Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

NameGuanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
Synonyms
  • Adenylate cyclase-stimulating G alpha protein
  • Extra large alphas protein
  • GNAS1
  • XLalphas
Gene NameGNAS
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009110|Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
MGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIP
VENDGEACGPPEVSRPNFQVLNPAFREAGAHGSYSPPPEEAMPFEAEQPSLGGFWPTLEQ
PGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRGCSQLLLQ
VPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPP
GLSRVIAQVDGSSQFAAVAASSAVRLTPAANAPPLWVPGAIGSPSQEAVRPPSNFTGSSP
WMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPPVEEEAAE
MEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADP
DSGAFAADPDSGAAPAAPADPDSGAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAPAAA
ETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSPEIQAADP
PTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRR
RKPQRNLLRNFLVQAFGGCFGRSESPQPKASRSLKVKKVPLAEKRRQMRKEALEKRAQKR
AEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDP
QAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNV
PDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDL
LRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVI
REDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFAR
YTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFN
DCRDIIQRMHLRQYELL
Number of residues1037
Molecular Weight111023.29
Theoretical pINot Available
GO Classification
Functions
  • beta-2 adrenergic receptor binding
  • corticotropin-releasing hormone receptor 1 binding
  • signal transducer activity
  • mu-type opioid receptor binding
  • GTP binding
  • GTPase activity
  • metal ion binding
  • insulin-like growth factor receptor binding
  • D1 dopamine receptor binding
  • ionotropic glutamate receptor binding
  • G-protein beta/gamma-subunit complex binding
Processes
  • platelet aggregation
  • adenylate cyclase-activating dopamine receptor signaling pathway
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway
  • genetic imprinting
  • bone development
  • post-embryonic body morphogenesis
  • tissue homeostasis
  • response to drug
  • DNA methylation
  • positive regulation of osteoblast differentiation
  • embryonic hindlimb morphogenesis
  • cartilage development
  • developmental growth
  • embryonic cranial skeleton morphogenesis
  • endochondral ossification
  • positive regulation of osteoclast differentiation
  • multicellular organism growth
  • hair follicle placode formation
  • energy reserve metabolic process
  • sensory perception of chemical stimulus
  • cognition
Components
  • membrane
  • heterotrimeric G-protein complex
  • cytosol
  • extracellular exosome
  • dendrite
General FunctionSignal transducer activity
Specific FunctionGuanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ5JWF2
UniProtKB Entry NameGNAS1_HUMAN
Cellular LocationCell membrane
Gene sequenceNot Available
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:4392
Chromosome LocationNot Available
LocusNot Available
References
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