygenase activity
  • histone demethylase activity (H3-K9 specific)
  • metal ion binding
Processes
  • histone H3-K9 demethylation
  • positive regulation of chromatin binding
  • positive regulation of double-strand break repair via nonhomologous end joining
  • regulation of protein phosphorylation
  • double-strand break repair via homologous recombination
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • chromatin organization
  • cellular response to ionizing radiation
Components
  • site of double-strand break
  • nucleoplasm
  • blood microparticle
General FunctionMetal ion binding
Specific FunctionHistone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ6B0I6
UniProtKB Entry NameKDM4D_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013962|Lysine-specific demethylase 4D (KDM4D)
ATGGAAACTATGAAGTCTAAGGCCAACTGTGCCCAGAATCCAAATTGTAACATAATGATA
TTTCATCCAACCAAAGAAGAGTTTAATGATTTTGATAAATATATTGCTTACATGGAATCC
CAAGGTGCACACAGAGCTGGCTTGGCTAAGATAATTCCACCCAAAGAATGGAAAGCCAGA
GAGACCTATGATAATATCAGTGAAATCTTAATAGCCACTCCCCTCCAGCAGGTGGCCTCT
GGGCGGGCAGGGGTGTTTACTCAATACCATAAAAAAAAGAAAGCCATGACTGTGGGGGAG
TATCGCCATTTGGCAAACAGTAAAAAATATCAGACTCCACCACACCAGAATTTCGAAGAT
TTGGAGCGAAAATACTGGAAGAACCGCATCTATAATTCACCGATTTATGGTGCTGACATC
AGTGGCTCCTTGTTTGATGAAAACACTAAACAATGGAATCTTGGGCACCTGGGAACAATT
CAGGACCTGCTGGAAAAGGAATGTGGGGTTGTCATAGAAGGCGTCAATACACCCTACTTG
TACTTTGGCATGTGGAAAACCACGTTTGCTTGGCATACAGAGGACATGGACCTTTACAGC
ATCAACTACCTGCACCTTGGGGAGCCCAAAACTTGGTATGTGGTGCCCCCAGAACATGGC
CAGCGCCTGGAACGCCTGGCCAGGGAGCTCTTCCCAGGCAGTTCCCGGGGTTGTGGGGCC
TTCCTGCGGCACAAGGTGGCCCTCATCTCGCCTACAGTTCTCAAGGAAAATGGGATTCCC
TTCAATCGCATAACTCAGGAGGCTGGAGAGTTCATGGTGACCTTTCCCTATGGCTACCAT
GCTGGCTTCAACCATGGTTTCAACTGCGCAGAGGCCATCAATTTTGCCACTCCGCGATGG
ATTGATTATGGCAAAATGGCCTCCCAGTGTAGCTGTGGGGAGGCAAGGGTGACCTTTTCC
ATGGATGCCTTCGTGCGCATCCTGCAACCTGAACGCTATGACCTGTGGAAACGTGGGCAA
GACCGGGCAGTTGTGGACCACATGGAGCCCAGGGTACCAGCCAGCCAAGAGCTGAGCACC
CAGAAGGAAGTCCAGTTACCCAGGAGAGCAGCGCTGGGCCTGAGACAACTCCCTTCCCAC
TGGGCCCGGCATTCCCCTTGGCCTATGGCTGCCCGCAGTGGGACACGGTGCCACACCCTT
GTGTGCTCTTCACTCCCACGCCGATCTGCAGTTAGTGGCACTGCTACGCAGCCCCGGGCT
GCTGCTGTCCACAGCTCTAAGAAGCCCAGCTCAACTCCATCATCCACCCCTGGTCCATCT
GCACAGATTATCCACCCGTCAAATGGCAGACGTGGTCGTGGTCGCCCTCCTCAGAAACTG
AGAGCTCAGGAGCTGACCCTCCAGACTCCAGCCAAGAGGCCCCTCTTGGCGGGCACAACA
TGCACAGCTTCGGGCCCAGAACCTGAGCCCCTACCTGAGGATGGGGCTTTGATGGACAAG
CCTGTACCACTGAGCCCAGGGCTCCAGCATCCTGTCAAGGCTTCTGGGTGCAGCTGGGCC
CCTGTGCCCTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:25498
Chromosome Location11
LocusNot Available
References
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