NamePotassium voltage-gated channel subfamily A member 10
Synonyms
  • Voltage-gated potassium channel subunit Kv1.8
Gene NameKCNA10
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013280|Potassium voltage-gated channel subfamily A member 10
MDVCGWKEMEVALVNFDNSDEIQEEPGYATDFDSTSPKGRPGGSSFSNGKILISESTNHE
TAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGLRFETQLRTLSQFPETLLGDREKRMQ
FFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFYELGSEAMDQFR
EDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPE
FREDRELKVVRDPNLNMSKTVLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFF
RNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKG
LQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMT
TVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQNIPGEI
ERILNSVGSRMGSTDSLNKTNGGCSTEKSRK
Number of residues511
Molecular Weight57784.47
Theoretical pINot Available
GO Classification
Functions
  • intracellular cyclic nucleotide activated cation channel activity
  • delayed rectifier potassium channel activity
Processes
  • potassium ion transport
  • synaptic transmission
  • potassium ion transmembrane transport
  • protein homooligomerization
Components
  • plasma membrane
  • voltage-gated potassium channel complex
  • integral component of membrane
General FunctionIntracellular cyclic nucleotide activated cation channel activity
Specific FunctionMediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP.
Pfam Domain Function
Transmembrane Regions218-238 271-292 303-323 339-358 375-395 436-456
GenBank Protein IDNot Available
UniProtKB IDQ16322
UniProtKB Entry NameKCA10_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0013281|Potassium voltage-gated channel subfamily A member 10 (KCNA10)
ATGGATGTGTGTGGCTGGAAAGAAATGGAGGTTGCGCTGGTCAATTTTGATAATTCAGAT
GAAATCCAAGAAGAGCCAGGCTATGCCACAGACTTCGACTCAACCAGCCCAAAAGGCCGG
CCTGGGGGCAGCTCCTTCTCCAACGGGAAGATCCTCATCAGCGAAAGCACCAACCATGAG
ACGGCCTTCTCCAAGCTTCCGGGAGACTATGCTGACCCCCCAGGGCCTGAGCCAGTGGTC
CTAAATGAAGGAAACCAGCGGGTGATCATCAACATTGCTGGGCTGAGATTTGAGACCCAG
CTCAGAACCCTTAGTCAGTTCCCAGAGACTCTCCTGGGAGACCGGGAAAAAAGGATGCAG
TTCTTTGACTCCATGAGAAATGAGTATTTCTTTGATCGGAACCGGCCCAGTTTTGATGGA
ATCCTATATTATTACCAATCTGGTGGGAAAATTCGGCGCCCAGCCAATGTTCCCATTGAT
ATCTTTGCTGATGAAATCTCCTTCTATGAGCTGGGTAGTGAGGCCATGGACCAGTTCCGG
GAGGATGAAGGCTTCATCAAAGACCCTGAAACACTGCTACCCACCAATGACATCCACCGT
CAGTTCTGGCTCCTCTTTGAGTACCCTGAAAGTTCCAGCGCTGCCCGTGCTGTGGCCGTG
GTCTCGGTGTTGGTTGTGGTCATCTCCATCACCATCTTCTGCCTGGAGACACTGCCAGAG
TTCCGGGAGGATAGGGAGCTAAAGGTGGTCAGAGACCCCAATCTCAACATGAGCAAGACA
GTCCTCTCCCAGACCATGTTCACCGACCCTTTCTTCATGGTGGAGTCTACCTGCATCGTG
TGGTTCACCTTCGAGCTGGTGCTCCGGTTCGTGGTCTGCCCCAGCAAGACTGACTTCTTC
AGGAACATCATGAACATCATTGACATCATCTCCATTATCCCCTACTTTGCAACTCTCATC
ACAGAGCTAGTCCAGGAGACAGAGCCGAGTGCCCAACAGAACATGTCCCTGGCCATCCTG
AGGATCATCCGCCTGGTGAGGGTCTTCCGCATCTTCAAGCTCTCGCGCCACTCCAAGGGG
CTGCAGATCCTCGGGCAAACACTGAAGGCGTCCATGCGGGAGTTGGGGTTGCTCATCTTC
TTTCTCTTCATTGGAGTCATCCTCTTCTCCAGTGCAGTCTACTTTGCTGAGGTGGATGAG
CCAGAGTCCCATTTCTCTAGCATTCCTGATGGCTTCTGGTGGGCAGTGGTCACCATGACA
ACTGTAGGCTATGGGGACATGTGCCCGACCACCCCAGGGGGGAAGATTGTGGGCACTCTG
TGTGCCATTGCAGGGGTCCTCACCATTGCCCTCCCTGTGCCTGTCATTGTCTCCAACTTC
AATTACTTCTACCACCGGGAGACTGAGAATGAAGAAAAGCAGAACATCCCAGGAGAAATT
GAAAGAATCCTCAACAGTGTAGGCTCAAGAATGGGCAGCACAGACTCTCTTAATAAGACC
AATGGTGGCTGTTCCACAGAGAAGTCTAGGAAATGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:6219
Chromosome Location1
LocusNot Available
References
  1. Orias M, Bray-Ward P, Curran ME, Keating MT, Desir GV: Genomic localization of the human gene for KCNA10, a cGMP-activated K channel. Genomics. 1997 May 15;42(1):33-7. 9177773
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