Cysteine dioxygenase type 1

NameCysteine dioxygenase type 1
Synonyms
  • 1.13.11.20
  • CDO
  • CDO-I
  • Cysteine dioxygenase type I
Gene NameCDO1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0016136|Cysteine dioxygenase type 1
MEQTEVLKPRTLADLIRILHQLFAGDEVNVEEVQAIMEAYESDPTEWAMYAKFDQYRYTR
NLVDQGNGKFNLMILCWGEGHGSSIHDHTNSHCFLKMLQGNLKETLFAWPDKKSNEMVKK
SERVLRENQCAYINDSIGLHRVENISHTEPAVSLHLYSPPFDTCHAFDQRTGHKNKVTMT
FHSKFGIRTPNATSGSLENN
Number of residues200
Molecular Weight22971.745
Theoretical pI6.58
GO Classification
Functions
  • ferrous iron binding
  • cysteine dioxygenase activity
Processes
  • sulfur amino acid biosynthetic process
  • lactation
  • cellular nitrogen compound metabolic process
  • small molecule metabolic process
  • response to cAMP
  • oxidation-reduction process
  • response to glucocorticoid
  • sulfur amino acid metabolic process
  • response to amino acid
  • response to ethanol
  • L-cysteine catabolic process
  • cysteine metabolic process
  • response to glucagon
  • sulfur amino acid catabolic process
  • taurine biosynthetic process
  • inflammatory response
Components
  • cytosol
General FunctionFerrous iron binding
Specific FunctionInitiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID467561
UniProtKB IDQ16878
UniProtKB Entry NameCDO1_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0016137|Cysteine dioxygenase type 1 (CDO1)
ATGGAACAGACCGAAGTGCTGAAGCCACGGACCCTGGCTGATCTGATCCGCATCCTGCAC
CAGCTCTTTGCCGGCGATGAGGTCAATGTAGAGGAGGTGCAGGCCATCATGGAAGCCTAC
GAGAGCGACCCCACCGAGTGGGCAATGTACGCCAAGTTCGACCAGTACAGGTATACCCGA
AATCTTGTGGATCAAGGAAATGGAAAATTTAATCTGATGATTCTCTGTTGGGGTGAAGGA
CATGGCAGCAGTATTCATGATCATACCAACTCCCACTGCTTTCTGAAGATGCTACAGGGA
AATCTAAAGGAGACATTATTTGCCTGGCCTGACAAAAAATCCAATGAGATGGTCAAGAAG
TCTGAAAGAGTCTTGAGGGAAAACCAGTGTGCCTACATCAATGATTCCATTGGCTTACAT
CGAGTAGAGAACATCAGCCATACGGAACCTGCTGTGAGCCTTCACTTGTACAGTCCACCT
TTTGATACATGCCATGCCTTTGATCAAAGAACAGGACATAAAAACAAAGTCACAATGACA
TTCCATAGTAAATTTGGAATCAGAACTCCAAATGCAACTTCGGGCTCGCTGGAGAACAAC
TAA
GenBank Gene IDZ31357
GeneCard IDNot Available
GenAtlas IDCDO1
HGNC IDHGNC:1795
Chromosome Location5
Locus5q22-q23
References
  1. McCann KP, Akbari MT, Williams AC, Ramsden DB: Human cysteine dioxygenase type I: primary structure derived from base sequencing of cDNA. Biochim Biophys Acta. 1994 Nov 16;1209(1):107-10. 7524679
  2. Tsuboyama-Kasaoka N, Hosokawa Y, Kodama H, Matsumoto A, Oka J, Totani M: Human cysteine dioxygenase gene: structural organization, tissue-specific expression and downregulation by phorbol 12-myristate 13-acetate. Biosci Biotechnol Biochem. 1999 Jun;63(6):1017-24. 10427686
  3. Ramsden DB, Kapadi A, Fitch NJ, Farmer MJ, Bennett P, Williams AC: Human cysteine dioxygenase type I (CDO-I; EC 1.13.11.20): 5' flanking region and intron-exon structure of the gene. Mol Pathol. 1997 Oct;50(5):269-71. 9497919
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