Mothers against decapentaplegic homolog 1

NameMothers against decapentaplegic homolog 1
Synonyms
  • BSP-1
  • BSP1
  • hSMAD1
  • JV4-1
  • MAD homolog 1
  • Mad-related protein 1
  • MADH1
  • MADR1
  • SMAD 1
  • SMAD family member 1
  • Smad1
  • Transforming growth factor-beta-signaling protein 1
Gene NameSMAD1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009303|Mothers against decapentaplegic homolog 1
MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQ
PSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEV
CINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPN
SHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQ
PMDTNMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT
DPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC
NYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW
GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
Number of residues465
Molecular Weight52259.72
Theoretical pINot Available
GO Classification
Functions
  • transcription factor activity, sequence-specific DNA binding
  • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
  • identical protein binding
  • protein kinase binding
  • I-SMAD binding
  • receptor signaling protein activity
  • RNA polymerase II core promoter sequence-specific DNA binding
  • metal ion binding
  • co-SMAD binding
Processes
  • transcription from RNA polymerase II promoter
  • cartilage development
  • primary miRNA processing
  • positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
  • hindbrain development
  • cardiac muscle cell proliferation
  • gamete generation
  • SMAD protein complex assembly
  • MAPK cascade
  • mesodermal cell fate commitment
  • embryonic pattern specification
  • negative regulation of cell proliferation
  • osteoblast fate commitment
  • midbrain development
  • positive regulation of transcription from RNA polymerase II promoter
  • positive regulation of cartilage development
  • ureteric bud development
  • bone development
  • signal transduction
  • homeostatic process
  • transforming growth factor beta receptor signaling pathway
  • positive regulation of gene expression
  • SMAD protein signal transduction
  • BMP signaling pathway
  • inflammatory response
  • cellular response to BMP stimulus
  • positive regulation of osteoblast differentiation
Components
  • integral component of membrane
  • cytosol
  • nucleoplasm
  • intracellular
  • cytoplasm
  • transcription factor complex
  • nuclear inner membrane
  • protein complex
  • nucleus
  • SMAD protein complex
General FunctionTransforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
Specific FunctionTranscriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ15797
UniProtKB Entry NameSMAD1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0013729|Mothers against decapentaplegic homolog 1 (SMAD1)
ATGAATGTGACAAGTTTATTTTCCTTTACAAGTCCAGCTGTGAAGAGACTTCTTGGGTGG
AAACAGGGCGATGAAGAAGAAAAATGGGCAGAGAAAGCTGTTGATGCTTTGGTGAAAAAA
CTGAAGAAAAAGAAAGGTGCCATGGAGGAACTGGAAAAGGCCTTGAGCTGCCCAGGGCAA
CCGAGTAACTGTGTCACCATTCCCCGCTCTCTGGATGGCAGGCTGCAAGTCTCCCACCGG
AAGGGACTGCCTCATGTCATTTACTGCCGTGTGTGGCGCTGGCCCGATCTTCAGAGCCAC
CATGAACTAAAACCACTGGAATGCTGTGAGTTTCCTTTTGGTTCCAAGCAGAAGGAGGTC
TGCATCAATCCCTACCACTATAAGAGAGTAGAAAGCCCTGTACTTCCTCCTGTGCTGGTT
CCAAGACACAGCGAATATAATCCTCAGCACAGCCTCTTAGCTCAGTTCCGTAACTTAGGA
CAAAATGAGCCTCACATGCCACTCAACGCCACTTTTCCAGATTCTTTCCAGCAACCCAAC
AGCCACCCGTTTCCTCACTCTCCCAATAGCAGTTACCCAAACTCTCCTGGGAGCAGCAGC
AGCACCTACCCTCACTCTCCCACCAGCTCAGACCCAGGAAGCCCTTTCCAGATGCCAGCT
GATACGCCCCCACCTGCTTACCTGCCTCCTGAAGACCCCATGACCCAGGATGGCTCTCAG
CCGATGGACACAAACATGATGGCGCCTCCCCTGCCCTCAGAAATCAACAGAGGAGATGTT
CAGGCGGTTGCTTATGAGGAACCAAAACACTGGTGCTCTATTGTCTACTATGAGCTCAAC
AATCGTGTGGGTGAAGCGTTCCATGCCTCCTCCACAAGTGTGTTGGTGGATGGTTTCACT
GATCCTTCCAACAATAAGAACCGTTTCTGCCTTGGGCTGCTCTCCAATGTTAACCGGAAT
TCCACTATTGAAAACACCAGGCGGCATATTGGAAAAGGAGTTCATCTTTATTATGTTGGA
GGGGAGGTGTATGCCGAATGCCTTAGTGACAGTAGCATCTTTGTGCAAAGTCGGAACTGC
AACTACCATCATGGATTTCATCCTACTACTGTTTGCAAGATCCCTAGTGGGTGTAGTCTG
AAAATTTTTAACAACCAAGAATTTGCTCAGTTATTGGCACAGTCTGTGAACCATGGATTT
GAGACAGTCTATGAGCTTACAAAAATGTGTACTATACGTATGAGCTTTGTGAAGGGCTGG
GGAGCAGAATACCACCGCCAGGATGTTACTAGCACCCCCTGCTGGATTGAGATACATCTG
CACGGCCCCCTCCAGTGGCTGGATAAAGTTCTTACTCAAATGGGTTCACCTCATAATCCT
ATTTCATCTGTATCTTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:6767
Chromosome Location4
LocusNot Available
References
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