NameGlycoprotein endo-alpha-1,2-mannosidase
Synonyms
  • 3.2.1.130
  • Endo-alpha mannosidase
  • Mandaselin
Gene NameMANEA
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009198|Glycoprotein endo-alpha-1,2-mannosidase
MAKFRRRTCIILALFILFIFSLMMGLKMLRPNTATFGAPFGLDLLPELHQRTIHLGKNFD
FQKSDRINSETNTKNLKSVEITMKPSKASELNLDELPPLNNYLHVFYYSWYGNPQFDGKY
IHWNHPVLEHWDPRIAKNYPQGRHNPPDDIGSSFYPELGSYSSRDPSVIETHMRQMRSAS
IGVLALSWYPPDVNDENGEPTDNLVPTILDKAHKYNLKVTFHIEPYSNRDDQNMYKNVKY
IIDKYGNHPAFYRYKTKTGNALPMFYVYDSYITKPEKWANLLTTSGSRSIRNSPYDGLFI
ALLVEEKHKYDILQSGFDGIYTYFATNGFTYGSSHQNWASLKLFCDKYNLIFIPSVGPGY
IDTSIRPWNTQNTRNRINGKYYEIGLSAALQTRPSLISITSFNEWHEGTQIEKAVPKRTS
NTVYLDYRPHKPGLYLELTRKWSEKYSKERATYALDRQLPVS
Number of residues462
Molecular Weight53670.425
Theoretical pINot Available
GO Classification
Functions
  • glycoprotein endo-alpha-1,2-mannosidase activity
Processes
  • post-translational protein modification
  • protein N-linked glycosylation via asparagine
  • cellular protein metabolic process
Components
  • Golgi apparatus
  • integral component of membrane
  • Golgi membrane
General FunctionGlycoprotein endo-alpha-1,2-mannosidase activity
Specific FunctionNot Available
Pfam Domain Function
Transmembrane Regions9-29
GenBank Protein IDNot Available
UniProtKB IDQ5SRI9
UniProtKB Entry NameMANEA_HUMAN
Cellular LocationGolgi apparatus membrane
Gene sequence
>lcl|BSEQ0013667|Glycoprotein endo-alpha-1,2-mannosidase (MANEA)
ATGGCAAAGTTTCGGAGAAGGACTTGCATCATTTTGGCACTTTTTATTCTATTTATTTTC
TCTCTGATGATGGGTTTAAAAATGCTGAGACCAAATACAGCTACTTTTGGAGCTCCTTTT
GGACTTGACCTTCTTCCAGAACTTCATCAACGAACTATTCATTTGGGGAAAAATTTTGAT
TTCCAAAAGAGTGACAGAATCAACAGTGAAACAAATACCAAGAATTTAAAAAGTGTTGAA
ATCACTATGAAACCTTCCAAAGCCTCTGAACTTAACTTGGATGAACTACCACCTCTGAAC
AATTATCTACATGTATTTTATTACAGTTGGTATGGAAATCCACAATTTGATGGTAAATAT
ATACATTGGAATCATCCAGTGTTAGAGCATTGGGACCCTAGAATAGCCAAGAATTATCCA
CAAGGGAGACACAACCCTCCAGATGACATTGGCTCCAGCTTTTATCCTGAATTGGGAAGT
TACAGTTCTCGGGATCCTTCTGTCATAGAAACTCACATGAGACAAATGCGCTCAGCTTCA
ATTGGTGTACTAGCCCTCTCTTGGTACCCACCTGATGTAAATGATGAAAATGGAGAACCT
ACTGATAACTTGGTACCCACTATTTTGGATAAAGCTCATAAATATAACCTAAAGGTTACT
TTTCACATAGAACCATATAGCAATCGAGATGATCAAAACATGTACAAAAATGTCAAGTAT
ATTATAGACAAATATGGAAATCATCCGGCCTTTTACAGGTACAAGACGAAGACTGGCAAT
GCTCTTCCTATGTTTTATGTCTATGATTCCTATATTACCAAGCCTGAAAAATGGGCCAAT
CTGTTAACCACCTCAGGGTCTCGGAGTATTCGCAATTCTCCTTATGATGGACTGTTTATT
GCCCTTCTGGTAGAAGAAAAACATAAGTATGATATTCTTCAAAGTGGTTTTGATGGAATT
TACACATATTTTGCCACAAATGGCTTTACTTATGGCTCATCACATCAGAATTGGGCTAGC
CTAAAATTATTTTGTGATAAATACAACTTAATATTTATCCCAAGTGTGGGCCCAGGATAC
ATAGATACCAGCATCCGTCCATGGAACACGCAAAACACTCGGAACCGAATCAATGGGAAG
TATTATGAAATTGGTCTGAGTGCCGCACTTCAGACACGCCCCAGCTTAATTTCTATCACC
TCTTTTAATGAGTGGCATGAAGGAACTCAGATTGAAAAAGCTGTTCCCAAAAGAACCAGT
AATACAGTGTACCTAGATTACCGTCCTCATAAACCAGGTCTTTACCTAGAACTGACTCGC
AAGTGGTCTGAAAAATACAGTAAGGAAAGAGCAACTTATGCATTAGATCGCCAGCTGCCT
GTTTCTTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:21072
Chromosome Location6
LocusNot Available
References
  1. Hardt B, Volker C, Mundt S, Salska-Navarro M, Hauptmann M, Bause E: Human endo-alpha1,2-mannosidase is a Golgi-resident type II membrane protein. Biochimie. 2005 Feb;87(2):169-79. 15760709
  2. Hamilton SR, Li H, Wischnewski H, Prasad A, Kerley-Hamilton JS, Mitchell T, Walling AJ, Davidson RC, Wildt S, Gerngross TU: Intact {alpha}-1,2-endomannosidase is a typical type II membrane protein. Glycobiology. 2005 Jun;15(6):615-24. Epub 2005 Jan 26. 15677381
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