Receptor-type tyrosine-protein phosphatase O

NameReceptor-type tyrosine-protein phosphatase O
Synonyms
  • 3.1.3.48
  • GLEPP1
  • Glomerular epithelial protein 1
  • Protein tyrosine phosphatase U2
  • PTP-U2
  • PTPase U2
  • PTPU2
  • R-PTP-O
Gene NamePTPRO
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009013|Receptor-type tyrosine-protein phosphatase O
MGHLPTGIHGARRLLPLLWLFVLFKNATAFHVTVQDDNNIVVSLEASDVISPASVYVVKI
TGESKNYFFEFEEFNSTLPPPVIFKASYHGLYYIITLVVVNGNVVTKPSRSITVLTKPLP
VTSVSIYDYKPSPETGVLFEIHYPEKYNVFTRVNISYWEGKDFRTMLYKDFFKGKTVFNH
WLPGMCYSNITFQLVSEATFNKSTLVEYSGVSHEPKQHRTAPYPPQNISVRIVNLNKNNW
EEQSGNFPEESFMRSQDTIGKEKLFHFTEETPEIPSGNISSGWPDFNSSDYETTSQPYWW
DSASAAPESEDEFVSVLPMEYENNSTLSETEKSTSGSFSFFPVQMILTWLPPKPPTAFDG
FHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTFSSSGSCETRKSQSAKSLSF
YISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQR
LEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYP
LGPTAVVLSWTRPYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLP
AWYYNFRVTMVTWGDPELSCCDSSTISFITAPVAPEITSVEYFNSLLYISWTYGDDTTDL
SHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRLVK
LEPAPPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTI
SSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLIGLLLVT
LIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWRRSIFAFLTLLPSCLWTDYLLAFY
INPWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLP
LNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRND
FWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRH
FRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGV
GRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK
QQFCISDVIYENVSKS
Number of residues1216
Molecular Weight138342.845
Theoretical pINot Available
GO Classification
Functions
  • protein homodimerization activity
  • phosphatase activity
  • transmembrane receptor protein tyrosine phosphatase activity
  • Wnt-protein binding
  • protein tyrosine phosphatase activity
Processes
  • cell morphogenesis
  • negative regulation of glomerular filtration
  • axon guidance
  • peptidyl-tyrosine dephosphorylation
  • negative regulation of cell-substrate adhesion
  • glomerulus development
  • negative regulation of neuron projection development
  • glomerular visceral epithelial cell differentiation
  • protein dephosphorylation
  • lamellipodium assembly
  • negative regulation of retinal ganglion cell axon guidance
  • regulation of glomerular filtration
  • slit diaphragm assembly
  • monocyte chemotaxis
  • negative regulation of canonical Wnt signaling pathway
Components
  • integral component of membrane
  • extracellular exosome
  • lamellipodium
  • integral component of plasma membrane
  • neuron projection
  • apical plasma membrane
  • growth cone
  • lateral plasma membrane
  • dendritic spine
  • axon
  • plasma membrane
General FunctionWnt-protein binding
Specific FunctionPossesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity).
Pfam Domain Function
Transmembrane Regions823-843
GenBank Protein IDNot Available
UniProtKB IDQ16827
UniProtKB Entry NamePTPRO_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0013563|Receptor-type tyrosine-protein phosphatase O (PTPRO)
ATGGGGCACCTGCCCACGGGGATACACGGCGCCCGCCGCCTCCTGCCTCTGCTCTGGCTC
TTTGTGCTGTTCAAGAATGCTACAGCTTTCCATGTAACTGTCCAAGATGATAATAACATC
GTTGTCTCATTAGAAGCTTCAGACGTCATCAGTCCAGCATCTGTGTATGTTGTGAAGATA
ACTGGTGAATCCAAAAATTATTTCTTCGAATTTGAGGAATTCAACAGCACTTTGCCTCCT
CCTGTTATTTTCAAGGCCAGTTATCATGGCCTTTATTATATAATCACTCTGGTAGTGGTA
AATGGAAATGTGGTGACCAAGCCATCCAGATCAATCACTGTGTTAACAAAACCTCTACCT
GTAACCAGTGTTTCCATATATGACTATAAACCTTCTCCTGAAACAGGAGTCCTGTTTGAA
ATACATTATCCAGAAAAATATAACGTTTTCACAAGAGTGAACATTAGCTACTGGGAAGGT
AAAGACTTCCGGACAATGCTATATAAAGATTTCTTTAAGGGAAAAACAGTATTTAATCAC
TGGCTGCCAGGAATGTGTTATAGTAATATCACCTTTCAGCTGGTATCTGAGGCAACTTTT
AATAAAAGTACCCTTGTTGAGTACAGTGGTGTCAGTCACGAACCCAAACAGCACAGAACT
GCCCCTTATCCACCTCAAAATATTTCCGTTCGTATCGTAAACTTGAACAAAAACAACTGG
GAAGAACAGAGTGGCAATTTCCCAGAAGAATCCTTCATGAGATCACAAGATACAATAGGA
AAAGAAAAACTCTTCCATTTTACAGAAGAAACCCCTGAAATTCCCTCGGGCAACATTTCT
TCCGGTTGGCCTGATTTTAATAGCAGTGACTATGAAACTACGTCTCAGCCATATTGGTGG
GACAGTGCATCTGCAGCTCCTGAAAGTGAAGATGAATTTGTCAGCGTACTTCCCATGGAA
TACGAAAATAACAGTACACTCAGTGAGACAGAGAAGTCAACATCAGGCTCTTTCTCCTTT
TTCCCTGTGCAAATGATATTGACCTGGTTACCACCCAAACCACCCACTGCTTTTGATGGG
TTCCATATCCATATTGAACGAGAAGAGAACTTTACTGAATATTTGATGGTGGATGAAGAA
GCACATGAATTTGTTGCAGAACTGAAGGAACCTGGGAAATATAAGTTATCTGTGACAACC
TTTAGTTCCTCAGGATCTTGTGAAACTCGAAAAAGTCAGTCAGCAAAATCACTCAGCTTT
TATATCAGTCCTTCAGGAGAGTGGATTGAAGAACTGACCGAGAAGCCGCAGCACGTGAGT
GTCCACGTTTTAAGCTCAACCACTGCCTTGATGTCCTGGACATCTTCCCAAGAGAACTAC
AACAGCACCATTGTGTCTGTGGTGTCGCTGACCTGCCAGAAACAAAAGGAGAGCCAGAGG
CTTGAAAAGCAGTACTGCACTCAGGTGAACTCAAGCAAACCTATTATTGAAAATCTGGTT
CCTGGTGCCCAGTACCAGGTTGTAATATACCTAAGGAAAGGCCCTTTGATTGGACCACCT
TCAGATCCTGTGACATTTGCTATTGTTCCCACAGGAATAAAGGATTTAATGCTCTATCCT
TTGGGTCCTACGGCCGTGGTTCTGAGCTGGACCAGACCTTATTTAGGCGTGTTCAGAAAA
TACGTGGTTGAAATGTTTTATTTCAACCCTGCTACAATGACATCAGAGTGGACCACCTAC
TATGAAATAGCAGCAACTGTTTCCTTAACTGCATCCGTGAGAATAGCTAATCTGCTGCCA
GCATGGTACTACAACTTCCGGGTTACCATGGTGACGTGGGGAGATCCAGAATTGAGCTGC
TGTGACAGCTCTACCATCAGCTTCATAACAGCCCCAGTGGCTCCGGAAATCACTTCTGTG
GAATATTTCAACAGTCTGTTATATATCAGTTGGACATATGGGGATGATACAACGGACTTG
TCCCATTCTAGAATGCTTCACTGGATGGTGGTTGCAGAAGGAAAAAAGAAAATTAAAAAG
AGTGTAACACGCAATGTCATGACTGCAATTCTCAGCTTGCCTCCAGGCGACATCTATAAC
CTCTCAGTAACTGCTTGTACTGAAAGAGGAAGTAATACCTCCATGCTCCGCCTTGTCAAG
CTAGAACCAGCTCCACCCAAATCACTCTTCGCAGTGAACAAAACCCAGACTTCAGTGACT
TTGCTGTGGGTGGAAGAGGGAGTAGCTGATTTCTTTGAAGTTTTCTGTCAACAAGTTGGC
TCCAGTCAGAAAACCAAACTTCAGGAACCAGTTGCTGTTTCTTCCCATGTCGTGACCATC
TCCAGCCTTCTTCCTGCCACTGCCTACAATTGTAGTGTCACCAGCTTTAGCCATGACAGC
CCCAGTGTCCCTACGTTCATAGCCGTCTCAACAATGGTTACAGAGATGAATCCCAATGTG
GTAGTGATCTCCGTGCTGGCCATCCTTAGCACACTTTTAATTGGACTGTTGCTTGTTACC
CTCATTATTCTTAGGAAAAAGCATCTGCAGATGGCTAGGGAGTGTGGAGCTGGTACATTT
GTCAATTTTGCATCCTTAGAGAGGGATGGAAAGCTTCCATACAACTGGAGTAAAAATGGT
TTAAAGAAGAGGAAACTGACAAACCCGGTTCAACTGGATGACTTTGATGCCTATATTAAG
GATATGGCCAAAGACTCTGACTATAAATTTTCTCTTCAGTTTGAGGAGTTGAAATTGATT
GGACTGGATATCCCACACTTTGCTGCAGATCTTCCACTGAATCGATGTAAAAACCGTTAC
ACAAACATCCTACCATATGACTTCAGCCGTGTGAGATTAGTCTCCATGAATGAAGAGGAA
GGTGCAGACTACATCAATGCCAACTATATTCCTGGATACAACTCACCCCAGGAGTATATT
GCCACCCAGGGGCCACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAA
AAGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAGGAGGGTGAAATGTGAC
CATTACTGGCCATTCACGGAAGAACCTATAGCCTATGGAGACATCACTGTGGAGATGATT
TCAGAGGAAGAGCAGGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAG
ATGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCATGGTGTGCCCACAGCA
AATGCTGCAGAAAGTATCCTGCAGTTTGTACACATGGTCCGACAGCAAGCTACCAAGAGC
AAAGGTCCCATGATCATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCC
CTGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGACATCTTAGGGCTGGTG
TCAGAAATGAGGTCATACCGGATGTCTATGGTACAGACAGAGGAGCAGTACATTTTTATC
CATCAGTGTGTGCAACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTC
ATATACGAGAATGTTAGCAAGTCCTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9678
Chromosome Location12
LocusNot Available
References
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