T3DB: Chromosome-associated kinesin KIF4B

Name	Chromosome-associated kinesin KIF4B
Synonyms	Chromokinesin-B
Gene Name	KIF4B
Organism	Human
Amino acid sequence	>lcl\|BSEQ0020858\|Chromosome-associated kinesin KIF4B MKEEVKGIPVRVALRCRPLVPKEISEGCQMCLSFVPGETQVVVGTDKSFTYDFVFDPCTE QEEVFNKAVAPLIKGIFKGYNATVLAYGQTGSGKTYSMGGAYTAEQENEPTVGIIPRVIQ LLFKEIDKKSDFEFTLKVSYLEIYNEEILDLLCPSREKAQINIREDPKEGIKIVGLTEKT VLVALDTVSCLEQGNNSRTVASTAMNSQSSRSHAIFTISIEQRKKSDKNCSFRSKLHLVD LAGSERQKKTKAEGDRLKEGININRGLLCLGNVISALGDDKKGSFVPYRDSKLTRLLQDS LGGNSHTLMIACVSPADSNLEETLSTLRYADRARKIKNKPIVNIDPHTAELNHLKQQVQQ LQVLLLQAHGGTLPGSINAEPSENLQSLMEKNQSLVEENEKLSRCLSKAAGQTAQMLERI ILTEQVNEKLNAKLEELRQHVACKLDLQKLVETLEDQELKENVEIICNLQQLITQLSDET VACTAAAIDTAVEEEAQVETSPETSRSSDAFTTQHALHQAQMSKEVVELNNALALKEALV RKMTQNDNQLQPIQFQYQDNIKNLELEVINLQKEKEELVRELQTAKKNVNQAKLSEHRHK LLQELEGQIADLKKKLNEQSKLLKLKESTERTVSKLNQEIWMMKNQRVQLMRQMKEDAEK FRQWKQKKDKEVIQLKERDRKRQYELLKLERNFQKQSSVLRRKTEEAAAANKRLKDALQK QREVTDKRKETQSHGKEGIAARVRNWLGNEIEVMVSTEEAKRHLNDLLEDRKILAQDVVQ LKEKKESRENPPPKLRKCTFSLSEVHGQVLESEDCITKQIESLETEMELRSAQIADLQQK LLDAESEDRPKQCWENIATILEAKCALKYLIGELVSSKIHVTKLENSLRQSKASCADMQK MLFEEQNHFSEIETELQAELVRMEQQHQEKVLYLVSQLQESQMAEKQLEKSASEKEQQLV STLQCQDEELEKMREVCEQNQQLLQENEIIKQKLILLQVASRQKHLPNDTLLSPDSSFEY IPPKPKPSRVKEKFLEQSMDIEDLKYCSEHSVNEHEDGDGDGDSDEGDDEEWKPTKLVKV SRKNIQGCSCKGWCGNKQCGCRKQKSDCGVDCSCDPTKCRNRQQGKDSLGTVEQTQDSEG SFKLEDPTEVTPGLSFFNPVCATPNSKILKEMCDMEQVLSKKTAPAPSPFDLPESKHGAT EYQQNKPPGKKKKRALASNTSFFSGCSPIEEEAH
Number of residues	1234
Molecular Weight	140034.185
Theoretical pI	Not Available
GO Classification	Functions ATP binding DNA binding ATPase activity microtubule motor activity Processes mitotic spindle midzone assembly mitotic cytokinesis microtubule-based movement blood coagulation axon guidance antigen processing and presentation of exogenous peptide antigen via MHC class II Components microtubule cytosol nucleoplasm nuclear matrix kinesin complex
General Function	Microtubule motor activity
Specific Function	Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity).
Pfam Domain Function	Kinesin (PF00225 )
Transmembrane Regions	Not Available
GenBank Protein ID	Not Available
UniProtKB ID	Q2VIQ3
UniProtKB Entry Name	KIF4B_HUMAN
Cellular Location	Nucleus matrix
Gene sequence	>lcl\|BSEQ0020859\|Chromosome-associated kinesin KIF4B (KIF4B) ATGAAGGAAGAGGTGAAGGGAATTCCTGTAAGAGTGGCACTGCGTTGTCGCCCTCTGGTC CCCAAAGAGATTAGCGAGGGCTGCCAGATGTGCCTTTCCTTCGTGCCCGGGGAGACTCAG GTGGTGGTTGGTACTGATAAATCCTTCACCTACGATTTTGTGTTTGACCCCTGTACTGAG CAGGAAGAAGTCTTCAATAAAGCAGTAGCGCCGCTCATAAAAGGCATATTTAAAGGATAT AATGCAACGGTCCTGGCCTATGGGCAGACTGGCTCTGGAAAAACCTATTCAATGGGAGGT GCATACACTGCGGAGCAGGAGAATGAACCAACAGTTGGCATTATTCCTAGGGTAATACAA CTGCTCTTCAAAGAAATTGATAAAAAGAGTGACTTTGAATTTACTCTGAAAGTGTCTTAC TTAGAGATTTACAATGAAGAAATTTTGGATCTTCTATGCCCATCTCGTGAGAAAGCTCAA ATAAATATACGGGAGGATCCTAAGGAAGGCATAAAGATTGTGGGACTCACTGAGAAGACT GTTTTAGTTGCCTTGGATACTGTTTCCTGTTTGGAGCAGGGCAACAACTCTAGGACTGTG GCCTCCACAGCTATGAACTCCCAGTCGTCCCGATCTCATGCCATCTTTACAATCTCCATA GAGCAAAGAAAGAAAAGTGACAAGAATTGCAGCTTTCGCTCCAAGCTGCATCTTGTAGAT CTCGCTGGATCAGAAAGACAGAAGAAAACCAAGGCTGAAGGGGATCGTCTAAAAGAGGGT ATTAATATTAACCGAGGCCTCCTATGCTTGGGAAATGTAATCAGTGCTCTTGGAGATGAC AAAAAGGGTAGCTTTGTGCCCTACAGAGATTCCAAGTTAACTCGACTGCTGCAAGATTCT CTAGGAGGTAACAGCCACACTCTTATGATAGCCTGTGTGAGTCCTGCTGACTCCAATCTA GAGGAAACATTAAGTACCCTTCGCTATGCTGACAGAGCAAGAAAAATCAAGAACAAACCT ATTGTTAATATTGATCCCCACACAGCTGAACTTAATCATCTAAAGCAACAGGTACAACAG CTACAAGTCTTGTTGCTACAAGCCCATGGAGGTACCCTGCCTGGATCTATAAATGCAGAA CCATCAGAGAATCTACAATCCCTGATGGAGAAGAATCAGTCCCTGGTAGAGGAGAATGAA AAATTAAGTCGTTGTCTGAGCAAGGCAGCTGGTCAGACAGCCCAGATGTTGGAGAGGATC ATTTTGACAGAGCAAGTGAATGAAAAACTGAACGCCAAGCTAGAAGAGCTCAGGCAGCAT GTGGCCTGCAAGCTGGATCTTCAAAAGCTAGTGGAGACTTTGGAAGACCAGGAATTGAAA GAAAATGTAGAGATAATTTGTAACCTGCAGCAACTGATTACCCAGTTATCAGATGAAACT GTTGCTTGCACGGCTGCAGCCATTGATACTGCGGTAGAAGAAGAAGCTCAAGTGGAAACC AGTCCAGAGACAAGCAGGTCTTCTGACGCTTTTACCACTCAGCATGCTCTCCATCAAGCT CAGATGTCTAAGGAGGTGGTTGAGTTGAATAACGCCCTTGCACTGAAAGAGGCCCTAGTT AGGAAGATGACTCAGAACGACAACCAACTACAGCCCATTCAGTTTCAATACCAGGATAAC ATAAAAAATCTAGAATTAGAAGTCATCAATCTGCAAAAGGAAAAGGAAGAATTGGTTCGT GAACTTCAGACAGCAAAGAAGAATGTCAACCAAGCCAAGCTGAGTGAGCACCGCCACAAA CTTCTCCAGGAGCTGGAGGGTCAAATAGCTGATCTGAAGAAGAAACTGAATGAGCAGTCC AAACTTCTGAAACTAAAGGAATCCACAGAGCGTACTGTCTCCAAGCTGAACCAAGAGATA TGGATGATGAAAAACCAGCGGGTACAGTTAATGCGTCAAATGAAAGAGGATGCTGAGAAG TTTAGACAATGGAAGCAGAAAAAAGACAAAGAAGTAATACAGTTGAAAGAACGAGACCGT AAGAGGCAATATGAGCTGCTCAAACTTGAAAGAAACTTCCAGAAACAATCCAGTGTGCTC AGACGTAAAACGGAAGAGGCAGCAGCTGCCAACAAGCGACTCAAGGATGCTCTCCAGAAA CAACGAGAGGTCACAGATAAGCGGAAAGAGACTCAGAGCCATGGAAAGGAAGGTATTGCA GCTCGAGTGAGGAATTGGCTTGGAAATGAAATTGAGGTTATGGTCAGTACTGAGGAAGCC AAACGCCATCTGAATGACCTCCTTGAAGACAGAAAGATCCTGGCTCAGGATGTGGTTCAA CTCAAAGAAAAAAAGGAATCTCGGGAGAATCCACCTCCTAAACTCCGGAAGTGTACATTC TCCCTTTCTGAGGTGCATGGTCAAGTTTTGGAGTCAGAAGATTGTATTACAAAACAGATT GAAAGCCTAGAGACTGAAATGGAACTCAGGAGTGCTCAGATTGCTGACCTACAGCAGAAG CTGCTGGATGCAGAAAGTGAAGATAGGCCAAAACAATGCTGGGAGAATATTGCCACCATT CTGGAAGCCAAGTGTGCCCTGAAATATTTGATTGGAGAGCTGGTCTCCTCCAAAATACAT GTCACCAAACTTGAAAACAGCCTGAGACAGAGCAAGGCCAGCTGTGCTGACATGCAGAAG ATGCTATTTGAGGAACAAAATCATTTTTCTGAGATAGAGACAGAGTTACAAGCTGAGCTG GTCAGAATGGAGCAACAGCACCAAGAGAAGGTGCTATACCTTGTCAGCCAGCTGCAGGAA AGCCAAATGGCAGAGAAGCAGTTAGAGAAATCAGCCAGTGAAAAGGAACAACAGCTGGTG AGCACACTGCAGTGTCAGGATGAAGAACTTGAGAAGATGCGAGAAGTGTGTGAGCAAAAT CAGCAGCTTCTCCAAGAGAATGAAATCATCAAGCAGAAACTGATCCTCCTCCAGGTAGCC AGCAGACAGAAACATCTTCCTAATGATACCCTTCTATCTCCAGACTCTTCTTTTGAATAT ATCCCACCTAAGCCAAAACCTTCTCGTGTTAAAGAAAAGTTTCTGGAGCAAAGCATGGAC ATCGAGGATCTAAAATATTGTTCAGAGCATTCTGTGAATGAGCATGAAGATGGTGATGGT GATGGCGACAGTGATGAGGGGGATGATGAGGAATGGAAGCCAACAAAATTAGTCAAGGTG TCCAGGAAGAACATCCAAGGGTGTTCCTGCAAGGGCTGGTGTGGGAACAAGCAGTGTGGG TGCAGGAAGCAAAAGTCAGACTGTGGTGTGGACTGTAGCTGTGACCCCACAAAGTGTCGG AACCGCCAGCAAGGCAAGGATAGCTTGGGCACTGTTGAACAGACCCAGGATTCCGAAGGC TCCTTCAAACTGGAGGATCCTACCGAGGTGACCCCAGGATTGAGCTTCTTTAACCCTGTC TGTGCCACCCCCAATAGCAAGATCCTGAAAGAGATGTGTGACATGGAGCAGGTGCTGTCA AAGAAGACTGCTCCAGCTCCCTCCCCTTTTGACCTCCCAGAGTCGAAACATGGAGCAACA GAATACCAACAAAATAAGCCTCCAGGGAAGAAAAAGAAACGAGCTCTGGCTAGCAACACC AGCTTCTTCTCTGGCTGCTCCCCTATCGAAGAAGAGGCCCACTGA
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:6322
Chromosome Location	5
Locus	Not Available
References	Oh S, Hahn H, Torrey TA, Shin H, Choi W, Lee YM, Morse HC, Kim W: Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein. Biochim Biophys Acta. 2000 Sep 7;1493(1-2):219-24. 10978527 Schmutz J, Martin J, Terry A, Couronne O, Grimwood J, Lowry S, Gordon LA, Scott D, Xie G, Huang W, Hellsten U, Tran-Gyamfi M, She X, Prabhakar S, Aerts A, Altherr M, Bajorek E, Black S, Branscomb E, Caoile C, Challacombe JF, Chan YM, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Lopez F, Lou Y, Martinez D, Medina C, Morgan J, Nandkeshwar R, Noonan JP, Pitluck S, Pollard M, Predki P, Priest J, Ramirez L, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wheeler J, Wu K, Yang J, Dickson M, Cheng JF, Eichler EE, Olsen A, Pennacchio LA, Rokhsar DS, Richardson P, Lucas SM, Myers RM, Rubin EM: The DNA sequence and comparative analysis of human chromosome 5. Nature. 2004 Sep 16;431(7006):268-74. 15372022 Marques AC, Dupanloup I, Vinckenbosch N, Reymond A, Kaessmann H: Emergence of young human genes after a burst of retroposition in primates. PLoS Biol. 2005 Nov;3(11):e357. Epub 2005 Oct 11. 16201836