Rho-related GTP-binding protein RhoH
| Name | Rho-related GTP-binding protein RhoH |
|---|---|
| Synonyms |
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| Gene Name | RHOH |
| Organism | Human |
| Amino acid sequence | >lcl|BSEQ0019720|Rho-related GTP-binding protein RhoH MLSSIKCVLVGDSAVGKTSLLVRFTSETFPEAYKPTVYENTGVDVFMDGIQISLGLWDTA GNDAFRSIRPLSYQQADVVLMCYSVANHNSFLNLKNKWIGEIRSNLPCTPVLVVATQTDQ REMGPHRASCVNAMEGKKLAQDVRAKGYLECSALSNRGVQQVFECAVRTAVNQARRRNRR RLFSINECKIF |
| Number of residues | 191 |
| Molecular Weight | 21330.35 |
| Theoretical pI | Not Available |
| GO Classification | Functions
Processes
Components
|
| General Function | Rho gtpase binding |
| Specific Function | Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (By similarity). Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils. |
| Pfam Domain Function |
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| Transmembrane Regions | Not Available |
| GenBank Protein ID | Not Available |
| UniProtKB ID | Q15669 |
| UniProtKB Entry Name | RHOH_HUMAN |
| Cellular Location | Cytoplasm |
| Gene sequence | >lcl|BSEQ0019721|Rho-related GTP-binding protein RhoH (RHOH) ATGCTGAGTTCCATCAAGTGCGTGTTGGTGGGCGACTCTGCTGTGGGGAAAACCTCTCTG TTGGTGCGCTTCACCTCCGAGACCTTCCCGGAGGCCTACAAGCCCACAGTGTACGAGAAC ACAGGGGTGGACGTCTTCATGGATGGCATCCAGATCAGCCTGGGCCTCTGGGACACAGCC GGCAATGACGCCTTCAGAAGCATCCGGCCCCTGTCCTACCAGCAGGCAGACGTGGTGCTG ATGTGCTACTCTGTGGCCAACCATAACTCATTCCTGAACTTGAAGAACAAGTGGATTGGT GAAATTAGGAGCAACTTGCCCTGTACCCCTGTGCTGGTGGTGGCCACCCAGACTGACCAG CGGGAGATGGGGCCCCACAGGGCCTCCTGCGTCAATGCCATGGAAGGGAAGAAACTGGCC CAGGATGTCAGAGCCAAGGGCTACCTGGAGTGCTCAGCCCTTAGCAATCGGGGAGTACAG CAGGTGTTTGAGTGCGCCGTCCGAACTGCCGTCAACCAGGCCAGGAGACGAAACAGAAGG AGGCTCTTCTCCATCAATGAGTGCAAGATCTTCTAA |
| GenBank Gene ID | Not Available |
| GeneCard ID | Not Available |
| GenAtlas ID | Not Available |
| HGNC ID | HGNC:686 |
| Chromosome Location | 4 |
| Locus | Not Available |
| References |
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